Journal article
Unfractionated heparin inhibits thrombin-catalysed amplification reactions of coagulation more efficiently than those catalysed by factor Xa
Abstract
We have proposed previously that the steps in coagulation most sensitive to inhibition by heparin are the thrombin-dependent amplification reactions, and that prothrombinase is formed in heparinized plasma only after Factor Xa activates Factor VIII and Factor V. These propositions were based on the demonstration that both heparin and Phe-Pro-Arg-CH2Cl completely inhibited 125I-prothrombin activation for up to 60 s when contact-activated plasma …
Authors
Ofosu FA; Hirsh J; Esmon CT; Modi GJ; Smith LM; Anvari N; Buchanan MR; Fenton JW; Blajchman MA
Journal
Biochemical Journal, Vol. 257, No. 1, pp. 143–150
Publisher
Portland Press
Publication Date
January 1, 1989
DOI
10.1042/bj2570143
ISSN
0264-6021