Clinical Trials as Topic Concept

subject area of

•   Journal Articles
• "Therapeutic range" for oral anticoagulant therapy.  Journal Articles
• 236th ENMC International Workshop Bone protective therapy in Duchenne muscular dystrophy: Determining the feasibility and standards of clinical trials Hoofddorp, The Netherlands, 1–3 June 2018  Journal Articles
• 24-hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer during oral administration of cimetidine and atropine.  Journal Articles
• Helicobacter pyloriEradication: A Critical Appraisal and Current Concerns  Journal Articles
• A 35-year journey to evidence-based medicine: a personal story  Journal Articles
• A Bayesian adaptive design for clinical trials of rare efficacy outcomes with multiple definitions  Journal Articles
• A Comparative Randomized Trial of Low-Dose Versus High-Dose Streptokinase in Deep Vein Thrombosis of the Thigh  Journal Articles
• A Comparison of Two Bias‐Corrected Covariance Estimators for Generalized Estimating Equations  Journal Articles
• A Comparison of Zomepirac and Codeine as Analgesic Premedicants in Short-stay Surgery  Journal Articles
• A Consensus Development Approach to Define National Research Priorities in Bone Metastases: Proceedings from NCIC CTG Workshop  Journal Articles
• A Controlled Trial of Ambroxol in Chronic Bronchitis  Journal Articles
• A Core Outcome Set for Efficacy of Acute Treatment of Hereditary Angioedema  Journal Articles
• A Double‐Blind Crossover Study of Cinromide Versus Placebo in Epileptic Outpatients with Partial Seizures  Journal Articles
• A Large Trial Is Vital to Prove Perioperative β-blockade Effectiveness and Safety before Widespread Use  Journal Articles
• A Meta-analysis of the Studies of Dihydroergotamine plus Heparin in the Prophylaxis of Deep Vein Thrombosis  Journal Articles
• A Phase II Study of PF-03446962 in Patients with Advanced Malignant Pleural Mesothelioma. CCTG Trial IND.207  Journal Articles
• A Practical Guide to Research: Design, Execution, and Publication  Journal Articles
• A Randomized Clinical Trial of the Leboyer Approach to Childbirth  Journal Articles
• A Randomized Controlled Trial of a Low-Molecular-Weight Heparin (Enoxaparin) to Prevent Deep-Vein Thrombosis in Patients Undergoing Elective Hip Surgery  Journal Articles
• A Systematic Review and Canadian Consensus Recommendations on the Use of Biomarkers in the Treatment of Non-small Cell Lung Cancer  Journal Articles
• A Systematic Review and Meta-Analysis Evaluating the Efficacy of a Gluten-Free Diet and a Low FODMAPS Diet in Treating Symptoms of Irritable Bowel Syndrome  Journal Articles
• A Systematic Review and Meta‐Analyses of Nonsucrose Sweet Solutions for Pain Relief in Neonates  Journal Articles
• A call for consensus in defining efficacy in clinical trials for opioid addiction: combined results from a systematic review and qualitative study in patients receiving pharmacological assisted therapy for opioid use disorder  Journal Articles
• A clinician's guide for conducting randomized trials in individual patients.  Journal Articles
• A closer look at the distribution of number needed to treat (NNT): a Bayesian approach  Journal Articles
• A comparative study of continuous and intermittent epidural analgesia for labour and delivery  Journal Articles
• A comparison of Golytely and standard preparation for barium enema  Journal Articles
• A comparison of Likert and visual analogue scales for measuring change in function  Journal Articles
• A comparison of community and occupationally provided antihypertensive care.  Journal Articles
• A controlled trial of digoxin in congestive heart failure  Journal Articles
• A cost-effectiveness analysis of alternative approaches for long-term treatment of proximal venous thrombosis  Journal Articles
• A critical review of the evidence supporting a relationship between impaired fibrinolytic activity and venous thromboembolism  Journal Articles
• A double blind placebo controlled crossover randomized trial of diltiazem in Raynaud's phenomenon.  Journal Articles
• A double-blind comparison of carbonated lidocaine and lidocaine hydrochloride in epidural anaesthesia  Journal Articles
• A double-blind randomized study comparing different dose regimens of H2-receptor antagonists on 24-hour gastric secretion in normal subjects and duodenal ulcer patients.  Journal Articles
• A double‐blind comparison of ketotifen and disodium cromoglycate in atopic adult asthmatics  Journal Articles
• A framework for clinical evaluation of diagnostic technologies.  Journal Articles
• A large number of COVID-19 interventional clinical trials were registered soon after the pandemic onset: a descriptive analysis  Journal Articles
• A longitudinal drug study and central amines.  Journal Articles
• A measure of quality of life for clinical trials in chronic lung disease.  Journal Articles
• A meta-analysis of the therapeutic role of oil soluble contrast media at hysterosalpingography: a surprising result?  Journal Articles
• A multi-centre clinical evaluation of isoflurane  Journal Articles
• A multicenter comparative trial of tobramycin and ticarcillin vs moxalactam and ticarcillin in febrile neutropenic patients  Journal Articles
• A multicentre prospective randomized trial comparing ceftazidime with cefazolin/tobramycin in the treatment of hospitalized patients with non-pneumococcal pneumonia  Journal Articles
• A new era in idiopathic pulmonary fibrosis: considerations for future clinical trials  Journal Articles
• A new measure of health status for clinical trials in inflammatory bowel disease  Journal Articles
• A new perspective on concepts of asthma severity and control  Journal Articles
• A new respiratory fluoroquinolone, oral gemifloxacin: a safety profile in context  Journal Articles
• A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis Genetic modifier studies  Journal Articles
• A phase II study of bortezomib and gemcitabine in relapsed mantle cell lymphoma from the National Cancer Institute of Canada Clinical Trials Group (IND 172)  Journal Articles
• A placebo‐controlled study to determine the efficacy of oral disopyramide phosphate for the prophylaxis of ventricular dysrhythmias after acute myocardial infarction.  Journal Articles
• A probabilistic cost-effectiveness analysis of enoxaparin versus unfractionated heparin for the prophylaxis of deep-vein thrombosis following major trauma.  Journal Articles
• A qualitative interview study exploring the psychological health impacts of the SPIN-CHAT program among people with systemic sclerosis at the onset of COVID-19: perceptions of trial participants and research team members  Journal Articles
• A qualitative study evaluating causality attribution for serious adverse events during early phase oncology clinical trials  Journal Articles
• A randomized trial of less intense postoperative warfarin or aspirin therapy in the prevention of venous thromboembolism after surgery for fractured hip  Journal Articles
• A randomized trial of maintenance versus no maintenance melphalan and prednisone in responding multiple myeloma patients  Journal Articles
• A real-time dashboard of clinical trials for COVID-19  Journal Articles
• A response to–There’s madness in their methods  Journal Articles
• A review of body mass index and waist circumference as markers of obesity and coronary heart disease risk in persons with chronic spinal cord injury  Journal Articles
• A review of valproate in psychiatric practice  Journal Articles
• A secondary prevention, randomized trial of suloctidil in patients with a recent history of thromboembolic stroke.  Journal Articles
• A short note on probability in clinical medicine  Journal Articles
• A small p-value from an observed data is not evidence of adequate power for future similar-sized studies: A cautionary note  Journal Articles
• A stochastic model for survival of early prostate cancer with adjustments for leadtime, length bias, and over‐detection  Journal Articles
• A systematic overview of the effectiveness of home visiting as a delivery strategy for public health nursing interventions.  Journal Articles
• A systematic review of comparisons between protocols or registrations and full reports in primary biomedical research  Journal Articles
• A systematic review of integrative clinical trials for supportive care in pediatric oncology: a report from the International Society of Pediatric Oncology, T&CM collaborative  Journal Articles
• A systematic review of medication safety and clinical outcomes related to drug interaction software.  Journal Articles
• A systematic review of symptomatic outcomes used in oesophagitis drug therapy trials  Journal Articles
• A tool for assessing the comprehensiveness of outcome reporting within clinical trials in pregnancy  Journal Articles
• A tutorial on sensitivity analyses in clinical trials: the what, why, when and how  Journal Articles
• A “Patient Preference” Model of Recruitment for Research from Primary-Care-Based Memory Clinics: A Promising New Approach  Journal Articles
• ACUTE VINCRISTINE NEUROTOXICITY  Journal Articles
• AHA Conference Report on Cholesterol. Intervention studies.  Journal Articles
• ANTIPLATELET AGENTS: THEIR ROLE IN THE PREVENTION OF SUDDEN DEATH  Journal Articles
• APPLICATION OF THE CONSOLIDATED STANDARDS OF REPORTING TRIALS (CONSORT) IN THE FRACTURE CARE LITERATURE  Journal Articles
• AUSTRALIAN MULTICENTRE TRIAL OF STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION  Journal Articles
• AZATHIOPRINE AND PREDNISONE IN THE TREATMENT OF ADULTS WITH LUPUS NEPHRITIS  Journal Articles
• Absorption and antidysrhythmic activity of oral disopyramide phosphate after acute myocardial infarction.  Journal Articles
• Accelerating Clinical Evaluation of Repurposed Combination Therapies for COVID-19  Journal Articles
• Achieving remission in clinical practice: lessons from clinical trial data.  Journal Articles
• Acid suppression in duodenal ulcer: a meta-analysis to define optimal dosing with antisecretory drugs.  Journal Articles
• Acupuncture as an Evidence-Based Option for Symptom Control in Cancer Patients  Journal Articles
• Acupuncture for Neck Disorders  Journal Articles
• Acute Ischemic Stroke Therapy Overview  Journal Articles
• Acute effects of oral pyridostigmine on memory and cognitive function in SDAT  Journal Articles
• Acute myelogenous leukemia in adolescents and young adults  Journal Articles
• Acute otitis media: clinical course among children who received a short course of high dose antibiotic.  Journal Articles
• Acute response to bronchodilator. An imperfect guide for bronchodilator therapy in chronic airflow limitation  Journal Articles
• Adapting the Lung Cancer Symptom Scale (LCSS) to mesothelioma  Journal Articles
• Addressing dichotomous data for participants excluded from trial analysis: a guide for systematic reviewers  Journal Articles
• Addressing the Unit of Analysis in Medical Care Studies  Journal Articles
• Adjudicating Outcomes: Fundamentals  Journal Articles
• Adjunctive antiarrhythmic drug therapy in patients with implantable cardioverter defibrillators: a systematic review  Journal Articles
• Adjusted Subcutaneous Heparin or Continuous Intravenous Heparin in Patients with Acute Deep Vein Thrombosis  Journal Articles
• Adjusted Subcutaneous Heparin versus Warfarin Sodium in the Long-Term Treatment of Venous Thrombosis  Journal Articles
• Adjuvant chemotherapy: results and perspectives  Journal Articles
• Adjuvant therapy for resected non-small-cell lung cancer: Past, present, and future  Journal Articles
• Advances in Antithrombotic Therapy  Journal Articles
• Advances in Antithrombotic Therapy: Novel Agents  Journal Articles
• Advances in the management of venous thromboembolism  Journal Articles
• Advances in the management of venous thromboembolism.  Journal Articles
• Advancing Academic Cancer Clinical Trials Recruitment in Canada  Journal Articles
• Adverse effects of β-agonists  Journal Articles
• Aerosol Therapy with Sch 1000  Journal Articles
• Airway smooth muscle as a target of asthma therapy: history and new directions  Journal Articles
• Albumin in critical care: SAFE, but worth its salt?  Journal Articles
• Allergen immunotherapy with cat allergen peptides  Journal Articles
• Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs  Journal Articles
• Allogenic leukocyte immunization after five or more miscarriages. Recurrent Miscarriage Immunotherapy Trialists Group  Journal Articles
• American Heart Association/American College of Cardiology Foundation Guide to Warfarin Therapy  Journal Articles
• American college of rheumatology preliminary definition of improvement in rheumatoid arthritis  Journal Articles
• Amiodarone after myocardial infarction: EMIAT and CAMIAT trials.  Journal Articles
• Amoxycillin dual therapy against Helicobacter pylori--the final nail in the coffin?  Journal Articles
• Amyloid-targeted therapeutics in Alzheimer's disease: use of human albumin in plasma exchange as a novel approach for Abeta mobilization.  Journal Articles
• An Evidence-Based Approach to the Adoption of New Technology  Journal Articles
• An Improved Definition of Immune Heparin-Induced Thrombocytopenia in Postoperative Orthopedic Patients  Journal Articles
• An Introduction to Multivariate Statistics  Journal Articles
• An N of 1 Service: Applying the Scientific Method in Clinical Practice  Journal Articles
• An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases  Conferences
• An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations  Journal Articles
• An electrophysiological study of Duchenne dystrophy  Journal Articles
• An evaluation of paroxetine in generalised social anxiety disorder  Journal Articles
• An overview of clinical trials of low molecular weight heparin fractions.  Journal Articles
• An overview of clinical trials of low molecular weight heparin fractions.  Journal Articles
• An overview of platform trials with a checklist for clinical readers  Journal Articles
• An overview of precision oncology basket and umbrella trials for clinicians  Journal Articles
• An overview of randomized trials of rehabilitation with exercise after myocardial infarction.  Journal Articles
• An overview of the GRADE approach and a peek at the future  Journal Articles
• An updated safety profile of moxifloxacin.  Journal Articles
• Analysis of Observational Studies: A Guide to Understanding Statistical Methods  Journal Articles
• Analysis of dose intensity for adjuvant chemotherapy trials in stage II breast cancer.  Journal Articles
• Analysis of dose intensity for chemotherapy in early (stage II) and advanced breast cancer.  Journal Articles
• Analyzing Oncology Clinical Trial Data Using the Q-TWiST Method: Clinical Importance and Sources for Health State Preference Data*  Journal Articles
• Andexanet for Factor Xa Inhibitor-Associated Acute Intracerebral Hemorrhage. Reply.  Journal Articles
• Angiotensin-receptor blockers in prevention of cardiovascular events: are they as effective as angiotensin-converting enzyme inhibitors?  Journal Articles
• Anti-TNFα therapy in immune-mediated subfertility: State of the art  Journal Articles
• Anti-ischaemic effects of ACE inhibitors: review of current clinical evidence and ongoing clinical trials.  Journal Articles
• Anti-thrombotic options for secondary prevention in patients with chronic atherosclerotic vascular disease: what does COMPASS add?  Journal Articles
• Antibiotics: A New Hope  Journal Articles
• Antibody and cellular therapies for treatment of covid-19: a living systematic review and network meta-analysis  Journal Articles
• Anticoagulant therapy for the thrombotic complications of the antiphospholipid antibody syndrome  Conferences
• Anticoagulants in acute coronary syndromes  Journal Articles
• Anticoagulation for Atrial Fibrillation: State of the Art and Recommendations for a Quickly Moving Target  Journal Articles
• Antioxidants in the prevention of human atherosclerosis. Summary of the proceedings of a National Heart, Lung, and Blood Institute Workshop: September 5-6, 1991, Bethesda, Maryland.  Journal Articles
• Antiphospholipid antibiodies: a critical review of the literature  Journal Articles
• Antithrombotic Agents  Journal Articles
• Antithrombotic Agents in Coronary Artery Disease  Journal Articles
• Antithrombotic Therapy for Cerebrovascular Disorders  Journal Articles
• Antithrombotic Therapy in Coronary Ischaemia: The Expanding Role of Low-Molecular-Weight Heparin  Journal Articles
• Antithrombotic Therapy in Patients With Mechanical and Biological Prosthetic Heart Valves  Journal Articles
• Antithrombotic Therapy in Patients With Saphenous Vein and Internal Mammary Artery Bypass Grafts  Journal Articles
• Antithrombotic drug removal from whole blood using Haemoadsorption with a porous polymer bead sorbent  Journal Articles
• Antithrombotic effects of drugs which suppress platelet function: their potential in prevention growth of tumour cells.  Journal Articles
• Antithrombotic therapy for stroke prevention in non-valvular atrial fibrillation  Journal Articles
• Antithrombotic therapy: the expanding role of low molecular weight heparin.  Journal Articles
• Análisis interino en ensayos clínicos: una guía metodológica  Journal Articles
• Application of Epidemiological Methodology to Sports ana Exercise Science Research  Journal Articles
• Application of the systematic review and bibliometric network analysis (SeBriNA) methodology contextualizes evidence. Part 2: rituximab for non-Hodgkin's lymphoma  Journal Articles
• Applied pharmacoeconomics: considerations to drive the choice of a prophylactic antithrombotic regimen  Journal Articles
• Applying the findings of clinical trials to individual patients  Journal Articles
• Are Large Fracture Trials Possible?  Journal Articles
• Are clinical trials randomising households to lifestyle interventions to delay cognitive decline feasible? A pilot study to determine the beliefs, preferences, and deterrents for households impacted by dementia based on semi-structured interviews  Journal Articles
• Are placebo‐controlled trials ethical in areas where current guidelines recommend therapy? No  Journal Articles
• Are quality of life, patient preferences, and costs realistic outcomes for clinical trials?  Journal Articles
• Arteriovenous-Shunt Thrombosis  Journal Articles
