Structure-Activity Relationship Concept

subject area of

• .beta.-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22  Academic Article
• 1,4-Dihydropyridine Scaffold in Medicinal Chemistry, The Story so Far And Perspectives (Part 1): Action in Ion Channels and GPCRs  Academic Article
• 2 Mechanisms of action of low molecular weight heparins and heparinoids  Academic Article
• 2-[125I]Iodomelatonin binding sites in the quail heart: Characteristics, distribution and modulation by guanine nucleotides and cations  Academic Article
• 3D organization and function of the cell: Golgi budding and vesicle biogenesis to docking at the porosome complex  Academic Article
• 4-Aryl-3-(hydroxyalkyl)quinolin-2-ones:  Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction  Academic Article
• A 2.13 Å Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region  Academic Article
• A 23bp Insertion in the Endothelial Protein C Receptor (EPCR) Gene Impairs EPCR Function  Academic Article
• A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using ^99mTc- and ¹⁷⁷Lu-Labeled Tetrazines  Academic Article
• A Highly Dynamic Loop of the Pseudomonas aeruginosa PA14 Type IV Pilin Is Essential for Pilus Assembly  Academic Article
• A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor  Academic Article
• A Refined Model for the Somatostatin Pharmacophore:  Conformational Analysis of Lanthionine−Sandostatin Analogs  Academic Article
• A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome  Academic Article
• A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection  Academic Article
• A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase  Academic Article
• A comprehensive study of genic variation in natural populations of Drosophila melanogaster. V. Structural–functional constraints on protein molecules and enzymes and the levels and patterns of variation among genes  Academic Article
• A densitometric study of the effects of free fatty acids on the phase transition of dimyristoylphosphatidylcholine bilayers  Academic Article
• A fast and sensitive method for the analysis of modified nucleosides in tRNA  Academic Article
• A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both α- and β-ketone reduction during chain growth  Academic Article
• A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function  Academic Article
• A proposal: That the heterogeneity of glycoprotein N-glycans is a feature of their biosynthesis and may be of functional significance  Academic Article
• A recurrent de novo HSPD1 variant is associated with hypomyelinating leukodystrophy  Academic Article
• Action of insulin in rat adipocytes and membrane properties  Academic Article
• Aliphatic aldehydes promote myelin basic protein-induced fusion of phospholipid vesicles  Academic Article
• Allosteric Modulation of the Dopamine D₂ Receptor by Pro-Leu-Gly-NH₂ Peptidomimetics Constrained in Either a Polyproline II Helix or a Type II β-Turn Conformation  Academic Article
• Altering Heparin Cofactor II at VAL439 (P6) either Impairs Inhibition of Thrombin or Confers Elastase Resistance  Academic Article
• Amino acid substitutions of the P2 residue of human antithrombin that either enhance or impair function  Academic Article
• Aminorifamycins and Sporalactams Produced in Culture by a Micromonospora sp. Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics  Academic Article
• An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria  Academic Article
• Antagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues  Academic Article
• Antibiotics as probes of biological complexity  Academic Article
• Antibodies to Catecholamines  Academic Article
• Antibodies to Indolealkylamines; Serotonin and Melatonin  Academic Article
• Antimitotic activity of structurally simplified biaryl analogs of the anticancer agents colchicine and combretastatin A4  Academic Article
• Antineoplastic Agents 491.¹ Synthetic Conversion of Aaptamine to Isoaaptamine, 9-Demethylaaptamine, and 4-Methylaaptamine  Academic Article
• Aortic smooth muscle and endothelial plasma membrane Ca²⁺pump isoforms are inhibited differently by the extracellular inhibitor caloxin 1b1  Academic Article
• Application of Combinatorial Libraries and Protein Engineering to the Discovery of Novel Anti-Thrombotic Drugs  Conference Paper
• Architecture of the Neuronal Nicotinic Acetylcholine Receptor Ion Channel at the Binding Site of bis-Ammonium Blockers  Academic Article
• Are the pharmacological effects of L-prolyl-L-leucylglycinamide (PLG) mediated through specific receptor mechanisms?  Academic Article
• Arginine Methylation Regulates Telomere Length and Stability  Academic Article
