Journal article
DEVELOPMENT OF ANTI-IDIOTYPIC ANTIBODIES AGAINST TUMOUR ANTIGENS AND AUTOANTIGENS IN OVARIAN CANCER PATIENTS TREATED INTRAPERITONEALLY WITH MOUSE MONOCLONAL ANTIBODIES
Abstract
Repeated intraperitoneal administration of therapeutic amounts of radiolabelled (iodine-131) murine monoclonal antibodies leads to the development of an immune response in the recipient, part of which is directed against the variable region (idiotype) of the administered antibody (anti-Id1 response). Human immunoglobulin purified from these patients inhibits binding of the original murine monoclonal antibody to its target tumour antigen and …
Authors
Courtenay-Luck N; Epenetos A; Sivolapenko G; Barkans J; Larche M; Ritter M
Journal
The Lancet, Vol. 332, No. 8616, pp. 894–897
Publisher
Elsevier
Publication Date
October 1988
DOI
10.1016/s0140-6736(88)92482-8
ISSN
0140-6736