Journal article
Antithrombotic Properties of Heparin in a Neonatal Piglet Model of Thrombin-Induced Thrombosis
Abstract
The relative deficiency of antithrombin III (AT III) in neonatal plasma results in lower recovery of heparin in some assay systems. It is uncertain whether low AT III levels also limit the antithrombotic effects of heparin in this age group. We therefore compared the antithrombotic properties of heparin in mature pigs and newborn piglets, whose coagulation and inhibitor system closely resembles that of the human neonate. Animals were pretreated …
Authors
Schmidt B; Buchanan MR; Ofosu F; Brooker L; Hirsh J; Andrew M
Journal
Thrombosis and Haemostasis, Vol. 60, No. 02, pp. 289–292
Publisher
Thieme
Publication Date
1988
DOI
10.1055/s-0038-1647046
ISSN
0340-6245