• Aspiration thrombectomy in ST-elevation myocardial infarction  Journal Articles
• Aspirin Versus Low-Molecular-Weight Heparin for Ischemic Stroke in Children: An Unanswered Question  Journal Articles
• Aspirin and Other Platelet-Active Drugs  Conferences
• Aspirin and other platelet-active drugs. The relationship among dose, effectiveness, and side effects.  Journal Articles
• Aspirin in the treatment of cardiovascular disease: A review  Journal Articles
• Aspirin, Sulfinpyrazone, or Both in Unstable Angina  Journal Articles
• Assay of human stem cells by repopulation of NOD/SCID mice  Journal Articles
• Assessing Clinical Significance in Measuring Oncology Patient Quality of Life: Introduction to the Symposium, Content Overview, and Definition of Terms  Journal Articles
• Assessing sensitivity to change: choosing the appropriate change coefficient  Journal Articles
• Assessing the Methodological Quality of Nonrandomized Intervention Studies  Journal Articles
• Assessment and Treatment of Social Phobia  Journal Articles
• Assessment of quality of life in adolescents with allergic rhinoconjunctivitis: Development and testing of a questionnaire for clinical trials  Journal Articles
• Association between asymptomatic deep vein thrombosis detected by venography and symptomatic venous thromboembolism in patients undergoing elective hip or knee surgery  Journal Articles
• Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis  Journal Articles
• Association between physicians’ interaction with pharmaceutical companies and their clinical practices: A systematic review and meta-analysis  Journal Articles
• Association of Factor V Leiden With Subsequent Atherothrombotic Events  Journal Articles
• Association of handgrip strength to cardiovascular mortality in pre-diabetic and diabetic patients: A subanalysis of the ORIGIN trial  Journal Articles
• Asthma treatment: inhaled beta-agonists.  Journal Articles
• Attention to the principles of exercise training in exercise studies on prostate cancer survivors: a systematic review  Journal Articles
• Augmenting Insufficiently Accruing Oncology Clinical Trials Using Generative Models: Validation Study.  Journal Articles
• Auranofin therapy and quality of life in patients with rheumatoid arthritis. Results of a multicenter trial  Journal Articles
• Auricular acupuncture for analgesia after arthroscopy  Journal Articles
• Barriers and Facilitating Factors for Conducting Systematic Evidence Assessments in Academic Clinical Trials  Journal Articles
• Barriers to participation in HIV drug trials: a systematic review  Journal Articles
• Barriers to participation in clinical trials of cancer: a meta-analysis and systematic review of patient-reported factors  Journal Articles
• Barriers, Solutions, and Opportunities for Adapting Critical Care Clinical Trials in the COVID-19 Pandemic  Journal Articles
• Basic statistics for clinicians: 1. Hypothesis testing.  Journal Articles
• Basic statistics for clinicians: 2. Interpreting study results: confidence intervals.  Journal Articles
• Benefit of Selective Factor Inhibition  Journal Articles
• Beta blockade during and after myocardial infarction: An overview of the randomized trials  Journal Articles
• Beta-blocker therapy for congestive heart failure: a systemic overview and critical appraisal of the published trials.  Journal Articles
• Beta-blockers in immediate treatment of myocardial infarction  Journal Articles
• Better Treatments That Cost More: The Dilemma  Journal Articles
• Better engagement, better evidence: working in partnership with patients, the public, and communities in clinical trials with involvement and good participatory practice.  Journal Articles
• Beyond Mortality  Journal Articles
• Beyond Survival: Pediatric Critical Care Interventional Trial Outcome Measure Preferences of Families and Healthcare Professionals*  Journal Articles
• Beyond Unfractionated Heparin and Warfarin  Journal Articles
• Beyond heparin and warfarin: the new generation of anticoagulants  Journal Articles
• Bias in dissemination of clinical research findings: structured OPEN framework of what, who and why, based on literature review and expert consensus  Journal Articles
• Bias in transfusion research: from study design to result reporting  Journal Articles
• Bias towards dementia: Are hip fracture trials excluding too many patients? A systematic review  Journal Articles
• Bilateral vs. ipsilateral venography as the primary efficacy outcome measure in thromboprophylaxis clinical trials: a systematic review  Journal Articles
• Bimekizumab: The First Dual Inhibitor of Interleukin (IL)-17A and IL-17F for the Treatment of Psoriatic Disease and Ankylosing Spondylitis  Journal Articles
• Biosimilars for psoriasis: clinical studies to determine similarity  Journal Articles
• Bleeding Complications in Patients with Acute Coronary Syndromes: Are They Important and How Can We Prevent Them?  Journal Articles
• Bleeding complications in immune thrombocytopenia  Journal Articles
• Blocking the renin–angiotensin system: dual- versus mono-therapy  Journal Articles
• Blood Pressure Targets For Vasopressor Therapy  Journal Articles
• Breaking up is Hard to Do: The Heartbreak of Dichotomizing Continuous Data  Journal Articles
• Breast cancer in a BRCA2 mutation carrier with a history of prostate cancer  Journal Articles
• Briakinumab  Journal Articles
• Bronchoconstriction Stimulated by Airway Cooling  Journal Articles
• Bronchodilator delivery in acute airflow obstruction. A meta-analysis  Journal Articles
• Building clinical trial priorities at the University of Rwanda  Journal Articles
• CANadian Network and Centre for Trials INternationally (CANNeCTIN): A national network for Canadian-led trials in cardiovascular diseases and diabetes mellitus  Journal Articles
• COMMENTARY: Should Anti‐TNF‐α Therapy be Offered to Patients with Infertility and Recurrent Spontaneous Abortion?*  Journal Articles
• COMPARISON OF CARBONATED BUPIVACAINE AND BUPIVACAINE HYDROCHLORIDE FOR EXTRADURAL ANAESTHESIA  Journal Articles
• CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement  Journal Articles
• CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration  Journal Articles
• COVID-19 clinical trials: learning from exceptions in the research chaos.  Journal Articles
• CTS: A clinical trials simulator  Journal Articles
• Calcium and Vitamin D Therapy in Corticosteroid-Induced Bone Loss: What is the Evidence?  Conferences
• Can it work? Does it work? Is it worth it?  Journal Articles
• Can orthopedic trials change practice?  Journal Articles
• Can severity of symptoms be used as an outcome measure in trials of non-ulcer dyspepsia and helicobacter pylori associated gastritis?  Journal Articles
• Can simple clinical measurements detect patient noncompliance?  Journal Articles
• Can we differentiate the low-molecular-weight heparins?  Journal Articles
• Canadian Cardiovascular Society Consensus Conference guidelines on heart failure, update 2009: Diagnosis and management of right-sided heart failure, myocarditis, device therapy and recent important clinical trials  Journal Articles
• Canadian Guidelines for the Management of Acute Exacerbations of Chronic Bronchitis  Journal Articles
• Canadian multicenter randomized trial comparing sequential and alternating administration of two non-cross-resistant chemotherapy combinations in patients with limited small-cell carcinoma of the lung.  Journal Articles
• Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group  Journal Articles
• Cancer surveillance and control in adolescents—similarities and contrasts between Canada and the United States  Journal Articles
• Candesartan for the management of heart failure: more than an alternative  Journal Articles
• Carbenoxolone sodium in the treatment of gastric ulcer with special reference to side-effects.  Journal Articles
• Cardioembolic Stroke  Journal Articles
• Cardiovascular Risk in Patients with Early Renal Insufficiency  Journal Articles
• Cardiovascular Safety Of Nintedanib In Subgroups By Cardiovascular Risk At Baseline In The Tomorrow And Inpulsis Trials  Conferences
• Cardiovascular events in chronic myeloid leukemia clinical trials. Is it time to reassess and report the events according to cardiology guidelines?  Journal Articles
• Cardiovascular outcome trials in patients with chronic kidney disease: challenges associated with selection of patients and endpoints  Journal Articles
• Care models in the management of haemophilia: a systematic review  Journal Articles
• Carotid endarterectomy: three critical evaluations. North American Symptomatic Carotid Endarterectomy Study Group.  Journal Articles
• Carotid plaque formation and its evaluation with angiography, ultrasound, and MR angiography  Journal Articles
• Carryover and the Two-Period Crossover Clinical Trial  Journal Articles
• Cell encapsulation: Promise and progress  Journal Articles
• Central statistical monitoring: Detecting fraud in clinical trials  Journal Articles
• Cervical repening and labor induction with prostaglandin E2 gel: A placebo-controlled study  Journal Articles
• Challenges in Systematic Reviews That Evaluate Drug Efficacy or Effectiveness  Journal Articles
• Challenges in conducting clinical trials in nephrology: conclusions from a Kidney Disease—Improving Global Outcomes (KDIGO) Controversies Conference  Journal Articles
• Challenges in designing antirheumatic drug trials.  Journal Articles
• Challenges in evaluating surgical innovation  Journal Articles
• Challenges to complete and useful data sharing  Journal Articles
• Changes in Body Composition in Patients with Small-Cell Lung Cancer  Journal Articles
• Changes of Methodology in Clinical Trials of Sepsis Over Time  Journal Articles
• Characteristics of Interventional Trials for Patients Living With Intestinal Stoma Registered in ClinicalTrials.gov With a Focus on Inflammatory Bowel Disease  Journal Articles
• Characteristics that predicted recurrence of infarction within 3 years in the Ontario Exercise-Heart Collaborative Study.  Journal Articles
• Chemotherapy can prolong survival in patients with advanced non-small-cell lung cancer--report of a Canadian multicenter randomized trial.  Journal Articles
• Chinese Clinical Trial Registry: mission, responsibility and operation  Journal Articles
• Classification and appraisal of the level of clinical evidence of publications from the Canadian Association of Pediatric Surgeons for the past 10 years  Journal Articles
• Classification of the acute emetogenicity of chemotherapy in pediatric patients: A clinical practice guideline  Journal Articles
• Clinical Characteristics and Outcomes of Young and Very Young Adults With Heart Failure  Journal Articles
• Clinical Research: From Case Reports to International Multicenter Clinical Trials  Journal Articles
• Clinical Studies: Evidence for Intervention with Specific Antiplatelet Drugs in Arterial Thromboembolism  Journal Articles
• Clinical Trial Data Sharing for COVID-19–Related Research  Journal Articles
• Clinical Trial Design Considerations for Hospitalised Patients With Ulcerative Colitis Flares and Application to Study Hyperbaric Oxygen Therapy in the NIDDK HBOT-UC Consortium.  Journal Articles
• Clinical Trial Design in Acute Lung Injury—Issues and Controversies  Journal Articles
• Clinical Trial Evidence Supporting US Food and Drug Administration Approval of Novel Cancer Therapies Between 2000 and 2016  Journal Articles
• Clinical Trial Registration in Physical Therapy Journals: Recommendations from the International Society of Physiotherapy Journal Editors  Journal Articles
• Clinical Trial Registration in Physiotherapy Journals: Recommendations From the International Society of Physiotherapy Journal Editors  Journal Articles
• Clinical Trials in Cognitively Impaired Older Adults: Home versus Clinic Assessments  Journal Articles
• Clinical Use of Low Molecular Weight Heparins and Heparinoids  Journal Articles
• Clinical outcomes trials and the cardiovascular effects of thiazolidinediones: Implications for the evaluation of antidiabetic drugs  Journal Articles
• Clinical trial design in adult reflux disease: a methodological workshop  Journal Articles
• Clinical trial design in metastatic breast cancer: a commentary.  Journal Articles
• Clinical trial of chorion biopsy.  Journal Articles
• Clinical trial of common treatments for low back pain in family practice.  Journal Articles
• Clinical trial of deglydyrrhizinized liquorice in gastric ulcer.  Journal Articles
• Clinical trial registration in physical therapy journals: recommendations from the International Society of Physiotherapy Journal Editors  Journal Articles
• Clinical trial registration in physiotherapy journals: Recommendations from the International Society of Physiotherapy Journal Editors  Journal Articles
• Clinical trial registration in physiotherapy journals: recommendations from the International Society of Physiotherapy Journal Editors  Journal Articles
• Clinical trial registration in physiotherapy journals: recommendations from the International Society of Physiotherapy Journal Editors  Journal Articles
• Clinical trial update: National Cancer Institute of Canada  Journal Articles
• Clinical trials and haemophilia: does the Bayesian approach make the ideal and desirable good friends?  Journal Articles
• Clinical trials as diagnostic tests  Journal Articles
• Clinical trials of disease stages in COVID 19: complicated and often misinterpreted  Journal Articles
• Clinical trials update from the European Society of Cardiology Meeting 2009: AAA, RELY, PROTECT, ACTIVE‐I, European CRT survey, German pre‐SCD II registry, and MADIT‐CRT  Conferences
• Clinician-trialist rounds: 11. When your grant gets turned down – part 1: remorse, anger, and reconciliation  Journal Articles
• Clinician-trialist rounds: 24. Modernizing your introductory graduate course in clinical trials. Part 1: Commonsense meets evidence  Journal Articles
• Clinician-trialist rounds: 25. Designing an evidence-based introductory graduate course in clinical trials. Part 2: Applying the evidence to your RCT course design  Journal Articles
• Clopidogrel in acute coronary syndromes: Where are we now?  Journal Articles
• Clozapine and Psychosocial Function in Schizophrenia: A Systematic Review and Meta-Analysis  Journal Articles
• Colchicine for Secondary Prevention of Cardiovascular Disease  Journal Articles
• Collaborative cardiovascular clinical trials in Canada. The Canadian Cardiovascular Collaboration.  Journal Articles
• Combination 13-cis-retinoic acid and interferon alpha-2a in the therapy of solid tumors.  Journal Articles
• Combination chemotherapy and alpha-interferon in the treatment of Kaposi's sarcoma associated with acquired immune deficiency syndrome.  Journal Articles
• Combination chemotherapy confers modest survival advantage in patients with advanced non-small cell lung cancer: report of a Canadian multicenter randomized trial.  Journal Articles
• Combination chemotherapy using high or low dose methotrexate for small cell carcinoma of the lung — A randomised trial  Journal Articles
• Combining LABA and ICS in patients with severe COPD  Journal Articles
• Comment on the effectiveness of induction of labor for postterm pregnancy  Journal Articles
• Commentary on Cox CL, Lensing S, Rai SN et al. Proxy assessment of quality of life in pediatric clinical trials: Application of the Health Utilities Index 3. Qual Life Res 2005; 14: 1045–1056  Journal Articles
• Commentary on Jack Dowie, “Decision validity should determine whether a generic or condition‐specific HRQOL measure is used in health care decisions”  Journal Articles
• Commentary: The Once and Future Psychiatry  Journal Articles
• Comparative Therapeutic Studies with Tilavist  Journal Articles
• Comparative effectiveness and safety of the novel oral anticoagulants: do the pivotal clinical trials point to a new paradigm?  Journal Articles
• Comparative efficacy and safety of first-line antiretroviral therapy for the treatment of HIV infection: a systematic review and network meta-analysis  Journal Articles
• Comparative tolerability of treatments for acute migraine: A network meta-analysis  Journal Articles
• Comparative tolerability of two formulations of Rhinalar (flunisolide) nasal spray in patients with seasonal allergic rhinitis.  Journal Articles
• Comparison of 12 Risk Stratification Schemes to Predict Stroke in Patients With Nonvalvular Atrial Fibrillation  Journal Articles
• Comparison of Arthroplasty Trial Publications After Registration in ClinicalTrials.gov  Journal Articles
• Comparison of High-Dose with Low-Dose Subcutaneous Heparin to Prevent Left Ventricular Mural Thrombosis in Patients with Acute Transmural Anterior Myocardial Infarction  Journal Articles
• Comparison of published orthopaedic trauma trials following registration in Clinicaltrials.gov  Journal Articles
• Comparison of ranitidine and cimetidine maintenance treatment of duodenal ulcer.  Journal Articles
• Comparison of the Effects of Nebulized Terbutaline with Intravenous Enprofylline in Patients with Acute Asthma  Journal Articles
• Comparison of twice-daily ranitidine with standard cimetidine treatment of duodenal ulcer.  Journal Articles
• Comparison of two chamber devices in patients using a metered-dose inhaler with satisfactory technique.  Journal Articles
• Complete or Incomplete Revascularization for ST-Segment Elevation Myocardial Infarction  Journal Articles
• Complex Limb Salvage or Early Amputation for Severe Lower-Limb Injury: A Meta-Analysis of Observational Studies  Journal Articles
• Compliance With Guideline-Directed Medical Therapy in Contemporary Coronary Revascularization Trials  Journal Articles
• Composite outcomes in clinical trials: what are they and when should they be used?  Journal Articles
• Con: Meta-analysis: some key limitations and potential solutions  Journal Articles
• Conducting economic evaluations alongside multinational clinical trials: Toward a research consensus  Journal Articles
• Conducting industry-partnered trials in orthopaedic surgery  Journal Articles
• Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients  Journal Articles
• Consistently Estimating Absolute Risk Difference when Translating Evidence to Jurisdictions of Interest  Journal Articles
• Continuing Challenges of Sepsis Research  Journal Articles
