Journal article
INVESTIGATION OF THE PATHOLOGICAL EFFECTS OF HISTONES, DNA, AND NUCLEOSOMES IN A MURINE MODEL OF SEPSIS
Abstract
ABSTRACT: Background: In sepsis, neutrophil extracellular traps (NETs) are an important interface between innate immunity and coagulation. The major structural component of neutrophil extracellular traps is nucleosomes (DNA-histone complexes). In vitro, DNA and histones exert procoagulant/cytotoxic effects whereas nucleosomes are not harmful. However, whether DNA, histones, and/or nucleosomes exert harmful effects in vivo remain unclear. …
Authors
Medeiros SK; Sharma N; Dwivedi D; Liaw PC
Journal
Shock, Vol. 60, No. 2, pp. 291–297
Publisher
Wolters Kluwer
Publication Date
8 2023
DOI
10.1097/shk.0000000000002165
ISSN
1073-2322