Journal article
RANDOMISED COMPARISON OF TWO INTENSITIES OF ORAL ANTICOAGULANT THERAPY AFTER TISSUE HEART VALVE REPLACEMENT
Abstract
After tissue heart valve replacement 108 patients were randomised to standard anticoagulant control with rabbit brain thromboplastin (Dade C reagent, therapeutic range 18-24 s; international normalised ratio 2.5-40) and 102 to a less intensive regimen controlled with human brain thromboplastin (Manchester Comparative Reagent, therapeutic range 26-30 s; INR 2.0-2.25). Treatment was continued for three months, outcome measures being major or …
Authors
Turpie AG; Hirsh J; Gunstensen J; Nelson H; Gent M
Journal
The Lancet, Vol. 331, No. 8597, pp. 1242–1245
Publisher
Elsevier
Publication Date
June 1988
DOI
10.1016/s0140-6736(88)92070-3
ISSN
0140-6736