• Continuous Intravenous Heparin Compared with Intermittent Subcutaneous Heparin in the Initial Treatment of Proximal-Vein Thrombosis  Journal Articles
• Controlled comparison of cimetidine and carbenoxolone sodium in gastric ulcer.  Journal Articles
• Conventional and Complementary Therapies: A Tale of Two Research Standards?  Journal Articles
• Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery  Journal Articles
• Core Outcome Set for IgE‐mediated food allergy clinical trials and observational studies of interventions: International Delphi consensus study ‘COMFA’  Journal Articles
• Core outcome set for gene therapy in haemophilia: Results of the coreHEM multistakeholder project  Journal Articles
• Corticosteroid-Induced Osteoporosis  Journal Articles
• Cost Effectiveness of a Survivorship Care Plan for Breast Cancer Survivors  Journal Articles
• Cost effectiveness and equity are ignored  Journal Articles
• Cost-Effectiveness of Pharmaceutical Management for Osteoarthritis Pain  Journal Articles
• Cost-effectiveness analysis for multinational clinical trials  Journal Articles
• Cost-effectiveness of pregabalin for the management of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia: A Canadian perspective  Journal Articles
• Costs of Outpatient Anticoagulant Treatment in Patients with Cerebral and Peripheral Arterial Occlusive Disease  Journal Articles
• Cost‐effectiveness analysis when the WTA is greater than the WTP  Journal Articles
• Criteria for clinically important changes in outcomes: development, scoring and evaluation of rheumatoid arthritis patient and trial profiles. OMERACT Committee.  Journal Articles
• Criteria for use of composite end points for competing risks—a systematic survey of the literature with recommendations  Journal Articles
• Critical evaluation of platelet-inhibiting drugs in thrombotic disease.  Journal Articles
• Critical review of the approaches to the prevention of sudden death  Journal Articles
• Current quality-of-life research challenges in arthritis relevant to the issue of clinical significance  Journal Articles
• Current state of quality of life and patient-reported outcomes research  Journal Articles
• Curtailing the Use of Preregistration: A Misused Term.  Journal Articles
• Cutaneous Adverse Events and Gemifloxacin: Observations from the Clinical Trial Program  Journal Articles
• Cutaneous responses to tests with influenza vaccines.  Journal Articles
• Cyclooxygenase-2 Inhibitors  Journal Articles
• Cyclooxygenase-2 Inhibitors in Colorectal Cancer Prevention: Counterpoint  Journal Articles
• Cyclophosphamide, doxorubicin, and cisplatin in the treatment of non-small cell bronchogenic carcinoma.  Journal Articles
• DEVELOPMENT OF ANTI-IDIOTYPIC ANTIBODIES AGAINST TUMOUR ANTIGENS AND AUTOANTIGENS IN OVARIAN CANCER PATIENTS TREATED INTRAPERITONEALLY WITH MOUSE MONOCLONAL ANTIBODIES  Journal Articles
• DOES MORE FETAL MONITORING MEAN MORE CESAREANS - META-ANALYSIS OF A MEDICAL PROBLEM  Journal Articles
• DOUBLE-BLIND RANDOMISED TRIAL OF ORG 10172 LOW-MOLECULAR-WEIGHT HEPARINOID IN PREVENTION OF DEEP-VEIN THROMBOSIS IN THROMBOTIC STROKE  Journal Articles
• Dabigatran in clinical practice: Contemporary overview of the evidence  Journal Articles
• Dabigatran versus rivaroxaban for the prevention of stroke and systemic embolism in atrial fibrillation in Canada  Journal Articles
• Daily Hemodialysis  Journal Articles
• Daily Inhaled Corticosteroid Treatment Should Be Prescribed for Mild Persistent Asthma  Journal Articles
• Daily Inhaled Corticosteroid Treatment Should Not Be Prescribed for Mild Persistent Asthma  Journal Articles
• Data collection in cancer clinical trials: Too much of a good thing?  Journal Articles
• Data-Sharing Statements Requested from Clinical Trials by Public, Environmental, and Occupational Health Journals: Cross-Sectional Study.  Journal Articles
• David Sackett's Unintended Impacts on Health Policy  Journal Articles
• Declining Enrolment and Other Challenges in IBD Clinical Trials: Causes and Potential Solutions  Journal Articles
• Defining high bleeding risk in patients undergoing percutaneous coronary intervention: a consensus document from the Academic Research Consortium for High Bleeding Risk  Journal Articles
• Delaying and withholding interventions: ethics and the stepped wedge trial  Journal Articles
• Design Considerations in Crossover Trials with a Single Interim Analysis and Serial Patient Entry  Journal Articles
• Design and Rationale of Health-Related Quality of Life and Patient-Reported Outcomes Assessment in the Frequent Hemodialysis Network Trials  Conferences
• Design and assessment of clinical trials on continuous infusion.  Conferences
• Design, Conduct, and Interpretation of Nonrandomized Orthopaedic Studies: A Practical Approach  Journal Articles
• Design, analysis and reporting of multi-arm trials and strategies to address multiple testing  Conferences
• Designing research in vulnerable populations: lessons from HIV prevention trials that stopped early  Journal Articles
• Determination of ReQuest^TM-Based Symptom Thresholds to Define Symptom Relief in GERD Clinical Studies  Journal Articles
• Determining Optimal Therapy — Randomized Trials in Individual Patients  Journal Articles
• Determining Optimal Therapy — Randomized Trials in Individual Patients  Journal Articles
• Determining causation—A case study: Adrenocorticosteroids and osteoporosis  Journal Articles
• Determining the sample size in a clinical trial  Journal Articles
• Developing Effective Services for Patients with Personality Disorders  Journal Articles
• Developing a framework to incorporate real-world evidence in cancer drug funding decisions: the Canadian Real-world Evidence for Value of Cancer Drugs (CanREValue) collaboration  Journal Articles
• Developing and Implementing Performance Outcome Assessments: Evidentiary, Methodologic, and Operational Considerations  Journal Articles
• Development and initial validation of a new preference-based disease-specific health-related quality of life instrument for erectile function  Journal Articles
• Development and testing of a new measure of health status for clinical trials in heart failure  Journal Articles
• Development and testing of a new measure of health status for clinical trials in rhinoconjunctivitis  Journal Articles
• Development of a generic fidelity measure for rehabilitation intervention research for children with physical disabilities  Journal Articles
• Diabetes clinical trials: helped or hindered by the current shift in regulatory requirements?  Journal Articles
• Diagnostic Approach to Evaluating the Cause of a Positive Fecal Occult Blood Test  Journal Articles
• Diagnostic Efficacy of Impedance Plethysmography for Clinically Suspected Deep-Vein Thrombosis  Journal Articles
• Dialyzer Re-Use – A Multiple Crossover Study with Random Allocation to Order of Treatment  Journal Articles
• Dietary Saturated Fats and Health: Are the U.S. Guidelines Evidence-Based?  Journal Articles
• Different Intensities of Oral Anticoagulant Therapy in the Treatment of Proximal-Vein Thrombosis  Journal Articles
• Differential power of placebo across major psychiatric disorders: a preliminary meta-analysis and machine learning study  Journal Articles
• Dificultades en la interpretación de los resultados de la investigación biomédica relacionada con el manejo de pacientes con enfermedades crónicas no transmisibles  Journal Articles
• Digital tools for trial recruitment and retention—plenty of tools but rigorous evaluation is in short supply  Journal Articles
• Digitalis--a new controversy regarding an old drug. The pitfalls of inappropriate methods.  Journal Articles
• Diltiazem cardioplegia  Journal Articles
• Direct Factor Xa and direct thrombin inhibitors: a clinical trial update.  Journal Articles
• Direct Thrombin Inhibitors in Acute Coronary Syndromes  Journal Articles
• Direct thrombin inhibitors  Journal Articles
• Direct thrombin inhibitors in acute coronary syndromes  Journal Articles
• Discrimination of changes in osteoporosis outcomes.  Conferences
• Discussion  Conferences
• Diversity in enrollment to clinical trials for cataract medicine and surgery: meta-analysis  Journal Articles
• Do children with central venous line (CVL) dysfunction have increased risk of symptomatic thromboembolism compared to those without CVL-dysfunction, while on cancer therapy?  Journal Articles
• Do editors live up to the Sept 10, 2001, expectations?  Journal Articles
• Doctor, can we prevent food allergy and eczema in our baby?  Journal Articles
• Does Routine Newborn Bathing Reduce Staphylococcus aureus Colonization Rates? A Randomized Controlled Trial  Journal Articles
• Does therapy directed by programmed electrical stimulation provide a satisfactory clinical response?  Journal Articles
• Dose Antiplatelet Agents; The Relationship Among Side Effects, and Antithrombotic Effectiveness  Journal Articles
• Dose Capping Enoxaparin Is Unjustified and Denies Patients With Acute Coronary Syndromes a Potentially Effective Treatment  Journal Articles
• Double blind, you are the weakest link - goodbye!  Journal Articles
• Double-blind, placebo-controlled studies of bulimic patients.  Journal Articles
• Doxycycline and other tetracyclines in the treatment of bone metastasis  Journal Articles
• Driving Ability After Intravenous Fentanyl or Diazepam  Journal Articles
• Drug combinations: a strategy to extend the life of antibiotics in the 21st century  Journal Articles
• Drug related adverse event assessment in neonates in clinical trials and clinical care  Journal Articles
• Dual-Chamber Versus Ventricular Pacing  Journal Articles
• EARLY INTRAVENOUS ATENOLOL TREATMENT IN SUSPECTED ACUTE MYOCARDIAL INFARCTION  Journal Articles
• EARLY INTRAVENOUS ATENOLOL TREATMENT IN SUSPECTED ACUTE MYOCARDIAL INFARCTION  Journal Articles
• EFFECT OF ATENOLOL ON RECOVERY OF THE ELECTROCARDIOGRAPHIC SIGNS OF MYOCARDIAL INFARCTION  Journal Articles
• EFFECT OF INTRAVENOUS NITRATES ON MORTALITY IN ACUTE MYOCARDIAL INFARCTION: AN OVERVIEW OF THE RANDOMISED TRIALS  Journal Articles
• EPM-ROM Scale: an evaluative instrument to be used in rheumatoid arthritis trials.  Journal Articles
• Early Intravenous Beta-Blockade in Acute Myocardial Infarction  Journal Articles
• Early intravenous beta blockade in acute myocardial infarction.  Journal Articles
• Early stage ovarian cancer: a randomized clinical trial comparing whole abdominal radiotherapy, melphalan, and intraperitoneal chromic phosphate: a National Cancer Institute of Canada Clinical Trials Group report.  Journal Articles
• Echocardiographic Predictors of Stroke in Patients With Atrial Fibrillation  Journal Articles
• Echocardiographic evaluation of left ventricular function in patients showing an antihypertensive and biochemical response to indapamide.  Journal Articles
• Economic analysis and clinical trials  Journal Articles
• Economic evaluation of nivolumab for the treatment of second-line advanced squamous NSCLC in Canada: a comparison of modeling approaches to estimate and extrapolate survival outcomes  Journal Articles
• Effect of Digoxin on Right Ventricular Function in Severe Chronic Airflow Obstruction  Journal Articles
• Effect of Drug Therapy on Survival in Chronic Heart Failure  Journal Articles
• Effect of Intravenous Streptokinase on Acute Myocardial Infarction  Journal Articles
• Effect of adjuvant central iv hyperalimentation on the survival and response to treatment of patients with small cell lung cancer: a randomized trial.  Journal Articles
• Effect of beclomethasone dipropionate on bronchial responsiveness to histamine in controlled nonsteroid-dependent asthma  Journal Articles
• Effect of diuretics on cardiopulmonary performance in severe chronic airflow obstruction. A controlled clinical trial  Journal Articles
• Effect of drug therapy on survival in chronic congestive heart failure  Journal Articles
• Effect of incretin-based therapies on cancers of digestive system among 101 595 patients with type 2 diabetes mellitus: a systematic review and network meta-analysis combining 84 trials with a median duration of 30 weeks  Journal Articles
• Effect of indomethacin on allergen-induced asthmatic responses  Journal Articles
• Effect of nafazatrom on platelet function and release: Relationship to symptomatic episodes in patients with peripheral vascular disease  Journal Articles
• Effect of suloctidil on platelet function in patients with shortened platelet. Survival time  Journal Articles
• Effect of vasodilators on survival in chronic congestive heart failure  Journal Articles
• Effectiveness of Anticoagulants  Journal Articles
• Effectiveness of Percutaneous Coronary Intervention in Patients With Silent Myocardial Ischemia (Post Hoc Analysis of the COURAGE Trial)  Journal Articles
• Effects of ACE inhibitors and angiotensin receptor blockers: protocol for a UK cohort study using routinely collected electronic health records with validation against the ONTARGET trial  Journal Articles
• Effects of Aerobic Dance on Cognition in Older Adults with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis  Journal Articles
• Effects of Computerized Clinical Decision Support Systems on Practitioner Performance and Patient Outcomes  Journal Articles
• Effects of Methandienone on the Performance and Body Composition of Men Undergoing Athletic Training  Journal Articles
• Effects of Radiotherapy in Early-Stage, Low-Recurrence Risk, Hormone-Sensitive Breast Cancer  Journal Articles
• Effects of aspirin, naloxone and placebo  Journal Articles
• Effects of exercise training in patients with congestive heart failure: A critical review  Journal Articles
• Effects of exercise training on cognition in chronic obstructive pulmonary disease: A systematic review  Journal Articles
• Effects of hemodialysis and hypertonic hemodiafiltration on cardiac function compared  Journal Articles
• Effects of post-ICU follow-up on subject outcomes: A systematic review and meta-analysis  Journal Articles
• Effects of prophylactic lidocaine in suspected acute myocardial infarction. An overview of results from the randomized, controlled trials  Journal Articles
• Effects of study design and trends for EVAR versus OSR  Journal Articles
• Effects of temperature and substrate concentration on the LDH/α-HBD ratio in heart and liver disease  Journal Articles
• Effects of  -blockers and calcium channel blockers in acute myocardial infarction  Journal Articles
• Efficacy and Safety of Gemcitabine Plus Either Taxane or Carboplatin in the First-Line Setting of Metastatic Urothelial Carcinoma: A Systematic Review and Meta-Analysis  Journal Articles
• Efficacy and Safety of Pegylated Interferon Alfa-2a or Alfa-2b Plus Ribavirin for the Treatment of Chronic Hepatitis C in Children and Adolescents: A Systematic Review and Meta-analysis  Journal Articles
• Efficacy and safety of convalescent plasma for severe COVID-19 based on evidence in other severe respiratory viral infections: a systematic review and meta-analysis  Journal Articles
• Efficacy of progesterone support for pregnancy in women with recurrent miscarriage. A meta‐analysis of controlled trials  Journal Articles
• Efficacy of progesterone support in the luteal phase following in-vitro fertilization and embryo transfer: meta-analysis of clinical trials  Journal Articles
• El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos  Journal Articles
• Elimination of 4-n-Butoxyphenylacethydroxamic Acid (Bufexamac) in Man  Journal Articles
• Emergence of the Primary Pediatric Stroke Center  Journal Articles
• Emerging therapeutic options for the treatment of patients with symptomatic asthma  Journal Articles
• Ending COVID-19: progress and gaps in research—highlights of the July 2020 GloPID-R COVID-19 Research Synergies Meetings  Journal Articles
• Ending Gender Inequality in Cardiovascular Clinical Trial Leadership  Journal Articles
• Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: A meta-analysis  Journal Articles
• Endoscopic treatments for gastro-oesophageal reflux disease  Journal Articles
• Enoxaparin in the Treatment of Deep Vein Thrombosis With or Without Pulmonary Embolism  Journal Articles
• Enrolling Women into HIV Preventive Vaccine Trials: An Ethical Imperative but a Logistical Challenge  Journal Articles
• Epidermal Growth Factor Receptor: Pathway, Therapies, and Pipeline  Journal Articles
• Epidermal growth factor receptors and cyclooxygenase-2 in the pathogenesis of non-small cell lung cancer: potential targets for chemoprevention and systemic therapy  Journal Articles
• Epidural analgesia during labour.  Journal Articles
• Eradication of Helicobacter pylori infection in the management of patients with dyspepsia and non-ulcer dyspepsia.  Journal Articles
• Estimating per patient funding for cancer clinical trials: An Ontario based survey  Journal Articles
• Estimating the Power of Indirect Comparisons: A Simulation Study  Journal Articles
• Estimating the number needed to treat (NNT) index when the data are subject to error  Journal Articles
• Ethical Aspects in Trials of Implantable Medical Devices  Journal Articles
• Ethical Gifts?: An Analysis of Soap‐for‐data Transactions in Malawian Survey Research Worlds  Journal Articles
• Ethical communication in clinical trials  Journal Articles
• Ethical considerations in international HIV vaccine trials: summary of a consultative process conducted by the Joint United Nations Programme on HIV/AIDS (UNAIDS)  Journal Articles
• Etretinate Blood Levels in Monitoring of Compliance and Contamination in a Chemoprevention Trial  Journal Articles
• Evaluating early intervention in smoldering myeloma clinical trials: a systematic review.  Journal Articles
• Evaluating the Value of Number of Cycles of Docetaxel and Prednisone in Men With Metastatic Castration-Resistant Prostate Cancer  Journal Articles
• Evaluating the role of quality assessment of primary studies in systematic reviews of cancer practice guidelines  Journal Articles
• Evaluation of Disodium Cromoglycate in Intrinsic and Extrinsic Asthma^1–3  Journal Articles
• Evaluation of Neonatal-Intensive-Care Programs  Journal Articles
• Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials.  Journal Articles
• Evaluation of intervention reporting in published emergency medicine clinical trials  Journal Articles
