Journal article
The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease
Abstract
Among the pathophysiological derangements operating in the chronic phase of Chagas disease, parasite persistence is likely to constitute the main mechanism of myocardial injury in patients with chronic chagasic cardiomyopathy. The presence of Trypanosoma cruzi in the heart causes a low-grade, but relentless, inflammatory process and induces myocardial autoimmune injury. These facts suggest that trypanocidal therapy may positively impact the …
Authors
Marin-Neto JA; Rassi A; Avezum A; Mattos AC; Rassi A; Morillo CA; Sosa-Estani S; Yusuf S
Journal
Memórias do Instituto Oswaldo Cruz, Vol. 104, No. suppl 1, pp. 319–324
Publisher
FapUNIFESP (SciELO)
Publication Date
July 2009
DOI
10.1590/s0074-02762009000900042
ISSN
0074-0276