Journal article
Covalent antithrombin-heparin effect on thrombin-thrombomodulin and activated protein C reaction with factor V/Va
Abstract
Thrombomodulin (TM), which variably contains a chondroitin sulfate (+/-CS), forms an anticoagulant complex with thrombin (IIa). IIa-TM(+/-CS) converts protein C (PC) into activated PC (APC), which then inactivates activated factors V (FVa) and VIII (FVIIIa). This reduces prothrombinase and tenase complexes that generate IIa. Heparin (H) increases the rate of IIa-TM inhibition by antithrombin (AT) and enhances FV cleavage by APC. Our novel …
Authors
Van Walderveen MC; Berry LR; Atkinson HM; Chan AKC
Journal
Thrombosis and Haemostasis, Vol. 103, No. 05, pp. 910–919
Publisher
Thieme
Publication Date
2010
DOI
10.1160/th09-07-0473
ISSN
0340-6245