Recommended Patient-Reported Core Set of Symptoms to Measure in Prostate Cancer Treatment Trials Journal Articles uri icon

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  • The National Cancer Institute (NCI) Symptom Management and Health-Related Quality of Life Steering Committee convened four working groups to recommend core sets of patient-reported outcomes to be routinely incorporated in clinical trials. The Prostate Cancer Working Group included physicians, researchers, and a patient advocate. The group's process included 1) a systematic literature review to determine the prevalence and severity of symptoms, 2) a multistakeholder meeting sponsored by the NCI to review the evidence and build consensus, and 3) a postmeeting expert panel synthesis of findings to finalize recommendations. Five domains were recommended for localized prostate cancer: urinary incontinence, urinary obstruction and irritation, bowel-related symptoms, sexual dysfunction, and hormonal symptoms. Four domains were recommended for advanced prostate cancer: pain, fatigue, mental well-being, and physical well-being. Additional domains for consideration include decisional regret, satisfaction with care, and anxiety related to prostate cancer. These recommendations have been endorsed by the NCI for implementation.


  • Chen, Ronald C
  • Chang, Peter
  • Vetter, Richard J
  • Lukka, Himu
  • Stokes, William A
  • Sanda, Martin G
  • Watkins-Bruner, Deborah
  • Reeve, Bryce B
  • Sandler, Howard M

publication date

  • July 2014

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