RANITIDINE 150 mg TWICE DAILY VS 300 mg NIGHTLY IN TREATMENT OF DUODENAL ULCERS Academic Article uri icon

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abstract

  • 102 patients with endoscopically proven duodenal ulcers were randomly allocated to treatment with ranitidine either 150 mg twice a day or 300 mg every evening for 4 weeks in a prospective double-blind study. The two groups were similar. 48/57 (84%) healed on ranitidine 150 mg twice daily and 43/45 (96%) healed on 300 mg every evening (p = 0.9)--that is, ranitidine 300 mg as a single night time dose is as effective as 150 mg twice daily. The results also indicate the importance of overnight gastric acidity in the pathogenesis of duodenal ulcers.

authors

  • Ireland, A
  • Gear, P
  • Jones, DG Colin
  • Golding, PL
  • Ramage, JK
  • Williams, JG
  • Leicester, RJ
  • Smith, CL
  • Ross, G
  • Bamforth, J
  • Degara, CJ
  • Gledhill, T
  • Hunt, Richard H

publication date

  • August 1984