Sample Size in the Planning and Interpretation of Clinical Trials Journal Articles

abstract

• AbstractAn understanding of sample size determination is important in both planning and interpreting the results of clinical trials. A Type II error occurs when it is concluded that there is no difference between treatment groups, when in truth there is a difference. Such a false negative conclusion results from too few patients in a trial. In this review the principles of estimating sample size before a trial is commenced and evaluating the results of a negative completed trial are reviewed. Clinically relevant examples are used to illustrate these concepts.

authors

• Levine, Mark Norman
• Hirsh, Jack

status

• published 

publication date

• 1987

has subject area

• 1102 Cardiorespiratory Medicine and Haematology (FoR)
• 1103 Clinical Sciences (FoR)
• Biometry (MeSH)
• Cardiovascular System & Hematology (Science Metrix)
• Clinical Trials as Topic (MeSH)
• Humans (MeSH)
• Sampling Studies (MeSH)

published in

• Thrombosis and Haemostasis  Journal

keywords

• Biometry
• Clinical Trials as Topic
• Humans
• Sampling Studies

Digital Object Identifier (DOI)

• 10.1055/s-0038-1646033

PubMed ID

• 3328321

start page

• 953

end page

• 956

volume

• 58

issue

• 04