• Evaluation of the Effectiveness of Suicide Prevention Programs: A Methodological Perspective  Journal Articles
• Evaluation of the addition of cromolyn sodium to bronchodilator maintenance therapy in the long-term management of asthma  Journal Articles
• Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis  Journal Articles
• Everything You Ever Wanted to Know About Evidence-based Medicine  Journal Articles
• Evidence and values: requirements for public reimbursement of drugs for rare diseases--a case study in oncology.  Journal Articles
• Evidence base of clinical diagnosis: The architecture of diagnostic research  Journal Articles
• Evidence based critical care medicine  Journal Articles
• Evidence based treatment of the antiphospholipid syndromeII. Optimal anticoagulant therapy for thrombosis  Journal Articles
• Evidence-Based Approach to the Introduction of Positron Emission Tomography in Ontario, Canada  Journal Articles
• Evidence-Based Laboratory Medicine: Addressing Bias, Generalisability and Applicability in Studies on Diagnostic Accuracy. The STARD Initiative  Journal Articles
• Evidence-Based Medicine  Journal Articles
• Evidence-Based Neonatal Drug Therapy for Prevention of Bronchopulmonary Dysplasia in Very-Low-Birth-Weight Infants  Journal Articles
• Evidence-based medicine  Journal Articles
• Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: Report of a Task Force at the 13th International Congress on Antiphospholipid Antibodies  Journal Articles
• Evidence-based treatment of the antiphospholipid syndrome  Journal Articles
• Evidence-based urology: importance of relative vs absolute effect  Journal Articles
• Evidence‐based clinical reporting: a need for improvement  Journal Articles
• Evolution of Heterogeneity (I2) Estimates and Their 95% Confidence Intervals in Large Meta-Analyses  Journal Articles
• Evolution of Oncolytic Viruses: Novel Strategies for Cancer Treatment  Journal Articles
• Examining the evidence in anesthesia literature: a survey and evaluation of obstetrical postdural puncture headache reports  Journal Articles
• Excessive Use of Normal Saline in Managing Traumatized Patients in Shock: A Preventable Contributor to Acidosis  Journal Articles
• Exercising women throw a wrench in the gears of the AMPK–lipid oxidation link  Journal Articles
• Expected value of information and decision making in HTA  Journal Articles
• Expert Consensus Document on the Use of Antiplatelet Agents The Task Force on the Use of Antiplatelet Agents in Patients with Atherosclerotic Cardiovascular Disease of the European Society of Cardiology  Journal Articles
• Expertise-based design in surgical trials: a narrative review  Journal Articles
• Exploring factors associated with views on sharing of certain interim trial result measures by the data safety monitoring board (DSMB) with non-DSMB members  Journal Articles
• Extended Adjuvant Endocrine Therapy in Breast Cancer: Current Status and Future Directions  Journal Articles
• Extension of anticoagulation after venous thromboembolism  Journal Articles
• External Fixation Versus Internal Fixation for Unstable Distal Radius Fractures  Journal Articles
• FACE-Q Scales for Health-Related Quality of Life, Early Life Impact, Satisfaction with Outcomes, and Decision to Have Treatment  Journal Articles
• FACE-Q scales for health-related quality of life, early life impact, satisfaction with outcomes, and decision to have treatment: development and validation.  Journal Articles
• FDA ovarian cancer clinical trial endpoints workshop: A Society of Gynecologic Oncology White Paper  Journal Articles
• Factor VIII concentrate for hemophilia: comparison of two heat-treated products.  Journal Articles
• Factor Xa and thrombin as targets for new oral anticoagulants  Journal Articles
• Factor Xa or thrombin: Is thrombin a better target?  Conferences
• Factors influencing the quality of clinical trials on traditional Chinese medicine—Qualitative interviews with trial auditors, clinicians and academic researchers  Journal Articles
• Factors of Importance for QRS Complex Recovery after Acute Myocardial Infarction  Journal Articles
• Failure of 5-day vinblastine infusion in the treatment of patients with renal cell carcinoma.  Journal Articles
• Failure of Weight Reduction to Reduce Mildly Elevated Blood Pressure: A Randomized Trial  Journal Articles
• Failure of methylprednisolone acetate to prolong the antinauseant effect of intravenous methylprednisolone sodium succinate in patients receiving chemotherapy.  Journal Articles
• Fair, just and compassionate: A pilot for making allocation decisions for patients requesting experimental drugs outside of clinical trials  Journal Articles
• False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review  Journal Articles
• Favorable Pharmacokinetic Characteristics of Extended-Half-Life Recombinant Factor VIII BAY 94-9027 Enable Robust Individual Profiling Using a Population Pharmacokinetic Approach  Journal Articles
• Feasibility of real time next generation sequencing of cancer genes linked to drug response: Results from a clinical trial  Journal Articles
• Febrile nonhemolytic transfusion reactions to platelets  Journal Articles
• Fetal globin gene inducers: novel agents and new potential  Journal Articles
• Fetal growth restriction  Journal Articles
• Finding a Contract Research Organization for Your Research Trial  Journal Articles
• First do no harm: extending the debate on the provision of preventive tamoxifen  Journal Articles
• Fluid Lavage of Open Wounds (FLOW): design and rationale for a large, multicenter collaborative 2 × 3 factorial trial of irrigating pressures and solutions in patients with open fractures  Journal Articles
• Focused 2012 Update of the Canadian Cardiovascular Society Atrial Fibrillation Guidelines: Recommendations for Stroke Prevention and Rate/Rhythm Control  Journal Articles
• Focused 2012 Update of the Canadian Cardiovascular Society Guidelines for the Use of Antiplatelet Therapy  Journal Articles
• Folic Acid–Based Multivitamin Therapy to Prevent Stroke  Journal Articles
• Fondaparinux and prevention of venous thromboembolism after orthopaedic surgery  Journal Articles
• Fondaparinux: a Factor Xa inhibitor for antithrombotic therapy  Journal Articles
• Four Part Fractures of the Proximal Humerus  Journal Articles
• Frailty measures in multiple myeloma: evaluating the impact on outcomes and quality-of-life in clinical trials and real-world practice.  Journal Articles
• Frequency of administration of short half-life nonsteroidal anti-inflammatory analgesics (NSAID's): studies with ibuprofen.  Journal Articles
• From Trousseau to targeted therapy: new insights and innovations in thrombosis and cancer  Journal Articles
• From the Bench to the Bedside: The Future of Sepsis Research  Conferences
• From the hope to the ontarget and the transcend studies: challenges in improving prognosis  Journal Articles
• Fructose vs. glucose and metabolism  Journal Articles
• Functional compensation in partially denervated muscles  Journal Articles
• Functional status changes following medical or surgical treatment for cerebral ischemia. Results of the extracranial-intracranial bypass study  Journal Articles
• Funding New Cancer Drugs in Ontario: Closing the Loop in the Practice Guidelines Development Cycle  Journal Articles
• Funding Oncology Clinical Trials: Are Cooperative Group Trials Sustainable?  Journal Articles
• Further conclusions from the extracranial-intracranial bypass trial  Journal Articles
• Future Directions for Research onSilybum marianumfor Cancer Patients  Journal Articles
• Future Perspectives: The Need for Large Clinical Trials  Journal Articles
• Future letters—“Workshops on internet”  Journal Articles
• GA²LEN (Global Allergy and Asthma European Network) addresses the allergy and asthma ‘epidemic’  Journal Articles
• GRADE guidelines: 18. How ROBINS-I and other tools to assess risk of bias in nonrandomized studies should be used to rate the certainty of a body of evidence  Journal Articles
• Gastric Alkalinization, Pneumonia, and Systemic Infections: The Controversy  Journal Articles
• Gastric acidity and preneoplastic/neoplastic changes of the stomach.  Journal Articles
• Gemcitabine/Dexamethasone/Cisplatin vs Cytarabine/Dexamethasone/Cisplatin for Relapsed or Refractory Aggressive-Histology Lymphoma: Cost-Utility Analysis of NCIC CTG LY.12  Journal Articles
• Gene Therapy: Socioeconomic and Ethical Issues A Roundtable Discussion  Journal Articles
• Generalizability of results from the recent FDA-guided cardiovascular outcomes trials to a representative population with Type 2 Diabetes attending primary care clinics  Journal Articles
• Generalizing the Results of Cancer Clinical Trials  Journal Articles
• Getting intimate with the venous thrombus  Journal Articles
• Getting oncolytic virus therapies off the ground  Journal Articles
• Goodbye, number needed to treat?  Journal Articles
• Growth Hormone Therapy in Heart Failure: Where Are We Now?  Journal Articles
• Guidelines for Reporting Outcomes in Trial Protocols  Journal Articles
• Guidelines for Reporting Outcomes in Trial Reports  Journal Articles
• Guidelines for Reporting Reliability and Agreement Studies (GRRAS) were proposed  Journal Articles
• Guidelines for clinical trials in Helicobacter pylori infection. Working Party of the European Helicobacter pylori Study Group.  Journal Articles
• Guidelines for fracture healing assessments in clinical trials. Part I: Definitions and endpoint committees  Journal Articles
• Guidelines for osteoporosis trials.  Journal Articles
• Guidelines for the Clinical and Economic Assessment of Health Technologies  Journal Articles
• Guidelines for the clinical and economic evaluation of health care technologies  Journal Articles
• HOPE­‑3, BP treatment, milestones in CV prevention. Dr. Salim Yusuf in an interview with Dr. Akbar Panju and Dr. Roman Jaeschke  Journal Articles
• HSV-2 vaccine: Current state and insights into development of a vaccine that targets genital mucosal protection  Journal Articles
• Haemorrhagic and Thromboembolic Complications versus Intensity of Treatment of Venous Thromboembolism with Oral Anticoagulants  Journal Articles
• Haemorrhagic and thromboembolic complications versus intensity of treatment of venous thromboembolism with oral anticoagulants.  Journal Articles
• Handling of Missing Data  Journal Articles
• Health Equity Considerations for Developing and Reporting Patient-reported Outcomes in Clinical Trials: A Report from the OMERACT Equity Special Interest Group  Journal Articles
• Heart failure and cognitive impairment: challenges and opportunities.  Journal Articles
• Heart failure and shock complicating acute coronary syndromes  Journal Articles
• Helicobacter pylori: a clinical update  Journal Articles
• Hemorrhagic Complications of Anticoagulant Therapy  Journal Articles
• Hemorrhagic Complications of Anticoagulant Treatment  Journal Articles
• Hemorrhagic Complications of Long-term Anticoagulant Therapy  Journal Articles
• Hemorrhagic Complications of Thrombolytic Therapy in the Treatment of Myocardial Infarction and Venous Thromboembolism  Conferences
• Hemorrhagic complications of anticoagulant treatment.  Journal Articles
• Hemorrhagic complications of long-term anticoagulant therapy for ischemic cerebral vascular disease.  Journal Articles
• Hemorrhagic complications of long-term anticoagulant therapy.  Journal Articles
• Hemorrhagic complications of thrombolytic therapy in the treatment of myocardial infarction and venous thromboembolism.  Journal Articles
• Heparin in the Treatment of Thromboembolic Stroke  Journal Articles
• Heparin induced bleeding.  Journal Articles
• Heparin-induced thrombocytopenia in the critical care setting: Diagnosis and management^  Journal Articles
• Heparin: Mechanism of Action, Pharmacokinetics, Dosing Considerations, Monitoring, Efficacy, and Safety  Journal Articles
• Heparin: mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety.  Journal Articles
• Herb-Drug Interaction Implications in Pediatric Practice: An Overview of Pharmacokinetic Trials  Journal Articles
• Heroin vs morphine for cancer pain?  Journal Articles
• Heterogeneous Effects of Fructose on Blood Lipids in Individuals With Type 2 Diabetes  Journal Articles
• Heterologous boost vaccines for bacillus Calmette-Guérin prime immunization against tuberculosis.  Journal Articles
• Heterologous boost vaccines for bacillus Calmette–Guérin prime immunization against tuberculosis  Journal Articles
• Hierarchy of Evidence: A Simple System for Orthopaedic Research?  Journal Articles
• Hierarchy of Evidence: Where Observational Studies Fit in and Why We Need Them  Journal Articles
• High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies.  Journal Articles
• High‐dose cytosine arabinoside in the treatment of preleukemic disorders: A leukemia intergroup study  Journal Articles
• Hirudin and thrombosis prophylaxis  Journal Articles
• Homologous artificial insemination for oligoasthenospermia: a randomized controlled study comparing intracervical and intrauterine techniques  Journal Articles
• Honesty, Trust, and Respect During Consent Discussions in Neonatal Clinical Trials  Journal Articles
• Hormonal responses to zimelidine and desipramine in depressed patients  Journal Articles
• How Generalizable Are the Results From Trials of Direct Antiviral Agents to People Coinfected With HIV/HCV in the Real World?  Journal Articles
• How Should Results from Completed Studies Influence Ongoing Clinical Trials?  Journal Articles
• How a well-grounded minimal important difference can enhance transparency of labelling claims and improve interpretation of a patient reported outcome measure  Journal Articles
• How have research questions and methods used in clinical trials published in Clinical Rehabilitation changed over the last 30 years?  Journal Articles
• How to Integrate Multiple Comorbidities in Guideline Development  Conferences
• How to make cardiology clinical trials more inclusive.  Journal Articles
• How to optimize participant retention and complete follow-up in surgical research  Journal Articles
• How to use articles about harm  Journal Articles
• Human Gene Marker/Therapy Clincal Protocols (Complete Updated Listings)  Journal Articles
• Hyperprogressive disease in early-phase immunotherapy trials: Clinical predictors and association with immune-related toxicities.  Journal Articles
• Hypertension as an Underlying Factor in Heart Failure With Preserved Ejection Fraction  Journal Articles
• Hypothesis Testing in Superiority, Noninferiority, and Equivalence Clinical Trials  Journal Articles
• Hypothesis testing and sample size for bivariate binomial response in the comparison of two groups  Journal Articles
• IMPROVEMENT OF MEDICATION COMPLIANCE IN UNCONTROLLED HYPERTENSION  Journal Articles
• Iatrogenic causes of an ICH  Journal Articles
• Identification and Evaluation of Controlled Trials in Pediatric Cardiology: Crowdsourced Scoping Review and Creation of Accessible Searchable Database  Journal Articles
• Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology [see comments]  Journal Articles
• Imipenem: a new carbapenem. Committee on Antimicrobial Agents, Canadian Infectious Disease Society.  Journal Articles
• Immune checkpoint-inhibitors and chemoradiation in stage III unresectable non-small cell lung cancer  Journal Articles
• Immuno-gene therapy approaches for cancer: from in vitro studies to clinical trials  Journal Articles
• Immunological considerations for COVID-19 vaccine strategies  Journal Articles
• Immunotherapy for recurrent miscarriage.  Journal Articles
• Immunotherapy in the Elderly  Journal Articles
• Immunotherapy with peptides.  Journal Articles
• Impact and Perceptions of Mandatory Tumor Biopsies for Correlative Studies in Clinical Trials of Novel Anticancer Agents  Conferences
• Impact of 5-HT3 receptor antagonists on peripheral and central diseases  Journal Articles
• Impact of ENIGMA trials on nitrous oxide: a survey of Canadian anesthesiologists and residents  Journal Articles
• Impact of registration on clinical trials on infection risk in pediatric acute myeloid leukemia  Journal Articles
• Impact of the International Term Breech Trial on Clinical Practice and Concerns: A Survey of Centre Collaborators  Journal Articles
• Implantable Cardioverter Defibrillators in Cardiovascular Practice: Report of the Policy Conference of the North American Society of Pacing and Electrophysiology  Journal Articles
• Implementation of Timeline Reforms Speeds Initiation of National Cancer Institute-Sponsored Trials  Journal Articles
• Implication of Abnormal Human Trophoblast Karyotype for the Evidence‐Based Approach to the Understanding, Investigation, and Treatment of Recurrent Spontaneous Abortion  Journal Articles
• Implications of TeqCES: efficacy and safety of gatifloxacin in community-acquired pneumonia  Journal Articles
• Improving Cancer Outcomes Through International Collaboration in Academic Cancer Treatment Trials  Journal Articles
• Improving academic leadership and oversight in large industry-sponsored clinical trials: the ARO-CRO model  Journal Articles
• Improving outcome reporting in clinical trial reports and protocols: study protocol for the Instrument for reporting Planned Endpoints in Clinical Trials (InsPECT)  Journal Articles
• In adults with ATTR cardiac amyloidosis, patisiran reduced decline in functional capacity at 12 mo  Journal Articles
• In the Era of Systematic Reviews, Does the Size of an Individual Trial Still Matter?  Journal Articles
• In utero exposure to valproic acid and autism — A current review of clinical and animal studies  Journal Articles
• Incidence of childhood cancer in Canada during the COVID-19 pandemic  Journal Articles
• Incorporating Cultural Competence and Cultural Humility in Cardiovascular Clinical Trials to Increase Diversity Among Participants  Journal Articles
• Incorporating Utility-Based Quality-of-Life Assessment Measures in Clinical Trials  Journal Articles
• Increasing representation and diversity in cardiovascular clinical trial populations  Journal Articles
• Increasing research capacity in Canadian community hospitals: an intrinsic descriptive case study.  Journal Articles
• Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies  Journal Articles
