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Using Value-of-Information Methods when the...
Journal article

Using Value-of-Information Methods when the Disease Is Rare and the Treatment Is Expensive—The Example of Hemophilia A

Abstract

ABSTRACTBACKGROUNDHemophilia A is a rare, sex-linked genetic disorder treated with intravenous administration of factor VIII (FVIII) to prevent bleeding; however, approaches vary across and within countries. Value-of-information (VOI) methods identify situations in which the cost-benefit evidence is sufficient to adopt one treatment strategy over another; when the evidence is insufficient, VOI methods provide the optimal sample size for …

Authors

Abrahamyan L; Willan AR; Beyene J; Mclimont M; Blanchette V; Feldman BM; for the Canadian Hemophilia Primary Prophylaxis (CHPS) Study Group

Journal

Journal of General Internal Medicine, Vol. 29, No. Suppl 3, pp. 767–773

Publisher

Springer Nature

Publication Date

August 2014

DOI

10.1007/s11606-014-2880-3

ISSN

0884-8734