Journal article
The Cleaved Peptide of PAR1 Results in a Redistribution of the Platelet Surface GPIb-IX-V Complex to the Surface-Connected Canalicular System
Abstract
The only known function of the 41 amino acid cleaved peptide (TR1-41) of the seven transmembrane domain thrombin receptor (PARI) is to activate platelets (as determined by aggregation, surface P-selectin, and fibrinogen binding to activated GPIIb-IIIa). We now demonstrate that TR1-41 results in a concentration-dependent decrease in the platelet surface expression of each component of the GPIb-IX-V complex, as determined by flow cytometry with a …
Authors
Furman MI; Nurden P; Berndt MC; Nurden AT; Benoit SE; Barnard MR; Ofosu FA; Michelson AD
Journal
Thrombosis and Haemostasis, Vol. 84, No. 05, pp. 897–903
Publisher
Thieme
Publication Date
2000
DOI
10.1055/s-0037-1614134
ISSN
0340-6245