Therapy of Angina Pectoris with Low-Dose Perhexiline

We conducted a double-blind, crossover study into the effect of 100 mg of perhexiline maleate twice daily on the response to exercise of 15 patients with proven ischemic heart disease. Patients were evaluated by bicycle ergometry, on three occasions, before treatment and after 2 weeks of treatment with placebo or perhexiline. Patients were able to exercise for a longer period as shown by comparing perhexiline to pretreatment (mean change, 54.9%;…