Journal article
Favorable Pharmacokinetic Characteristics of Extended-Half-Life Recombinant Factor VIII BAY 94-9027 Enable Robust Individual Profiling Using a Population Pharmacokinetic Approach
Abstract
BackgroundProphylaxis with factor VIII (FVIII) should be individualized based on patient characteristics, including FVIII pharmacokinetics. Population pharmacokinetic (popPK) modeling simplifies pharmacokinetic studies by obviating the need for multiple samples.ObjectiveThe objective of this study was to characterize the pharmacokinetics and inter-individual variability (IIV) of BAY 94-9027 in relation to patient characteristics in support of a …
Authors
Solms A; Iorio A; Ahsman MJ; Vis P; Shah A; Berntorp E; Garmann D
Journal
Clinical Pharmacokinetics, Vol. 59, No. 5, pp. 605–616
Publisher
Springer Nature
Publication Date
May 2020
DOI
10.1007/s40262-019-00832-7
ISSN
0312-5963