Growth Hormone Therapy in Heart Failure: Where Are We Now? Journal Articles

abstract

• Despite improvement in survival with angiotensin‐converting enzyme inhibitors and blockers, clinical events for patients with heart failure remain elevated. New therapies for heart failure are needed to improve functional capacity, quality of life, and prognosis. Growth hormone exerts direct and indirect effects on cardiac structure and function. Experimental models of heart failure and small studies have demonstrated significant improvements in cardiac function, hemodynamic parameters, functional capacity, and quality of life. Despite the lack of benefit demonstrated in small, short‐term, randomized clinical trials, further studies are needed to assess the potential role of this adjuvant therapy in heart failure patients.

authors

• Demers, Catherine
• McKelvie, Robert

status

• published 

publication date

• March 2003

has subject area

• 1102 Cardiorespiratory Medicine and Haematology (FoR)
• Animals (MeSH)
• Cardiovascular System & Hematology (Science Metrix)
• Clinical Trials as Topic (MeSH)
• Growth Hormone (MeSH)
• Heart Failure (MeSH)
• Hemodynamics (MeSH)
• Humans (MeSH)
• Insulin-Like Growth Factor I (MeSH)
• Myocardial Contraction (MeSH)
• Quality of Life (MeSH)
• Ventricular Remodeling (MeSH)

published in

• Congestive Heart Failure  Journal

keywords

• Animals
• Clinical Trials as Topic
• Growth Hormone
• Heart Failure
• Hemodynamics
• Humans
• Insulin-Like Growth Factor I
• Myocardial Contraction
• Quality of Life
• Ventricular Remodeling

Digital Object Identifier (DOI)

• 10.1111/j.1527-5299.2003.00283.x

PubMed ID

• 12671339

start page

• 84

end page

• 90

volume

• 9

issue

• 2