• Independent measurement of functional capacity in rheumatoid arthritis.  Journal Articles
• Indications, Technique, and Complications of Balloon Tamponade for Variceal Gastrointestinal Bleeding  Journal Articles
• Influence of censoring on conclusions of trials for women with metastatic breast cancer  Journal Articles
• Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexia  Journal Articles
• Influenza Vaccination to Reduce Cardiovascular Morbidity and Mortality in Patients With COVID-19  Journal Articles
• Inhaled Corticosteroids for Asthma: Common Clinical Quandaries  Journal Articles
• Inhibition of the bronchial response to respiratory heat exchange by increasing doses of terbutaline sulphate.  Journal Articles
• Initial and long-term treatment of deep venous thrombosis: recent clinical trials and their impact on patient management  Journal Articles
• Insights and Perspectives on Dietary Modifications to Reduce the Risk of Cardiovascular Disease  Journal Articles
• Insights into the role of thrombin in the pathogenesis of recurrent ischaemia after acute coronary syndrome  Journal Articles
• Insulin Therapy in People Who Have Dysglycemia and Type 2 Diabetes Mellitus: Can It Offer Both Cardiovascular Protection and Beta-Cell Preservation?  Journal Articles
• Integrating Mortality and Morbidity Outcomes  Journal Articles
• Intellectual property considerations in the development and use of HRQL measures for clinical trial research  Journal Articles
• Intensive Initial Oral Anticoagulation and Shorter Heparin Treatment in Deep Vein Thrombosis  Journal Articles
• Intensive glucose control and macrovascular outcomes in type 2 diabetes  Journal Articles
• Intention to treat analysis in clinical trials when there are missing data  Journal Articles
• Intention-to-treat principle.  Journal Articles
• Interaction of St John's wort with conventional drugs: systematic review of clinical trials  Journal Articles
• Interactions of Warfarin with Drugs and Food  Journal Articles
• Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context  Journal Articles
• Internal consistency reliability is a poor predictor of responsiveness  Journal Articles
• International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma  Journal Articles
• International Gynecologic Cancer Society (IGCS 2012)  Journal Articles
• Interpretation and power of a pooled index.  Journal Articles
• Interpretation of the evidence for the efficacy and safety of statin therapy  Journal Articles
• Interpretation of treatment changes in 6-minute walk distance in patients with COPD  Journal Articles
• Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)  Journal Articles
• Interventions for waterpipe tobacco smoking prevention and cessation: a systematic review  Journal Articles
• Interventions that potentially limit myocardial infarct size: Overview of clinical trials  Journal Articles
• Interventions to Improve Medication Reconciliation in Primary Care  Journal Articles
• Interventions to improve adherence to antiretroviral therapy: a systematic review and network meta-analysis  Journal Articles
• Intramuscular cimetidine and ranitidine as prophylaxis against gastric aspiration syndrome - a randomized double-blind study  Journal Articles
• Intranasal nedocromil sodium in the treatment of ragweed-allergic rhinitis.  Journal Articles
• Intrapericardial Amiodarone for the Prevention of Postoperative Atrial Fibrillation  Journal Articles
• Intravenous Streptokinase for Acute Myocardial Infarction  Journal Articles
• Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: Overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials  Journal Articles
• Intravenous heparin for the prevention of stroke progression in acute partial stable stroke.  Journal Articles
• Intravenous magnesium in acute myocardial infarction. An effective, safe, simple, and inexpensive intervention.  Journal Articles
• Introduction  Journal Articles
• Investigating clinical heterogeneity in systematic reviews: a methodologic review of guidance in the literature  Journal Articles
• Investigator experiences with financial conflicts of interest in clinical trials  Journal Articles
• Investigator-initiated trials are more impartial  Journal Articles
• Investigator-led clinical research consortia: The Canadian Critical Care Trials Group  Journal Articles
• Irritable bowel syndrome and probiotics: from rationale to clinical use  Journal Articles
• Is Investigator Sex Associated With Female Underenrollment in Arrhythmia Trials?  Journal Articles
• Is Pain Ever “Normal”?  Journal Articles
• Is SABR Cost-Effective in Oligometastatic Cancer? An Economic Analysis of the SABR-COMET Randomized Trial  Conferences
• Is antithrombotic prophylaxis required in cancer patients with central venous catheters? Still an open question  Journal Articles
• Is it Time for Sex-Specific Guidelines for Cardiovascular Disease?  Journal Articles
• Is it possible to reduce cardiovascular risk with glucose-lowering approaches?  Journal Articles
• Is it safe to use a proton pump inhibitor with clopidogrel?  Journal Articles
• Is postoperative radiotherapy for radically resected NSCLC detrimental and therefore unnecessary?  Journal Articles
• Is routine indwelling catheterisation of the bladder for caesarean section necessary? A systematic review  Journal Articles
• Is there a place for the crossover design in infertility trials?  Journal Articles
• Is there a role for antioxidant vitamins in the prevention of cardiovascular diseases? An update on epidemiological and clinical trials data.  Journal Articles
• Is there a role for the novel oral anticoagulants in patients with an acute coronary syndrome? A review of the clinical trials  Journal Articles
• Is there any evidence for immunologically mediated or immunologically modifiable early pregnancy failure?  Journal Articles
• Is weight loss an effective treatment for hypertension? The evidence against  Journal Articles
• Issues in quality-of-life measurement in clinical trials  Journal Articles
• Joint WFH‐ISTH session: issues in clinical trial design  Journal Articles
• Journal requirement for data sharing statements in clinical trials: a cross-sectional study  Journal Articles
• Ketotifen and asthma.  Journal Articles
• Key design considerations for adaptive clinical trials: a primer for clinicians  Journal Articles
• LDP-02 (Millenium).  Journal Articles
• Landscape review of current HIV ‘kick and kill’ cure research - some kicking, not enough killing  Journal Articles
• Left Atrial Appendage Occlusion  Journal Articles
• Left Atrial Appendage Occlusion Does Not Eliminate the Need for Warfarin  Journal Articles
• Lessons from a systematic literature review of the effectiveness of recombinant factor VIIa in acquired haemophilia  Journal Articles
• Life-expectancy gains from pharmaceutical drugs: a critical appraisal of the literature  Journal Articles
• Limitation of myocardial infarction by early infusion of recombinant tissue-type plasminogen activator.  Journal Articles
• Long-Term Management of Venous Thromboembolism: Lessons from EINSTEIN CHOICE and Other Extension Trials  Journal Articles
• Long-Term Tolerability of the Bisphosphonates in Postmenopausal Osteoporosis  Journal Articles
• Long-term safety of biologics in dermatology  Journal Articles
• Long‐term Sequelae of Calf Vein Thrombosis Treated with Heparin or Low‐dose Streptokinase  Journal Articles
• Loss to follow-up in orthopaedic clinical trials: a systematic review  Journal Articles
• Low Levels of High-Density Lipoprotein Cholesterol and Increased Risk of Cardiovascular Events in Stable Ischemic Heart Disease Patients  Journal Articles
• Low molecular weight heparin: a critical analysis of clinical trials.  Journal Articles
• Low molecular weight heparins in the treatment of unstable angina.  Journal Articles
• Low molecular weight heparins: deep vein thrombosis prophylaxis in elective hip surgery and thrombotic stroke.  Journal Articles
• Low-Molecular-Weight Heparin or Oral Anticoagulation for Secondary Prevention of Deep Vein Thrombosis in Cancer Patients  Journal Articles
• Low-molecular-weight heparin in the treatment of pulmonary embolism.  Journal Articles
• Low-molecular-weight heparin thromboprophylaxis in medical-surgical critically ill patients: A systematic review  Journal Articles
• Lumbar disc disease.  Journal Articles
• Lung Clearance Index as an Outcome Measure for Clinical Trials in Young Children with Cystic Fibrosis. A Pilot Study Using Inhaled Hypertonic Saline  Journal Articles
• Lung cancer practice guidelines: lessons learned and issues addressed by the Ontario Lung Cancer Disease Site Group.  Journal Articles
• MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation  Journal Articles
• Magnesium in acute myocardial infarction  Journal Articles
• Mammographic screening: case–control studies  Journal Articles
• Management Issues Unique to Regulatory Trials  Journal Articles
• Management Of Venous Thromboembolism: Optimization By Clinical Trials  Journal Articles
• Management consensus guidance for the use of rivaroxaban – an oral, direct factor Xa inhibitor  Journal Articles
• Management of Glucocorticoid-Induced Osteoporosis  Journal Articles
• Management of Platelet-Directed Pharmacotherapy in Patients With Atherosclerotic Coronary Artery Disease Undergoing Elective Endoscopic Gastrointestinal Procedures  Journal Articles
• Management strategies in unstable coronary artery disease—Current problems and future directions  Journal Articles
• Managing neuropsychiatric disease with transcranial magnetic stimulation.  Journal Articles
• Mandatory contrast-enhanced venography to detect deep-vein thrombosis (DVT) in studies of DVT prophylaxis: upsides and downsides  Journal Articles
• Maternal mental health and integrated programs for mothers with substance abuse issues.  Journal Articles
• Maximizing the benefits of thrombolytic therapy for acute myocardial infarction.  Journal Articles
• Measurement of health status  Journal Articles
• Measurement of health-related quality of life in heart failure  Conferences
• Measurement of health-related quality of life in heart failure.  Journal Articles
• Measurements of Cardiac Output in Seriously Ill Patients Using a CO2 Rebreathing Method  Journal Articles
• Measuring Health-Related Quality of Life  Journal Articles
• Measuring disease-specific quality of life in clinical trials.  Journal Articles
• Measuring health status in chronic airflow limitation  Journal Articles
• Measuring health-related quality of life in rhinitis☆☆☆★  Journal Articles
• Measuring patient‐reported outcomes: moving from clinical trials into clinical practice  Journal Articles
• Measuring quality of life in clinical trials: a taxonomy and review.  Journal Articles
• Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A Consensus Statement of the American Diabetes Association and the European Association for the Study of Diabetes  Journal Articles
• Meeting report ESC Forum on Drug Eluting Stents, European Heart House, Nice, 27-28 September 2007  Journal Articles
• Meeting report: Considerations for trial design and endpoints in licensing therapeutic HPV16/18 vaccines to prevent cervical cancer  Journal Articles
• Megestrol acetate plus minidose diethylstilbestrol in the treatment of carcinoma of the prostate.  Journal Articles
• Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes  Journal Articles
• Melatonin agonists in primary insomnia and depression-associated insomnia: Are they superior to sedative-hypnotics?  Journal Articles
• Meta-analysis in medicine Where we are and where we want to go  Journal Articles
• Meta-analysis: A practical decision making tool for surgeons  Journal Articles
• Metabolomic adaptations and correlates of survival to immune checkpoint blockade  Journal Articles
• Method guidelines for Cochrane Musculoskeletal Group systematic reviews.  Journal Articles
• Methodologic challenges in the development of utility measures of health-related quality of life in rheumatoid arthritis  Journal Articles
• Methodologic discussions for using and interpreting composite endpoints are limited, but still identify major concerns  Journal Articles
• Methodologic issues in trials of antiemetics.  Journal Articles
• Methodologic pitfalls in assessing the efficacy of recombinant follicle-stimulating hormone versus human menopausal gonadotropin in assisted reproduction  Journal Articles
• Methodologic problems in clinical trials in heart failure  Journal Articles
• Methodological Issues in Systematic Reviews and Meta-Analyses of Observational Studies in Orthopaedic Research  Journal Articles
• Methodological and statistical issues of quality of life (QoL) and economic evaluation in cancer clinical trials: report of a workshop  Journal Articles
• Methodological issues in infertility research  Journal Articles
• Methods to convert continuous outcomes into odds ratios of treatment response and numbers needed to treat: meta-epidemiological study  Journal Articles
• Methotrexate/fluorouracil scheduling influences normal tissue toxicity but not antitumor effects in patients with squamous cell head and neck cancer: results from a randomized trial.  Journal Articles
• Metoprolol in acute myocardial infarction (MIAMI). A randomised placebo-controlled international trial  Journal Articles
• Miglustat as a therapeutic agent: prospects and caveats  Journal Articles
• Mineralocorticoid receptor antagonists and atrial fibrillation: a meta-analysis of clinical trials  Journal Articles
• Minimal Residual Disease Testing Infrastructure in Multiple Myeloma: Guidance for Clinical Trial and Routine Practice Use in Canada.  Journal Articles
• Minimal Risk Remains an Open Question  Journal Articles
• Missing data and the trouble with LOCF  Journal Articles
• Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis  Journal Articles
• Monitoring strontium ranelate therapy in patients with osteoporosis  Journal Articles
• Montelukast for the treatment of asthma in the adult population  Journal Articles
• More than just hype.  Journal Articles
• Mortality rates and risk factors for asymptomatic deep vein thrombosis in medical patients  Journal Articles
• Motivational factors for medical oncologists' participation in cancer treatment protocols.  Journal Articles
• Motor Unit Counting and the Caffeine Contracture Test in Malignant Hyperthermia  Journal Articles
• Moving forward in clinical research with master protocols  Journal Articles
• Moving promising research findings to the clinic: Methodological issues in the design and conduct of clinical trials of retinoids  Journal Articles
• Multicenter Collaboration in Observational Research: Improving Generalizability and Efficiency  Journal Articles
• Multiple uses of forest plots in presenting analysis results in health research: A Tutorial  Journal Articles
• National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group Report  Journal Articles
• National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. The 2014 Clinical Trial Design Working Group Report  Journal Articles
• Natural Health Product-Drug Interactions  Journal Articles
• Natural health product–HIV drug interactions: a systematic review  Journal Articles
• Need for Quality Improvement in Renal Systematic Reviews  Journal Articles
• Need for a new paediatric post thrombotic sequelae outcome measure for non-extremity thrombosis  Journal Articles
• Net clinical benefit of dabigatran vs. warfarin in venous thromboembolism: analyses from RE-COVER®, RE-COVER™ II, and RE-MEDY™  Journal Articles
• New Anticoagulant Therapy  Journal Articles
• New Anticoagulants  Journal Articles
• New Anticoagulants for Treatment of Venous Thromboembolism  Journal Articles
• New Antithrombotics  Journal Articles
• New anticoagulants  Conferences
• New anticoagulants in atrial fibrillation management  Conferences
• New anticoagulants.  Journal Articles
• New anticoagulants: an update.  Journal Articles
• New antithrombotic agents  Journal Articles
• New horizons on the landscape of AYA oncology  Journal Articles
• New oral anticoagulants for stroke prevention in atrial fibrillation: impact of study design, double counting and unexpected findings on interpretation of study results and conclusions  Journal Articles
• New oral anticoagulants: which one should my patient use?  Journal Articles
• New policies to address the global burden of childhood cancers  Journal Articles
• New strategies for clinical trials in patients with sepsis and septic shock  Journal Articles
• New therapeutic strategies to treat human cancers expressing mutant p53 proteins  Journal Articles
• Newer Antiepileptic Drugs in Bipolar Disorder  Journal Articles
• Newly Diagnosed Malignancy in Patients with VenousThromboembolism. Search or Wait and See?  Journal Articles
• No surgical innovation without evaluation: the IDEAL recommendations  Journal Articles
• Nocturnal Gastric Acid Secretion: Its Importance in the Pathophysiology and Rational Therapy of Duodenal Ulcer  Journal Articles
• Non-chemotherapeutic agents that potentiate chemotherapy efficacy  Journal Articles
• Non-vitamin K antagonist oral anticoagulants (NOACs): No longer new or novel  Journal Articles
• Non-vitamin-K oral anticoagulants (NOACs) for the prevention of secondary stroke  Journal Articles
• Noninferiority Margin Size and Acceptance of Trial Results: Contingent Valuation Survey of Clinician Preferences for Noninferior Mortality  Journal Articles
• Noninvasive Cardiac Monitoring for Detecting Paroxysmal Atrial Fibrillation or Flutter After Acute Ischemic Stroke  Journal Articles
• Norfloxacin: a new quinolone. Committee on Antimicrobial Agents, Canadian Infectious Disease Society.  Journal Articles
• Novel Oral Factor Xa and Thrombin Inhibitors in the Management of Thromboembolism  Journal Articles
• Novel antithrombotic strategies for treatment of venous thromboembolism  Journal Articles
• Novel antithrombotic therapies for the prevention of stroke in patients with atrial fibrillation.  Journal Articles
• Novel approaches and perspectives in allergen immunotherapy  Journal Articles
• Novel paediatric anticoagulants: a review of the current literature  Journal Articles
• Novel targeted therapies for eosinophilic disorders  Journal Articles
