Journal article
The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal‐based and cell‐based models
Abstract
BACKGROUND: Thrombosis is a common complication in cancer patients receiving chemotherapy regimens that include cyclophosphamide. However, the mechanisms by which these agents increase this risk are largely uncharacterized.
OBJECTIVES: To examine the effects of cyclophosphamide and its metabolite acrolein on procoagulant and anticoagulant pathways in both cell-based and animal-based models.
Authors
SWYSTUN LL; MUKHERJEE S; LEVINE M; LIAW PC
Journal
Journal of Thrombosis and Haemostasis, Vol. 9, No. 4, pp. 767–775
Publisher
Elsevier
Publication Date
April 2011
DOI
10.1111/j.1538-7836.2011.04232.x
ISSN
1538-7933