A single dose of aprotinin prevents platelet hyporeactivity after coronary artery bypass graft surgery.

INTRODUCTION: Bleeding after coronary artery bypass graft (CABG) surgery is associated with a significant increase in mortality. Even though aprotinin significantly reduces bleeding in patients undergoing cardiac surgery, its use has been recently substantially limited because of serious cardiovascular complications. The exact mechanism of its action, particularly its effect on platelet function, remains unclear. OBJECTIVES: The aim of the …