Journal article
A safety review of topical bovine thrombin-induced generation of antibodies to bovine proteins
Abstract
BACKGROUND: Topical bovine thrombin has been used to accelerate attainment of hemostasis in the surgical setting for >60 years, and its immunogenicity has been widely reported. Although the development of antibodies is inherent in the introduction of any non-self-therapeutic protein such as bovine-sourced thrombin, there are questions about the relationship between the presence of antibodies to constituents of the therapeutic protein …
Authors
Ofosu FA; Crean S; Reynolds MW
Journal
Clinical Therapeutics, Vol. 31, No. 4, pp. 679–691
Publisher
Elsevier
Publication Date
April 2009
DOI
10.1016/j.clinthera.2009.04.021
ISSN
0149-2918