Journal article
Elimination of 4-n-Butoxyphenylacethydroxamic Acid (Bufexamac) in Man
Abstract
A GLC determination showed that about 80% of a dose of bufexamac (125–500 mg.) can be recovered from urine after acid hydrolysis as 4-n-butoxyphenylacetic acid. Excretion is apparently complete within 24 hr. Not more than 1% of the dose is excreted as free bufexamac or 4-butoxyphenylacetic acid. Enzymic hydrolysis indicated that about 75% of the dose is excreted with the hydroxamic function intact and that the elimination of bufexamac is mainly …
Authors
Boreham DR; Cummings AJ; Dell D; Martin BK
Journal
Journal of Pharmaceutical Sciences, Vol. 61, No. 2, pp. 164–168
Publisher
Elsevier
Publication Date
2 1972
DOI
10.1002/jps.2600610203
ISSN
1520-6017