Journal article
Methodologic discussions for using and interpreting composite endpoints are limited, but still identify major concerns
Abstract
OBJECTIVE: To investigate the rationale, potential problems and solutions of using composite endpoints (CEPs) for the assessment of intervention effects.
STUDY DESIGN AND SETTING: This study is a systematic review. We searched MEDLINE, EMBASE, and the Science Citation Index, for publications appearing between 1980 and September 2005, and reviewed potentially informative textbooks. Eligible articles provided a commentary, analysis, or discussion …
Authors
Ferreira-González I; Permanyer-Miralda G; Busse JW; Bryant DM; Montori VM; Alonso-Coello P; Walter SD; Guyatt GH
Journal
Journal of Clinical Epidemiology, Vol. 60, No. 7, pp. 651–657
Publisher
Elsevier
Publication Date
July 2007
DOI
10.1016/j.jclinepi.2006.10.020
ISSN
0895-4356