Limitation of myocardial infarction by early infusion of recombinant tissue-type plasminogen activator. Academic Article uri icon

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abstract

  • In a double-blind randomized trial involving five Sydney hospitals and the city ambulance paramedical service, 145 patients with a first evolving myocardial infarction and with onset of pain less than 2.5 (mean 1.9 +/- 0.5 [SD]) hr previously were allocated to intravenous infusion of 100 mg recombinant tissue-type plasminogen activator (rt-PA) or placebo over 3 hr. The groups at entry were similar. At assessment 21 days later, left ventricular ejection fraction measured both by contrast and radionuclide ventriculography was higher in the rt-PA compared with the placebo group (61 +/- 13%, n = 64, vs 54 +/- 14%, n = 62, contrast, 2p = .006; 52 +/- 13%, n = 66, vs 48 +/- 13%, n = 62 isotope, 2p = .08). This indicates limitation of myocardial infarction by rt-PA.

authors

  • Whitlock, Richard
  • O'Rourke, M
  • Baron, D
  • Keogh, A
  • Kelly, R
  • Nelson, G
  • Barnes, C
  • Raftos, J
  • Graham, K
  • Hillman, K
  • Newman, H

publication date

  • June 1988

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