Is it possible to reduce cardiovascular risk with glucose-lowering approaches?

Glucose control does not have a clear cardiovascular benefit in people with established, long-duration diabetes mellitus; however, it reduces the risk of diabetes-related eye disease and kidney disease, myocardial infarction and mortality in those with recent-onset diabetes mellitus. Here, the author discusses the relationship between blood glucose level and cardiovascular disease and compares the cardiovascular effects of various glucose-lowering drugs and strategies.