Journal article
The Protective Effect of Inhaled Chlorpheniramine and Atropine on Bronchoconstriction Stimulated by Airway Cooling1–3
Abstract
We examined the role of histamine release and reflex bronchoconstriction in the bronchoconstriction stimulated by airway cooling. In 8 asthmatic subjects, dose-response curves were determined to isocapnic hyperventilation of cold air 30 min after inhalation of chlorpheniramine maleate (18 mg nebulized during tidal breathing), 2 doses of atropine sulphate (3 mg and 18 mg nebulized), or placebo. Treatments were given on separate days, in random …
Authors
O'Byrne PM; Thomson NC; Morris M; Roberts RS; Daniel EE; Hargreave FE
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 128, No. 4, pp. 611–617
Publication Date
10 1983
DOI
10.1164/arrd.1983.128.4.611
ISSN
1073-449X