Journal article
Should recommendations about starting inhaled corticosteroid treatment for mild asthma be based on symptom frequency: a post-hoc efficacy analysis of the START study
Abstract
BACKGROUND: Low-dose inhaled corticosteroids (ICS) are highly effective for reducing asthma exacerbations and mortality. Conventionally, ICS treatment is recommended for patients with symptoms on more than 2 days per week, but this criterion has scant evidence. We aimed to assess the validity of the previous symptom-based cutoff for starting ICS by establishing whether there was a differential response to budesonide versus placebo for severe …
Authors
Reddel HK; Busse WW; Pedersen S; Tan WC; Chen Y-Z; Jorup C; Lythgoe D; O'Byrne PM
Journal
The Lancet, Vol. 389, No. 10065, pp. 157–166
Publisher
Elsevier
Publication Date
January 2017
DOI
10.1016/s0140-6736(16)31399-x
ISSN
0140-6736