• OCTANE (Ontario-Wide Cancer Targeted Nucleic Acid Evaluation): A Platform for Intraprovincial, National, and International Clinical Data-Sharing  Journal Articles
• Obesity and renal cell carcinoma: epidemiology, underlying mechanisms and management considerations  Journal Articles
• Obtaining medically meaningful answers from an overview of randomized clinical trials  Journal Articles
• Off the beaten path: conducting ethical pragmatic trials with marginalized populations.  Journal Articles
• Omalizumab and the immune system: an overview of preclinical and clinical data  Journal Articles
• Once-Daily Therapy with Ceftriaxone Compared with Daily Multiple-Dose Therapy with Cefotaxime for Serious Bacterial Infections: A Randomized, Double-Blind Study  Journal Articles
• Oncolytic Viruses: Therapeutics With an Identity Crisis  Journal Articles
• Ontario Cancer Research Ethics Board: Lessons Learned From Developing a Multicenter Regional Institutional Review Board  Journal Articles
• Optimal reversal of vitamin K antagonists  Journal Articles
• Optimal sampling in derivation studies was associated with improved discrimination in external validation for heart failure prognostic models  Journal Articles
• Optimizing Prophylaxis of Venous Thromboembolism  Journal Articles
• Optimizing multiple Myeloma clinical trials: research direction, addressing limitations, and strategies for improvement.  Journal Articles
• Optimizing the Use of Abciximab and Intracoronary Stents in Patients with Acute ST Elevation Myocardial Infarction  Journal Articles
• Oral Anticoagulants  Journal Articles
• Oral Vitamin E Supplementation for the Prevention of Anemia in Premature Infants: A Controlled Trial  Journal Articles
• Oral anticoagulants in coronary heart disease (Section IV) Position paper of the ESC Working Group on Thrombosis – Task Force on Anticoagulants in Heart Disease  Journal Articles
• Oral anticoagulants in patients with coronary artery disease: an inexpensive and effective strategy  Journal Articles
• Oral anticoagulants. Mechanism of action, clinical effectiveness, and optimal therapeutic range.  Journal Articles
• Oral antiplatelet therapy.  Journal Articles
• Organ at Risk Dose Constraints in SABR: A Systematic Review of Active Clinical Trials  Journal Articles
• Osteoporosis clinical trials endpoints: candidate variables and clinimetric properties.  Journal Articles
• Outcome Measures in Rheumatology - Interventions for medication Adherence (OMERACT-Adherence) Core Domain Set for Trials of Interventions for Medication Adherence in Rheumatology: 5 Phase Study Protocol  Journal Articles
• Outcome measures for clinical research in sepsis: A report of the 2nd Cambridge Colloquium of the International Sepsis Forum  Journal Articles
• Outcomes Assessment in Fracture Healing Trials: A Primer  Journal Articles
• Outcomes for clinical trials involving adults with chronic kidney disease: a multinational Delphi survey involving patients, caregivers and health professionals  Journal Articles
• Outcomes of Passable and Non-passable Strictures in Clinical Trials of Crohn’s Disease: A Post-hoc Analysis  Journal Articles
• Overview of randomised trials of diuretics in pregnancy.  Journal Articles
• PET imaging for pediatric oncology: An assessment of the evidence  Journal Articles
• Pain during angiography: a randomized double-blind trial comparing ioxaglate and diatrizoate.  Journal Articles
• Panic prescribing has become omnipresent during the COVID-19 pandemic  Journal Articles
• Participation in HIV vaccine trials: listening to participant & community concerns.  Journal Articles
• Participation of community medical oncologists in clinical research trials.  Journal Articles
• Pathophysiologic and therapeutic importance of tissue ACE: a consensus report.  Journal Articles
• Patient Engagement and Shared Decision-Making  Journal Articles
• Patient Use of Smartphones to Communicate Subjective Data in Clinical Trials  Journal Articles
• Patient compliance and the conduct and interpretation of therapeutic trials  Journal Articles
• Patient enrollment and logistical problems top the list of difficulties in clinical research: a cross-sectional survey  Journal Articles
• Patient-important activity and participation outcomes in clinical trials involving children with chronic conditions  Journal Articles
• Patient-level compared with study-level meta-analyses demonstrate consistency of D-dimer as predictor of venous thromboembolic recurrences  Journal Articles
• Patients’ preferences for enrolment into critical-care trials  Journal Articles
• Pediatric Stroke Initiatives and Preliminary Studies: What Is Known and What Is Needed?  Conferences
• Pediatric oncology clinical trial participation where the geography is vast: Development of a clinical research system for tertiary and satellite centers in Ontario, Canada  Journal Articles
• Pemetrexed safety and dosing strategy  Journal Articles
• Peptide immunotherapy for allergic disease  Journal Articles
• Peptide immunotherapy for allergic diseases  Journal Articles
• Peptide-Mediated Immune Responses in Specific Immunotherapy  Journal Articles
• Peptide-based Vaccines in the Treatment of Specific Allergy  Journal Articles
• Peptide-based vaccination: where do we stand?  Journal Articles
• Periodic health examination, 1991 update: 6. Acetylsalicylic acid and the primary prevention of cardiovascular disease. Canadian Task Force on the Periodic Health Examination.  Journal Articles
• Perioperative Management of Patients Receiving Oral Anticoagulants  Journal Articles
• Perioperative Management of Patients Receiving Oral Anticoagulants  Journal Articles
• Perioperative anticoagulant management in patients with atrial fibrillation: practical implications of recent clinical trials  Journal Articles
• Pharmacologic insights into the future of trastuzumab.  Conferences
• Pharmacological Actions of Sulodexide  Journal Articles
• Pharmacological Treatment of Ankylosing Spondylitis  Journal Articles
• Pharmacological Treatment of Hypertension in Pregnancy  Journal Articles
• Phase 1 Trial Design: Is 3 + 3 the Best?  Journal Articles
• Phase II study of Triapine® in patients with metastatic renal cell carcinoma: a trial of the National Cancer Institute of Canada Clinical Trials Group (NCIC IND.161)  Journal Articles
• Phase II trial evaluating continuous infusion of etoposide, cisplatin, and hexamethylmelamine in extensive-disease small cell carcinoma of the lung.  Journal Articles
• Pitfalls in the design and analysis of efficacy trials in subfertility: Associate editor's commentary: on the article 'Common statistical errors in the design and analysis of subfertility trials' by A.Vail and E.Gardner.  Journal Articles
• Placebo use and unblinding in COVID-19 vaccine trials: recommendations of a WHO Expert Working Group  Journal Articles
• Platelet Utilization: A Canadian Blood Services Research and Development Symposium  Journal Articles
• Platelet count or bleeding as the outcome in ITP trials?  Journal Articles
• Platelet inhibitors in the treatment of thrombosis.  Journal Articles
• Platelet-Inhibiting Drugs in the Prevention of Clinical Thrombotic Disease  Journal Articles
• Platelet-Inhibiting Drugs in the Prevention of Clinical Thrombotic Disease  Journal Articles
• Platelet-Inhibiting Drugs in the Prevention of Clinical Thrombotic Disease  Journal Articles
• Podophyllotoxin derivative VP 16-213  Journal Articles
• Point/counterpoint: early-stage Hodgkin lymphoma and the role of radiation therapy.  Journal Articles
• Polypill Variants (Quarter Pill Trials)  Journal Articles
• Pooled outcome measures in arthritis: the pros and cons.  Journal Articles
• Poor Cognitive Function and Risk of Severe Hypoglycemia in Type 2 Diabetes  Journal Articles
• Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors  Journal Articles
• Potential for altering the natural history of congestive heart failure: Need for large clinical trials  Journal Articles
• Potential of new anticoagulants in patients with cancer  Journal Articles
• Power function arguments in support of an alternative approach for analyzing management trials  Journal Articles
• Practical Application of¹²⁵I-Fibrinogen Leg Scanning  Journal Articles
• Practical Model-Based Dose Finding in Early-Phase Clinical Trials  Journal Articles
• Practices and Attitudes of Swiss Stakeholders Regarding Investigator-Initiated Clinical Trial Funding Acquisition and Cost Management  Journal Articles
• Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder  Journal Articles
• Predictors of dropout from cardiac exercise rehabilitation  Journal Articles
• Pregnancy and COVID‐19: pharmacologic considerations  Journal Articles
• Pregnant and lactating women should be included in clinical trials for cardiovascular disease  Journal Articles
• Preoperative or Postoperative Therapy for Stage II or III Rectal Cancer: An Updated Practice Guideline  Journal Articles
• Presentation approaches for enhancing interpretability of patient-reported outcomes (PROs) in meta-analysis: a protocol for a systematic survey of Cochrane reviews  Journal Articles
• Prevalence of endoscopic improvement and remission according to patient‐reported outcomes in ulcerative colitis  Journal Articles
• Preventing Cardioembolic Stroke in Atrial Fibrillation with Dabigatran  Journal Articles
• Preventing Venous Thromboembolism in Critically Ill Patients  Journal Articles
• Prevention and Treatment of Hormone-Associated Venous Thromboembolism: A Patient Management Approach  Journal Articles
• Prevention of Thrombotic Disorders in Cancer Patients Undergoing Chemotherapy  Journal Articles
• Prevention of Venous Thromboembolism  Journal Articles
• Prevention of Venous Thrombosis After Elective Hip Surgery  Journal Articles
• Prevention of coronary heart disease with aspirin and clopidogrel: efficacy, safety, costs and cost-effectiveness  Journal Articles
• Prevention of deep vein thrombosis in potential neurosurgical patients. A randomized trial comparing graduated compression stockings alone or graduated compression stockings plus intermittent pneumatic compression with control  Journal Articles
• Prevention of venous thromboembolism in medically ill patients: a clinical update  Journal Articles
• Primary Prevention of Child Physical Abuse and Neglect: A Critical Review. Part I  Journal Articles
• Primary Prevention of Child Sexual Abuse: A Critical Review. Part II  Journal Articles
• Primary angioplasty for ST-segment elevation myocardial infarction: ready for prime time?  Journal Articles
• Principles of Designing an Orthopaedic Case-Control Study  Journal Articles
• Pro: “Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation”  Journal Articles
• Probabilistic Analysis of Cost-Effectiveness Models: Choosing between Treatment Strategies for Gastroesophageal Reflux Disease  Journal Articles
• Probabilistic Analysis of Cost-Effectiveness Models: Choosing between Treatment Strategies for Gastroesophageal Reflux Disease  Journal Articles
• Proceedings of a workshop  Journal Articles
• Proceedings: Failure of aspirin and dipyridamole to influence the incidence of leg scan detected venous thrombosis after elective hip surgery.  Journal Articles
• Process evaluation in the field: global learnings from seven implementation research hypertension projects in low-and middle-income countries  Journal Articles
• Progress review: the relationship between dose of aspirin, side-effects and antithrombotic effectiveness.  Journal Articles
• Prophylaxis of upper gastrointestinal bleeding in intensive care units  Journal Articles
• Pros and Cons of Composite Endpoints in Anesthesia Trials  Journal Articles
• Prospective randomized trial of one-hour sequential versus simultaneous methotrexate plus 5-fluorouracil in advanced and recurrent squamous cell head and neck cancer.  Journal Articles
• Prospects of the Clinical Utilization of Melatonin  Journal Articles
• Prostate cancer radiotherapy 2002: the way forward.  Journal Articles
• Protocol Understanding and Anxiety in Perioperative Clinical Trial Patients Approached for Consent on the Day of Surgery  Journal Articles
• Protocol‐based treatment for children with cancer in low income countries in Latin America: A report on the recent meetings of the Monza International School of Pediatric Hematology/Oncology (MISPHO)—Part II  Journal Articles
• Proton pump inhibitors in acute non‐variceal upper gastrointestinal bleeding  Journal Articles
• Psoriasis of the nail: Anatomy, pathology, clinical presentation, and a review of the literature on therapy  Journal Articles
• Putting More Weight on Obesity Trials in Heart Failure  Journal Articles
• Q&A: Antibiotic resistance: what more do we know and what more can we do?  Journal Articles
• Quality of life in stage II breast cancer: an instrument for clinical trials.  Journal Articles
• Quality of life questionnaires: Does statistically significant = clinically important?  Journal Articles
• Quality-of-Life Assessment: Patient Compliance With Questionaire Completion  Journal Articles
• Qualiveen: A Urinary Disorder−Specific Instrument for Use in Clinical Trials in Multiple Sclerosis  Journal Articles
• RANDOMISED CLINICAL TRIAL OF STRATEGIES FOR IMPROVING MEDICATION COMPLIANCE IN PRIMARY HYPERTENSION  Journal Articles
• RANDOMISED COMPARISON OF TWO INTENSITIES OF ORAL ANTICOAGULANT THERAPY AFTER TISSUE HEART VALVE REPLACEMENT  Journal Articles
• RANITIDINE 150 mg TWICE DAILY VS 300 mg NIGHTLY IN TREATMENT OF DUODENAL ULCERS  Journal Articles
• ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions  Journal Articles
• Radiation Therapy Oncology Group. Research Plan 2002-2006. Gynecology Cancer Working Group.  Journal Articles
• Radiation in early-stage Hodgkin lymphoma.  Journal Articles
• Radiological changes in rheumatoid arthritis: measurement of area of juxta-articular bone as outcome event in clinical therapeutic trials of antirheumatic drugs.  Journal Articles
• Randomisation to protect against selection bias in healthcare trials  Journal Articles
• Randomised comparison of early versus late induction of labour in post-term pregnancy  Journal Articles
• Randomized Control Trials and the EC-IC Arterial Anastomosis Procedure  Journal Articles
• Randomized clinical trial of an oscillating air mattress in preterm infants: Effect on apnea, growth, and development  Journal Articles
• Randomized clinical trial of supportive follow-up for cigarette smokers in a family practice.  Journal Articles
• Randomized trials in orthopaedics  Journal Articles
• Real-Life Research  Journal Articles
• Reasons for the loss of sensitivity and specificity of methodologic MeSH terms and textwords in MEDLINE.  Journal Articles
• Reassessing Quality-of-Life Instruments in the Evaluation of New Drugs  Journal Articles
• Reassessing the Th2 cytokine basis of asthma  Journal Articles
• Recent clinical trials in the treatment of venous thromboembolism and unstable angina with low molecular weight heparins  Journal Articles
• Recommendations for Clinical Trials in ICH  Journal Articles
• Recommendations for a core outcome measurement set for clinical trials in whiplash associated disorders  Journal Articles
• Recommendations for a first Core Outcome Measurement set for complex regional PAin syndrome Clinical sTudies (COMPACT)  Journal Articles
• Recommendations for national and local regulatory authorities concerning research in genetic markers of disease  Journal Articles
• Recommendations for standardized risk factor definitions in pediatric hospital‐acquired venous thromboembolism to inform future prevention trials: communication from the SSC of the ISTH  Journal Articles
• Recommendations for the implementation of platelet autoantibody testing in clinical trials of immune thrombocytopenia  Journal Articles
• Recommended Patient-Reported Core Set of Symptoms to Measure in Prostate Cancer Treatment Trials  Journal Articles
• Recovery room oxygenation: A comparison of nasal catheters and 40 per cent oxygen masks  Journal Articles
• Recruitment for an efficacy study in chemoprevention—The concerned smoker study  Journal Articles
• Recurrent events in meta-analysis of multiple clinical trials.  Journal Articles
• Recurrent spontaneous early pregnancy loss and low dose aspirin.  Journal Articles
• Reduced joint counts in rheumatoid arthritis clinical trials  Journal Articles
• Reducing the risk of urgent revascularization for unstable angina: A randomized clinical trial  Journal Articles
• Reduction in Fatal Pulmonary Embolism and Venous Thrombosis by Perioperative Administration of Subcutaneous Heparin  Journal Articles
• Reduction of ventricular arrhythmias by early intravenous atenolol in suspected acute myocardial infarction.  Journal Articles
• Regularly inhaled β-agonists in stable asthma  Journal Articles
• Relation of exercise to the recurrence rate of myocardial infarction in men  Journal Articles
• Relationship Between A1C and Fasting Plasma Glucose in Dysglycemia or Type 2 Diabetes  Journal Articles
• Reliability of Trial Information Across Registries for Trials With Multiple Registrations  Journal Articles
• Replication of machine learning methods to predict treatment outcome with antidepressant medications in patients with major depressive disorder from STAR*D and CAN-BIND-1  Journal Articles
• Report of the Conference on Low Blood Cholesterol: Mortality Associations.  Journal Articles
• Reporting Guidelines for Imaging Research  Journal Articles
• Reporting bias in breast reconstruction clinical trials: Which and when clinical trials get published  Journal Articles
• Reporting of IMMPACT-recommended core outcome domains among trials assessing opioids for chronic non-cancer pain  Journal Articles
• Reporting of health equity considerations in vaccine trials for COVID-19: author’s reply  Journal Articles
• Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review  Journal Articles
• Researching the Cost of Research  Journal Articles
• Resolving Controversies in Hip Fracture Care: The Need for Large Collaborative Trials in Hip Fractures  Journal Articles
• Respiratory Muscle Training in Chronic Airflow Limitation: A Meta-Analysis  Journal Articles
• Response of borderline and schizotypal patients to small doses of thiothixene and haloperidol  Journal Articles
• Response to commentaries on the Canadian Network for Mood and Anxiety Treatments/International Society for Bipolar Disorders 2013 updated Bipolar Disorder Guidelines  Journal Articles
