Cutaneous responses to tests with influenza vaccines.

Responses to the intracutaneous infection of influenza vaccines were examined at 24 and 48 hours. Whole virus and subunit virus vaccines of comparable potency induced local reactions of comparable magnitude. Cutaneous reactions to the influenza vaccines were present in almost all adults but absent in young children. Reactions were greatly reduced by ingested prednisone. Responses to a subunit commercial trivalent influenza vaccine were compared …