Protease activated receptors 1 and 4 govern the responses of human platelets to thrombin Academic Article uri icon

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abstract

  • Studies carried out in the past 12 years have established that activation of protease-activated receptor (PAR)-1 and PAR-4 by thrombin essentially drives human platelet activation. Thrombin is the most potent physiologic agonist of platelets. PAR-1 and PAR-4 are found on human platelets and are half of the family of the four known 7-transmembrane receptors that are activated by a single proteolytic cleavage within the amino terminal extracellular domain of these receptors. This review will consider the direct and indirect evidence that apparently support the idea that PAR-1 and PAR-4 activation by thrombin drives platelet activation

publication date

  • June 2003