Journal article
Evolution of Heterogeneity (I2) Estimates and Their 95% Confidence Intervals in Large Meta-Analyses
Abstract
BACKGROUND: Assessment of heterogeneity is essential in systematic reviews and meta-analyses of clinical trials. The most commonly used heterogeneity measure, I(2), provides an estimate of the proportion of variability in a meta-analysis that is explained by differences between the included trials rather than by sampling error. Recent studies have raised concerns about the reliability of I(2) estimates, due to their dependence on the precision …
Authors
Thorlund K; Imberger G; Johnston BC; Walsh M; Awad T; Thabane L; Gluud C; Devereaux PJ; Wetterslev J
Journal
PLOS ONE, Vol. 7, No. 7,
Publisher
Public Library of Science (PLoS)
Publication Date
2012
DOI
10.1371/journal.pone.0039471
ISSN
1932-6203