Journal article
Using Value-of-Information Methods when the Disease Is Rare and the Treatment Is Expensive—The Example of Hemophilia A
Abstract
ABSTRACTBACKGROUNDHemophilia A is a rare, sex-linked genetic disorder treated with intravenous administration of factor VIII (FVIII) to prevent bleeding; however, approaches vary across and within countries. Value-of-information (VOI) methods identify situations in which the cost-benefit evidence is sufficient to adopt one treatment strategy over another; when the evidence is insufficient, VOI methods provide the optimal sample size for …
Authors
Abrahamyan L; Willan AR; Beyene J; Mclimont M; Blanchette V; Feldman BM; for the Canadian Hemophilia Primary Prophylaxis (CHPS) Study Group
Journal
Journal of General Internal Medicine, Vol. 29, No. Suppl 3, pp. 767–773
Publisher
Springer Nature
Publication Date
August 2014
DOI
10.1007/s11606-014-2880-3
ISSN
0884-8734