Journal article
Effects of Dermatan Sulfate and Heparin on Inhibition of Thrombus Growth in Vivo
Abstract
The effects of dermatan sulfate and heparin on inhibition of fibrin accretion onto existing thrombi as related to their ex vivo anticoagulant activity and abilities to inhibit increased prothrombin clearance induced by thrombi were investigated. Our results indicate that for equivalent anti-thrombin activities, dermatan sulfate is a more effective inhibitor of fibrin accretion onto existing thrombi than is heparin. These observations raise the …
Authors
VAN RYN‐McKENNA J; OFOSU FA; GRAY E; HIRSH J; BUCHANAN MR
Journal
Annals of the New York Academy of Sciences, Vol. 556, No. 1, pp. 304–312
Publisher
Wiley
Publication Date
6 1989
DOI
10.1111/j.1749-6632.1989.tb22512.x
ISSN
0077-8923