• Responsiveness and validity in health status measurement: A clarification  Journal Articles
• Resting heart rate: A modifiable prognostic indicator of cardiovascular risk and outcomes?  Journal Articles
• Review of the Emerging Treatment of Clostridium difficile Infection with Fecal Microbiota Transplantation and Insights into Future Challenges  Journal Articles
• Rhinitis management: the patient’s perspective  Journal Articles
• Rigorous Evaluation  Journal Articles
• Riociguat for the treatment of pulmonary hypertension  Journal Articles
• Risk factors for nausea and vomiting after general anaesthesia.  Journal Articles
• Risk of heparin-induced thrombocytopenia in patients receiving thromboprophylaxis  Journal Articles
• Risk-Benefit Assessment of Antiarrhythmic Drugs  Journal Articles
• Rituximab in lymphoma: A systematic review and consensus practice guideline from Cancer Care Ontario  Journal Articles
• Role of the renin-angiotensin-aldosterone system in atrial fibrillation and cardiac remodeling.  Journal Articles
• SINGLE-PATIENT RANDOMISED CLINICAL TRIAL Use in Determining Optimum Treatment for Patient with Inflammation of Kock Continent Ileostomy Reservoir  Journal Articles
• SMART therapy  Journal Articles
• SPECIAL ISSUE: DESIGNING IMPLANT TRIALSGUEST EDITOR: MOHIT BHANDARIPreface: Designing Implant Trials in 2010: A Recipe for Success  Journal Articles
• SPRINT trial and blood pressure treatment. Dr. Gordon Guyatt in an interview with Dr. Roman Jaeschke  Journal Articles
• SUBCUTANEOUS IGF-1 IS NOT BENEFICIAL IN 2-YEAR ALS TRIAL  Journal Articles
• SUBJECTIVE ASSESSMENT OF THE EFFECT OF CATARACT-SURGERY AND A REVIEW OF LONG-TERM AIMS  Journal Articles
• Safe use of long-acting β-agonists: what have we learnt?  Journal Articles
• Safety and efficacy of gatifloxacin in community-acquired pneumonia: rationale for the Tequin Clinical Experience Study (TeqCES)  Conferences
• Sample Size and Power in Psychiatric Research^*  Journal Articles
• Sample Size in the Planning and Interpretation of Clinical Trials  Journal Articles
• Sample size and power considerations in network meta-analysis  Journal Articles
• Sample size and power issues in estimating incremental cost-effectiveness ratios from clinical trials data  Journal Articles
• Sample size calculations: should the emperor's clothes be off the peg or made to measure?  Journal Articles
• Sample size for randomized trials in stroke prevention. How many patients do we need?  Journal Articles
• Scientific Requirements for Diagnostic Tests in Gastroenterology  Journal Articles
• Sclerostin: More than a bone formation brake  Journal Articles
• Scoping review and characteristics of publicly available checklists for assessing clinical trial feasibility  Journal Articles
• Screening of ARDS patients using standardized ventilator settings: influence on enrollment in a clinical trial  Journal Articles
• Searching MEDLINE for Randomized Clinical Trials Involving Care of the Newborn  Journal Articles
• Second-line chemotherapy of stage III-IV ovarian carcinoma: a randomized comparison of melphalan to melphalan and hexamethylmelamine in patients with persistent disease after doxorubicin and cisplatin.  Journal Articles
• Selected Principles of the Measurement and Setting of Priorities of Death, Disability, and Suffering in Clinical Trials  Journal Articles
• Selection and combination of outcome measures.  Journal Articles
• Selection and results of antiplatelet therapy in the prevention of stroke and myocardial infarction  Journal Articles
• Selective factor Xa inhibition for thromboprophylaxis  Journal Articles
• Selenium and Lung Cancer: A Systematic Review and Meta Analysis  Journal Articles
• Self-recording of blood pressure in the management of hypertension.  Journal Articles
• Sensitive Clinical Queries retrieved relevant systematic reviews as well as primary studies: an analytic survey  Journal Articles
• Sentinel Lymph Node Biopsy in Breast Cancer: Canadian Practice Patterns  Conferences
• Serious adverse events in academic critical care research  Journal Articles
• Serotonin Agents in the Treatment of Acquired Brain Injury  Journal Articles
• Setting a standard for venous thromboembolism prophylaxis  Journal Articles
• Sex and Gender Subgroup Analyses of Randomized Trials  Journal Articles
• Sex and gender-based analysis and diversity metric reporting in acute care trials published in high-impact journals: a systematic review  Journal Articles
• Sharing interim trial results by the Data Safety Monitoring Board with those responsible for the trial’s conduct and progress: a narrative review  Journal Articles
• Should Clinical Trials Be Terminated Early?  Journal Articles
• Should Patients With Ischemic Stroke or Transient Ischemic Attack With Atrial Fibrillation and Microbleeds Be Anticoagulated?  Journal Articles
• Should patients with stable coronary artery disease be treated with ACE inhibitor therapy?  Journal Articles
• Should recommendations about starting inhaled corticosteroid treatment for mild asthma be based on symptom frequency: a post-hoc efficacy analysis of the START study  Journal Articles
• Simulation Modeling of Cancer Clinical Trials: Application to Omitting Radiotherapy in Low-risk Breast Cancer  Journal Articles
• Single pivotal trials with few corroborating characteristics were used for FDA approval of cancer therapies  Journal Articles
• Small Subcutaneous Doses of Heparin in Prevention of Venous Thrombosis  Journal Articles
• Smartphone Application for Pre-Hospital ECG Transmission in STEMI Activation: Protocol for a Mixed Methods Study (Preprint)  Journal Articles
• Smoking cessation in primary care. A randomized controlled trial of nicotine-bearing chewing gum.  Journal Articles
• Society of Interventional Radiology Research Reporting Standards for Prostatic Artery Embolization  Journal Articles
• Sodium cromoglycate in ragweed-allergic conjunctivitis  Journal Articles
• Sources of bias in diagnostic accuracy studies and the diagnostic process  Journal Articles
• Standard 5: Selection, Measurement, and Reporting of Outcomes in Clinical Trials in Children  Journal Articles
• Standard Operating Procedures: The Devil Is in the Details  Journal Articles
• Standardized Bleeding Definitions for Cardiovascular Clinical Trials  Journal Articles
• Standardized audiotape versus recorded consultation to enhance informed consent to a clinical trial in breast oncology  Journal Articles
• Starting prophylaxis for venous thromboembolism postoperatively  Journal Articles
• Statistical Significance in Trauma Research: Too Unstable to Trust?  Journal Articles
• Statistical issues in the use of dynamic allocation methods for balancing baseline covariates  Journal Articles
• Statistics Commentary Series  Journal Articles
• Statistics Commentary Series  Journal Articles
• Stopping Trials for Benefit Can (Sometimes) Benefit Patients  Journal Articles
• Strategies for patient recruitment into clinical trials  Journal Articles
• Strategies to enhance patient recruitment and retention in research involving patients with a first episode of mental illness  Journal Articles
• Stratification according to HGG-IMMUNO RPA model predicts outcome in a large group of patients with relapsed malignant glioma treated by adjuvant postoperative dendritic cell vaccination  Journal Articles
• Stress Ulcer Prophylaxis: Gastrointestinal Bleeding and Nosocomial Pneumonia Best Evidence Synthesis  Journal Articles
• Stroke and Cardiovascular Diseases: The Need for a Global Approach for Prevention and Drug Development  Journal Articles
• Student-designed clinical trials: evaluating self-directed learning in pharmacology  Journal Articles
• Studies on the frequency of heparin-associated thrombocytopenia  Journal Articles
• Studies on the medical treatment of deep vein thrombosis.  Journal Articles
• Study design attributes influenced patients' willingness to participate in clinical research: a randomized vignette-based study  Journal Articles
• Subjective assessment of the effect of cataract surgery and a review of long term aims  Journal Articles
• Sub‐lingual Immunotherapy: World Allergy Organization Position Paper 2009  Journal Articles
• Successors to heparin: new antithrombotic agents.  Journal Articles
• Sucralfate: The Bangkok review  Journal Articles
• Summaries of findings, descriptions of interventions, and information about adverse effects would make reviews more informative  Journal Articles
• Superiority of Alternating Non-Cross-Resistant Chemotherapy in Extensive Small Cell Lung Cancer  Journal Articles
• Surgical management of malignant pleural mesothelioma: a systematic review and evidence summary  Journal Articles
• Surrogate Markers in Clinical Studies: Problems Solved or Created?  Journal Articles
• Survey of professional views on sharing interim results by the Data Safety Monitoring Board (DSMB): what to share, with whom and why  Journal Articles
• Survival results from a phase III study of simultaneous versus 1‐hour sequential methotrexate—5‐fluorouracil chemotherapy in head and neck cancer  Journal Articles
• Symposium 4: Hot topics in parenteral nutrition A review of the use of glutamine supplementation in the nutritional support of patients undergoing bone-marrow transplantation and traditional cancer therapy  Journal Articles
• Symptom evaluation in reflux disease: workshop background, processes, terminology, recommendations, and discussion outputs  Journal Articles
• Symptom-Based Outcome Measures for Dyspepsia and GERD Trials: A Systematic Review  Journal Articles
• Systematic Literature Review and Meta-Analysis  Journal Articles
• Systematic Overview of Warfarin and Its Drug and Food Interactions  Journal Articles
• Systematic Reviews of Nonrandomized Clinical Studies in the Orthopaedic Literature  Journal Articles
• Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine initiative: clinical indicators  Journal Articles
• Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes  Journal Articles
• Systematic review and meta-analysis methodology  Journal Articles
• Systematic review of basket trials, umbrella trials, and platform trials: a landscape analysis of master protocols  Journal Articles
• Systematic review: conservative treatments for secondary lymphedema  Journal Articles
• Systematic review: persistence and severity in gastro‐oesophageal reflux disease  Journal Articles
• Systematic reviewers commonly contact study authors but do so with limited rigor  Journal Articles
• Systematic scoping review identifies heterogeneity in outcomes measured in adolescent depression clinical trials  Journal Articles
• Systemic Therapy for Previously Untreated Advanced BRAF -Mutated Melanoma: Navigating a Shifting Landscape  Journal Articles
• TAMOXIFEN PROPHYLAXIS  Journal Articles
• THE EFFECTS OF A THREE-MONTH EXERCISE PROGRAMME ON NEUROPSYCHOLOGICAL FUNCTION IN ELDERLY INSTITUTIONALIZED WOMEN: A RANDOMIZED CONTROLLED TRIAL  Journal Articles
• THE FEASIBILITY OF MATCHING AND QUOTA SAMPLING IN EPIDEMIOLOGIC STUDIES  Journal Articles
• THE RELATIONSHIP BETWEEN DOSE OF ASPIRIN, SIDE-EFFECTS AND ANTITHROMBOTIC EFFECTIVENESS  Journal Articles
• THROMBOLYTIC THERAPY FOR VENOUS THROMBOEMBOLISM  Journal Articles
• THROMBOLYTIC THERAPY IN NEUROINTENSIVE CARE  Journal Articles
• TIPS to decide whether to prescribe aspirin for the primary prevention of cardiovascular events in chronic kidney disease  Journal Articles
• Tamoxifen May Be an Effective Adjuvant Treatment for BRCA1-Related Breast Cancer Irrespective of Estrogen Receptor Status  Journal Articles
• Targeting Genes for Treatment in Idiopathic Pulmonary Fibrosis: Challenges and Opportunities, Promises and Pitfalls  Journal Articles
• Targeting apoptosis: preclinical and early clinical experience with mapatumumab, an agonist monoclonal antibody targeting TRAIL-R1  Journal Articles
• Targeting the epidermal growth factor receptor in non-small-cell lung cancer: Who, which, when, and how?  Journal Articles
• Technical review: High-intensity focused ultrasound for prostate cancer.  Journal Articles
• Temporal Trends and Clinical Trial Characteristics Associated With the Inclusion of Women in Heart Failure Trial Steering Committees: A Systematic Review  Journal Articles
• Testing for heterogeneity among the components of a binary composite outcome in a clinical trial  Journal Articles
• Tezepelumab in patients with allergic and eosinophilic asthma  Journal Articles
• The 1st WFH Gene Therapy Round Table: Understanding the landscape and challenges of gene therapy for haemophilia around the world  Journal Articles
• The 2 “Es” of Research: Efficacy and Effectiveness Trials  Journal Articles
• The 2014 Canadian Cardiovascular Society Heart Failure Management Guidelines Focus Update: Anemia, Biomarkers, and Recent Therapeutic Trial Implications  Journal Articles
• The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. The Committee on Outcome Measures in Rheumatoid Arthritis Clinical Trials.  Journal Articles
• The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease  Journal Articles
• The CONSORT Patient-Reported Outcome (PRO) extension: implications for clinical trials and practice  Journal Articles
• The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Design, organization, and baseline results.  Journal Articles
• The Case of the Missing Data: Methods of Dealing with Dropouts and other Research Vagaries  Journal Articles
• The Clinical Utility of Kidney Injury Molecule 1 in the Prediction, Diagnosis and Prognosis of Acute Kidney Injury: A Systematic Review  Journal Articles
• The Contents and Readability of Informed Consent Forms for Oncology Clinical Trials  Journal Articles
• The Current Status of Platelet Suppressive Drugs in the Treatment of Thrombosis  Journal Articles
• The Data and Safety Monitoring Committee: Some final thoughts  Journal Articles
• The Duration of Oral Anticoagulation after Deep Vein Thrombosis  Journal Articles
• The Effect of Positive Pressure Airway Support on Mortality and the Need for Intubation in Cardiogenic Pulmonary Edema  Journal Articles
• The Effect of Vitamin D Supplementation on Prostate Cancer: A Systematic Review and Meta-Analysis of Clinical Trials  Journal Articles
• The Effects of Fructose Intake on Serum Uric Acid Vary among Controlled Dietary Trials  Journal Articles
• The Effects of Methylphenidate on the Mother-Child Interactions of Hyperactive Children  Journal Articles
• The Efficacy of Leukodepletion to Improve Platelet Transfusion Response: A Critical Appraisal of Clinical Studies  Journal Articles
• The FDA-mandated trial of safety of long-acting beta-agonists in asthma: finality or futility?  Journal Articles
• The Facilitatory Effects of Intravenous Dexmedetomidine on the Duration of Spinal Anesthesia  Journal Articles
• The Guideline-Policy Gap in Direct-Acting Oral Anticoagulants Usage in Atrial Fibrillation: Evidence, Practice, and Public Policy Considerations  Journal Articles
• The Head and Neck Radiotherapy Questionnaire: a morbidity/quality-of-life instrument for clinical trials of radiation therapy in locally advanced head and neck cancer.  Journal Articles
• The Impact of Evidence in Surgery of the Musculoskeletal System  Journal Articles
• The Importance of Clinical Trials in Preterm Labor  Journal Articles
• The Ineffectiveness of Immunosuppressive Therapy in Lymphocytic Myocarditis: An Overview  Journal Articles
• The Influence of Large Clinical Trials in Orthopedic Trauma  Journal Articles
• The Labor and Delivery Satisfaction Index: The Development and Evaluation of a Soft Outcome Measure  Journal Articles
• The MACTAR Patient Preference Disability Questionnaire--an individualized functional priority approach for assessing improvement in physical disability in clinical trials in rheumatoid arthritis.  Journal Articles
• The Management of Hypertension in the Overweight and Obese Patient  Journal Articles
• The McMaster Health Index Questionnaire as a measure of quality of life for patients with rheumatoid disease.  Journal Articles
• The Metrics of Clinical Trials  Journal Articles
• The Moral Imperative to Include Pregnant Women in Clinical Trials of Interventions for COVID-19  Journal Articles
• The Non-Vitamin K Antagonist Oral Anticoagulants in Heart Disease: Section V—Special Situations  Journal Articles
• The Optimal Timing of Primary Prevention Implantable Cardioverter-Defibrillator Referral in the Rapidly Changing Medical Landscape  Journal Articles
• The REthinking Clinical Trials Program Retreat 2023: Creating Partnerships to Optimize Quality Cancer Care  Journal Articles
• The ROMA trial: 7 years of trial activities and the development of the ROMA trial network  Journal Articles
• The Role of Angiotensin II Receptor Blockers in the Treatment of Heart Failure Patients  Journal Articles
• The SPRINT and the HOPE-3 Trial in the Context of Other Blood Pressure–Lowering Trials  Journal Articles
• The Second Heart Program—A multidisciplinary team supporting people who inject drugs with infective endocarditis: Protocol of a feasibility study  Journal Articles
• The Treatment of Heart Failure  Journal Articles
• The Urgent Need for Clinical Research Reform to Permit Faster, Less Expensive Access to New Therapies for Lethal Diseases  Journal Articles
• The Value of Value of Information  Journal Articles
• The YouTube Cure  Journal Articles
• The alternating-sequence design (or multiple-period crossover) trial for evaluating treatment efficacy in infertility  Journal Articles
• The architecture of diagnostic research: From bench to bedside-research guidelines using liver stiffness as an example  Journal Articles
• The association of previously reported polymorphisms for microvascular complications in a meta-analysis of diabetic retinopathy  Journal Articles
• The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?  Journal Articles
• The challenges of measuring bleeding outcomes in clinical trials of platelet transfusions  Journal Articles
• The complex task of measuring intestinal permeability in basic and clinical science  Journal Articles
• The credibility of subgroup analyses reported in stroke trials is low: A systematic review  Journal Articles
• The difference between study recommendations, stated policy, and actual practice in a clinical trial  Journal Articles
