Journal article
Use of Hirulog in the prevention of venous thrombosis after major hip or knee surgery.
Abstract
BACKGROUND: The study objective was to determine whether Hirulog, a direct thrombin inhibitor, has potential efficacy and safety in the prevention of deep vein thrombosis (DVT) in orthopedic patients. A phase 2 open-label, dose-escalating design was used to study 222 unselected patients undergoing major hip or knee surgery in tertiary-care, university-affiliated hospitals.
METHODS AND RESULTS: Subcutaneous Hirulog was initiated postoperatively. …
Authors
Ginsberg JS; Nurmohamed MT; Gent M; MacKinnon B; Sicurella J; Brill-Edwards P; Levine MN; Panju AA; Powers P; Stevens P
Journal
Circulation, Vol. 90, No. 5, pp. 2385–2389
Publisher
Wolters Kluwer
Publication Date
November 1994
DOI
10.1161/01.cir.90.5.2385
ISSN
0009-7322