Journal article
In the Era of Systematic Reviews, Does the Size of an Individual Trial Still Matter?
Abstract
BACKGROUND TO THE DEBATE: Systematic reviews that combine high-quality evidence from several trials are now widely considered to be at the top of the hierarchy of clinical evidence. Given the primacy of systematic reviews-and the fact that individual clinical trials rarely provide definitive answers to a clinical research question-some commentators question whether the sample size calculation for an individual trial still matters. Others point …
Authors
Guyatt GH; Mills EJ; Elbourne D
Journal
PLOS Medicine, Vol. 5, No. 1,
Publisher
Public Library of Science (PLoS)
Publication Date
January 3, 2008
DOI
10.1371/journal.pmed.0050004
ISSN
1549-1277