Coordinate Activation of Human Platelet Protease-activated Receptor-1 and -4 in Response to Subnanomolar α-Thrombin Academic Article uri icon

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abstract

  • We previously demonstrated that human platelets activated with SFLLRN release PAR-1 activation peptide, PAR-1-(1-41), even in the presence of hirudin. This observation suggests that during their activation, platelets generate a protease that activates PAR-1. In this study, PAR-1 and -4 activation peptides were detected 10 s after

authors

  • Ofosu, Frederick A
  • Dewar, Lori
  • Craven, Sharon J
  • Song, Yingqi
  • Cedrone, Aisha
  • Freedman, John
  • Fenton, John W

publication date

  • October 3, 2008