Journal article
The architecture of diagnostic research: From bench to bedside—research guidelines using liver stiffness as an example
Abstract
The diagnostic research process can be divided into five phases, designed to establish the clinical utility of a new diagnostic test--the index test. The aim of the present review is to illustrate the study designs that are appropriate for each diagnostic phase, using clinical examples regarding liver fibrosis diagnosed with transient elastography, when possible. Phase 0 is the preclinical pilot phase during which the validity, reliability, and …
Authors
Colli A; Fraquelli M; Casazza G; Conte D; Nikolova D; Duca P; Thorlund K; Gluud C
Journal
Hepatology, Vol. 60, No. 1, pp. 408–418
Publisher
Wolters Kluwer
Publication Date
July 2014
DOI
10.1002/hep.26948
ISSN
0270-9139