Journal article
An overview of precision oncology basket and umbrella trials for clinicians
Abstract
With advancements in biomarkers and momentum in precision medicine, biomarker-guided trials such as basket trials and umbrella trials have been developed under the master protocol framework. A master protocol refers to a single, overarching design developed to evaluate multiple hypotheses with the general goal of improving the efficiency of trial evaluation. One type of master protocol is the basket trial, in which a targeted therapy is …
Authors
Park JJH; Hsu G; Siden EG; Thorlund K; Mills EJ
Journal
CA A Cancer Journal for Clinicians, Vol. 70, No. 2, pp. 125–137
Publisher
Wiley
Publication Date
March 2020
DOI
10.3322/caac.21600
ISSN
0007-9235