Journal article
Comparison of total event analysis and first event analysis in relation to heterogeneity in cardiovascular trials
Abstract
BackgroundIn cardiovascular (CV) trials, analyzing the total number of events, rather than just time-to-first event, enhances understanding of participants' health. Adapting Cox models to account for between-subject heterogeneity in multiple events and understanding its impact plays crucial roles in total event analysis.MethodThis study compares effect sizes from first event and total event analyses in three cardiovascular trials: ORIGIN …
Authors
Lee S-F; Ramasundarahettige C; Gerstein HC; McIntyre WF; Eikelboom J; O’Donnell MJ; Zhou Y; Bangdiwala SI; Thabane L
Journal
BMC Medical Research Methodology, Vol. 25, No. 1,
Publisher
Springer Nature
DOI
10.1186/s12874-025-02593-3
ISSN
1471-2288