• The effect of dose of thoracic irradiation on recurrence in patients with limited stage small cell lung cancer. Initial results of a canadian multicenter randomized trial  Journal Articles
• The effect of perindopril on cardiovascular morbidity and mortality in patients with diabetes in the EUROPA study: results from the PERSUADE substudy  Journal Articles
• The effect of terbutaline in exercise-induced asthma.  Journal Articles
• The effects of excluding treatments from network meta-analyses: survey  Journal Articles
• The efficacy of proton pump inhibitors in nonulcer dyspepsia: A systematic review and economic analysis  Journal Articles
• The emerging role of low-molecular-weight heparin in cardiovascular medicine  Journal Articles
• The entry ECG in the early diagnosis and prognostic stratification of patients with suspected acute myocardial infarction  Journal Articles
• The evidence for tamoxifen and chemotherapy as treatment for metastatic melanoma  Journal Articles
• The evolution of theEuropean Respiratory Journal: volume 2  Journal Articles
• The fragility of trial results involves more than statistical significance alone  Journal Articles
• The future of translational research on alcohol use disorder  Journal Articles
• The gastrointestinal tolerability and safety of oral bisphosphonates  Journal Articles
• The granting of emergency use designation to COVID-19 candidate vaccines: implications for COVID-19 vaccine trials  Journal Articles
• The history and development of N-of-1 trials  Journal Articles
• The impact of ustekinumab on extraintestinal manifestations of Crohn's disease: A post hoc analysis of the UNITI studies  Journal Articles
• The importance of adjusting for potential confounders in Bayesian hierarchical models synthesising evidence from randomised and non-randomised studies: an application comparing treatments for abdominal aortic aneurysms  Journal Articles
• The international EC/IC bypass study.  Journal Articles
• The likelihood ratio versus the p value in meta-analysis: Where is the evidence?  Journal Articles
• The management of congestive heart failure  Journal Articles
• The management of patients who require temporary reversal of vitamin K antagonists for surgery: a practical guide for clinicians  Journal Articles
• The neuroscience of recovery and rehabilitation: What have we learned from animal research?  Journal Articles
• The new heparins  Journal Articles
• The new oral anticoagulants  Journal Articles
• The onerous task of comparing treatments in inhibitor patients  Journal Articles
• The physics of photodynamic therapy  Journal Articles
• The potential of peptide immunotherapy in allergy and asthma  Journal Articles
• The promise of and problems with evidence‐based medicine for paediatric asthma management  Journal Articles
• The promise of electronic data capture in respiratory medicine  Journal Articles
• The protective effect of inhaled chlorpheniramine and atropine on bronchoconstriction stimulated by airway cooling.  Journal Articles
• The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: A simulation study  Journal Articles
• The roadmap to integrate diversity, equity, and inclusion in hematology clinical trials: an American Society of Hematology initiative.  Journal Articles
• The role of chemotherapy in invasive thymoma: a review of the literature and considerations for future clinical trials  Journal Articles
• The role of comparative effectiveness research in transfusion medicine clinical trials: proceedings of a National Heart, Lung, and Blood Institute workshop  Journal Articles
• The role of luteal phase support in infertility treatment: a meta-analysis of randomized trials  Journal Articles
• The role of palliative radiotherapy for brain metastases.  Journal Articles
• The role of radiation therapy in malignant pleural mesothelioma: A systematic review  Journal Articles
• The role of recombinant factor VIIa in on-pump cardiac surgery: Proceedings of the Canadian Consensus Conference  Journal Articles
• The role of sulfinpyrazone in the prevention of arterio-venous shunt thrombosis.  Journal Articles
• The safety of fondaparinux for the prevention and treatment of venous thromboembolism  Journal Articles
• The sirens are singing: The perils of trusting trials stopped early and subgroup analyses*  Journal Articles
• The technical report on sodium intake and cardiovascular disease in low- and middle-income countries by the joint working group of the World Heart Federation, the European Society of Hypertension and the European Public Health Association  Journal Articles
• The therapeutic potential of angiotensin II receptor blockers in the treatment of heart failure  Journal Articles
• The top 4 advances in antithrombotic care in the last year  Journal Articles
• The treatment of gastric ulcer with antisecretory drugs  Journal Articles
• The undue influence of significant p-values on the perceived importance of study results  Journal Articles
• The unfulfilled promise of efficacy trials in HIV/hepatitis C co-infected patients  Journal Articles
• The use and abuse of surrogate endpoints in clinical research in transfusion medicine  Journal Articles
• The use of VP-16 plus cisplatin during induction chemotherapy for small-cell lung cancer.  Journal Articles
• The use of glycoprotein IIb/IIIa receptor inhibitors in unstable angina.  Journal Articles
• The use of induced sputum in clinical trials  Journal Articles
• The use of surrogate endpoints in clinical trials: focus on clinical trials in cardiovascular diseases  Journal Articles
• The value of information and optimal clinical trial design  Journal Articles
• The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days  Journal Articles
• The worm turns: publication bias and trial registers revisited  Journal Articles
• Theophylline: Mechanism of action and use in asthma and chronic obstructive pulmonary disease  Journal Articles
• Therapeutic placebo in ulcerative colitis: fact or fiction?  Journal Articles
• Therapeutic targets and early stage clinical trials for pulmonary fibrosis  Journal Articles
• Therapeutic transcranial magnetic stimulation in migraine and its implications for a neuroinflammatory hypothesis  Journal Articles
• Therapy of Angina Pectoris with Low-Dose Perhexiline  Journal Articles
• Therapy of shock with naloxone  Conferences
• Thiazides for Patients with Recurrent Calcium Stones: Still an Open Question  Journal Articles
• Thinking Outside the Box: Recent Advances in the Analysis and Presentation of Uncertainty in Cost-Effectiveness Studies  Journal Articles
• Thrombolysis for restoration of patency to haemodialysis central venous catheters: a systematic review.  Journal Articles
• Thrombophilic polymorphism – a short‐term or long‐term risk for recurrence?  Journal Articles
• Thromboprophylaxis in Medical Patients – Why Not For All?  Conferences
• Thrombosis and cancer: implications beyond Trousseau  Journal Articles
• Thrombus Aspiration in ST-Segment–Elevation Myocardial Infarction  Journal Articles
• Thyrotropin-releasing hormone: differential antidepressant and endocrinological effects  Journal Articles
• Time and Expected Value of Sample Information Wait for No Patient  Journal Articles
• Time to rethink clinically important outcomes in platelet transfusion trials  Journal Articles
• Timing the First Postoperative Dose of Anticoagulants  Journal Articles
• Tips for Teachers of Evidence-Based Medicine: Understanding Odds Ratios and Their Relationship to Risk Ratios  Journal Articles
• Tips for learners of evidence-based medicine: 2. Measures of precision (confidence intervals)  Journal Articles
• To the editor:  Journal Articles
• To the editor: Are long‐acting beta‐agonists the “winning team” in childhood asthma?  Journal Articles
• Topical application of antifibrinolytic drugs for on-pump cardiac surgery: a systematic review and meta-analysis  Journal Articles
• Total knee arthroplasty using patient-specific instrumentation for osteoarthritis of the knee: a meta-analysis  Journal Articles
• Toward more specific and transparent research and development costs: The case of seasonal influenza vaccines  Journal Articles
• Towards Complete and Accurate Reporting of Studies of Diagnostic Accuracy: The STARD Initiative  Journal Articles
• Towards a consensus on diagnostic criteria, measurement and trial design of the premenstrual disorders: the ISPMD Montreal consensus  Journal Articles
• Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative  Journal Articles
• Towards full clinical trial registration and results publication: longitudinal meta-research study in Northwestern and Central Switzerland  Journal Articles
• Towards optimal endocrine therapy for hormone-sensitive breast cancer: Initial versus sequential adjuvant aromatase inhibition  Journal Articles
• Transforming the scientific, health care, and sociopolitical culture of an entire country through clinical research: The story of GISSI  Journal Articles
• Translating clinical trials to clinical practice: outcomes of men with metastatic castration resistant prostate cancer treated with docetaxel and prednisone in and out of clinical trials  Journal Articles
• Transparency, trust and minimizing burden to increase recruitment and retention in trials: a systematic review  Journal Articles
• Treatment of Child Neglect: A Systematic Review  Journal Articles
• Treatment of Cryptosporidiosis with Spiramycin in AIDS  Journal Articles
• Treatment of geographic atrophy: an update on data related to pegcetacoplan  Journal Articles
• Treatment of patients with acute nonlymphocytic leukemia in relapse: A leukemia intergroup study  Journal Articles
• Treatment of peptic ulcer disease with sucralfate: A review  Journal Articles
• Treatment of premenstrual dysphoria with selective serotonin re-uptake inhibitors: focus on safety  Journal Articles
• Treatment with novel oral anticoagulants  Journal Articles
• Trial Design Principles for Patients at High Bleeding Risk Undergoing PCI  Journal Articles
• Trial marketing in the Pan-Canadian Early Detection of Lung Cancer Study  Journal Articles
• Trial participation as avoidance strategy: a qualitative study.  Journal Articles
• Trials and tribulations: so many potential treatments, so few answers  Journal Articles
• Trifluoperazine: A comparison between regular and high doses  Journal Articles
• Trimipramine in rheumatoid arthritis: a randomized double-blind trial in relieving pain and joint tenderness  Journal Articles
• Understanding the Results of Meta-Analyses in the Treatment of Head and Neck Squamous Cell Cancer  Journal Articles
• Understanding the attitudes of the elderly towards enrolment into cancer clinical trials  Journal Articles
• Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma  Journal Articles
• Unmet Needs and Challenges in Clinical Research of Intracerebral Hemorrhage  Journal Articles
• Unresolved Issues in the Management of Hypertension  Journal Articles
• Unresolved issues in anticoagulant therapy  Conferences
• Unstable Angina and Non–ST-Elevation Myocardial Infarction  Journal Articles
• Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors’ Expert Forum  Journal Articles
• Updates in thrombosis in pediatrics: where are we after 20 years?  Journal Articles
• Uptake of core outcome sets in paediatric clinical trials: a protocol.  Journal Articles
• Urgent Clinical Challenges in Children With Ischemic Stroke  Journal Articles
• Urgently seeking efficiency and sustainability of clinical trials in global health  Journal Articles
• Use of Antithrombotic Agents During Pregnancy  Conferences
• Use of GRADE in evidence syntheses published in high-impact-factor nutrition journals: A methodological survey  Journal Articles
• Use of a Qualification Phantom for PET Brain Imaging in a Multicenter Consortium: A Collaboration Between the Pediatric Brain Tumor Consortium and the SNMMI Clinical Trials Network  Journal Articles
• Use of stable isotopes to determine compliance  Journal Articles
• User's Guide to a Meta-Analysis about an Orthopaedic Implant  Journal Articles
• Users' Guides to the Medical Literature  Journal Articles
• Users' Guides to the Medical Literature  Journal Articles
• Users' guide to detecting misleading claims in research: Misleading claims may be symptom of even more serious flaws  Journal Articles
• Users' guides to the medical literature. II. How to use an article about therapy or prevention. A. Are the results of the study valid? Evidence-Based Medicine Working Group  Journal Articles
• Using Humanistic Health Outcomes Data in Asthma  Journal Articles
• Using Value-of-Information Methods when the Disease Is Rare and the Treatment Is Expensive—The Example of Hemophilia A  Journal Articles
• Using baseline measurements in the two-period crossover clinical trial  Journal Articles
• Using the Maximum Test Statistic in the Two-Period Crossover Clinical Trial  Journal Articles
• Vagal Afferent Stimulation as a Cardioprotective Strategy? Introducing the Concept  Journal Articles
• Validation of pH Dataloggers for Pharmacologic Studies  Journal Articles
• Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.  Journal Articles
• Value of Information and Pricing New Healthcare Interventions  Journal Articles
• Variation in mantle technique: implications for establishing priorities for quality assurance in clinical trials  Journal Articles
• Variation in outcome reporting in studies on obesity in pregnancy—A systematic review  Journal Articles
• Vasopressin in pediatric shock and cardiac arrest  Journal Articles
• Venous and arterial thrombosis – pathogenesis and the rationale for anticoagulation  Journal Articles
• Venous thromboembolism prophylaxis: do trial results enable clinicians and patients to evaluate whether the benefits justify the risk? Proceedings of an Ad Hoc Working Group Meeting  Journal Articles
• Venous thromboembolism, age and hospitalisation: A potentially deadly combination  Journal Articles
• Venous thromboembolism: Past, present and future  Journal Articles
• Venous thrombosis in children  Journal Articles
• Verapamil following uncomplicated myocardial infarction: Promising, but not proven  Journal Articles
• Vitamin A sensitivity.  Journal Articles
• Vitamin D supplementation in children with asthma: a systematic review and meta-analysis  Journal Articles
• Vitamin D supplementation in primary allergy prevention: Systematic review of randomized and non‐randomized studies  Journal Articles
• Von Willebrand factor and thrombin activation in children with newly diagnosed acute lymphoblastic leukemia: An impact of peripheral blasts  Journal Articles
• WORK-SITE TREATMENT OF HYPERTENSION BY SPECIALLY TRAINED NURSES  Journal Articles
• Waiving confidentiality for the greater good  Journal Articles
• Warfarin Sodium versus Low-Dose Heparin in the Long-Term Treatment of Venous Thrombosis  Journal Articles
• Weaning from mechanical ventilation: the evidence from clinical research.  Journal Articles
• What Does the Evidence Tell Us About Design of Future Treatment Trials for Whiplash-Associated Disorders?  Journal Articles
• What Is Involved in a Regulatory Trial Investigating a New Medical Device?  Journal Articles
• What are the information priorities for cancer patients involved in treatment decisions? An experienced surrogate study in Hodgkin's disease  Journal Articles
• What do the results of the PRoFESS trial teach us?  Journal Articles
• What does it take to put an ugly fact through the heart of a beautiful hypothesis?  Journal Articles
• What happens to intimate partner violence studies registered on clinicaltrials.gov? A systematic review of a clinical trials registry  Journal Articles
• What have we learnt about asthma control from trials of budesonide/formoterol as maintenance and reliever?  Journal Articles
• What is a cure and how do we get there?  Journal Articles
• What is the role of invasive versus non‐invasive coronary angiography in the investigation of patients suspected to have coronary heart disease?  Journal Articles
• When is a meta-analysis conclusive? A guide to Trial Sequential Analysis with an example of remote ischemic preconditioning for renoprotection in patients undergoing cardiac surgery  Journal Articles
• Which cancer clinical trials should be considered for economic evaluation? Selection criteria from the National Cancer Institute of Canada's Working Group on Economic Analysis.  Journal Articles
• Who is fooling us?  Journal Articles
• Who says “no” to participating in stroke clinical trials and why: an observational study from the Vancouver Stroke Program  Journal Articles
• Why do we need some large, simple randomized trials?  Journal Articles
• Why would a sane clinician not prescribe prophylactic indomethacin?  Journal Articles
• Ximelagatran: the first oral direct thrombin inhibitor  Journal Articles
• Ximelagatran: the first oral direct thrombin inhibitor.  Journal Articles
• Yttrium 90 ibritumomab tiuxetan in lymphoma  Journal Articles
• [After the HOPE Study. ACE inhibitor now for every diabetic patient?. Interview by Dr. Dirk Einecke].  Journal Articles
• [Antithrombotic treatment of atrial fibrillation].  Journal Articles
• [Effect of atenolol on the QT interval in the acute phase of myocardial infarction].  Journal Articles
• [Four numbers and basic knowledge of mathematics].  Journal Articles
• [More fetal monitoring, more cesarean sections? An attempt at meta-analysis of the problem].  Journal Articles
• [Non invasive mechanical ventilation in acute cardiogenic pulmonary edema: is it all done?].  Journal Articles
• [The number needed to treat (NNT) and the number needed to harm (NNH)].  Journal Articles
• [Why bother with regression models?].  Journal Articles
• pH, healing rate and symptom relief in acid-related diseases.  Journal Articles
• pH, healing rate, and symptom relief in patients with GERD.  Journal Articles
• Ácido tranexâmico no tratamento da hemorragia no trauma  Journal Articles
• “I don’t need any more unknowns hanging over my head”: Views of patients with cancer on variants of uncertain significance and low/moderate risk results from genomic sequencing  Journal Articles
• “Pragmatic” clinical trials: from whose perspective?  Journal Articles
• “Therapeutic Range” for Oral Anticoagulant Therapy  Journal Articles