• Arginine-lysine positional swap of the LL-37 peptides reveals evolutional advantages of the native sequence and leads to bacterial probes  Academic Article
• Bacterial Membranes as Predictors of Antimicrobial Potency  Academic Article
• Basis for Selectivity of Cationic Antimicrobial Peptides for Bacterial Versus Mammalian Membranes  Academic Article
• Bicyclic thiazolidine lactam peptidomimetics of the dopamine receptor modulating peptide Pro-Leu-Gly-NH2  Academic Article
• Bimolecular Hydrogen Abstraction from Phenols by Aromatic Ketone Triplets†  Academic Article
• Bioactive paper dipstick sensors for acetylcholinesterase inhibitors based on sol–gel/enzyme/gold nanoparticle composites  Academic Article
• Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”  Academic Article
• Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor  Academic Article
• Biological activity of metabolites of PGD2 on canine proximal colon  Academic Article
• Biologically active calcitonin analogs which have minimal interactions with phospholipids  Academic Article
• Biologically potent analogues of salmon calcitonin which do not contain an N-terminal disulfide-bridged ring structure  Academic Article
• Biosynthesis of Vitamin B₆. Incorporation of Terminally Labelled Glucose  Academic Article
• Biosynthetic utilization of photoreactive fatty acids by rat liver microsomes  Academic Article
• Broad and Differential Animal Angiotensin-Converting Enzyme 2 Receptor Usage by SARS-CoV-2  Academic Article
• Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes  Academic Article
• Ca2+-dependent Antifreeze Proteins  Academic Article
• Capping DNA with DNA  Academic Article
• Carbapenems and Lipid Bilayers: Localization, Partitioning, and Energetics  Academic Article
• Cationic Liposomes for Direct Gene Transfer in Therapy of Cancer and Other Diseases  Academic Article
• Cephalosporin-induced hypoprothrombinemia: is the N-methylthiotetrazole side chain the culprit?  Academic Article
• Ceragenins (Cationic Steroid Compounds), a novel class of antimicrobial agents  Academic Article
• Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73  Academic Article
• Characterization and Biologic Activities of Recombinant Rat Soluble Interleukin-6 Receptor  Academic Article
• Characterization of a Distinctive Motif of the Low Molecular Weight Neurotrophin Receptor that Modulates NGF-mediated Neurite Growth  Academic Article
• Characterization of the putative fusogenic domain in vesicular stomatitis virus glycoprotein G  Academic Article
• Chloride Channels of Glycine and GABA Receptors with Blockers: Monte Carlo Minimization and Structure-Activity Relationships  Academic Article
• Circular dichroism (CD) studies of antagonists derived from parathyroid hormone-related protein  Academic Article
• Cold Stress Makes Escherichia coli Susceptible to Glycopeptide Antibiotics by Altering Outer Membrane Integrity  Academic Article
• Comparative biochemistry of cytochrome c oxidase in animals  Academic Article
• Comparison of Heparin- and Dermatan Sulfate-mediated Catalysis of Thrombin Inactivation by Heparin Cofactor II  Academic Article
• Conformation of a synthetic hexapeptide substrate of collagen lysyl hydroxylase  Academic Article
• Conformational Analysis of the Ca²⁺-Bound Opioid Peptides: Implications for Ligand-Receptor Interaction  Academic Article
• Conformational and biological properties of glucagon fragments containing residues 1-17 and 19-29  Academic Article
• Conformational determinants in receptor recognition of peptide hormones: interaction of parathyroid hormone with the glucagon receptor  Academic Article
• Conformational studies on analogs of recombinant parathyroid hormone and  Academic Article
• Cooperativity of papain-substrate interaction energies in the S2 to S2' subsites  Academic Article
• Cross-chimeric analysis of selectivity of secretin and VPAC(1) receptor activation.  Academic Article
• Crystal Structure of a Ca2+-discharged Photoprotein  Academic Article
• Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases  Academic Article
• Cytochrome P450 3A4 Inhibitory Activity Studies within the Lycorine series of Alkaloids  Academic Article
• Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape  Academic Article
• Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA  Academic Article
• Deletion sequences of salmon calcitonin that retain the essential biological and conformational features of the intact molecule  Academic Article
• Design and Characterization of a Broad -Spectrum Bactericidal Acyl-lysyl Oligomer  Academic Article
• Design and Synthesis of Photoaffinity-Labeling Ligands of the l-Prolyl-l-leucylglycinamide Binding Site Involved in the Allosteric Modulation of the Dopamine Receptor  Academic Article
• Design and synthesis of [ 125 I]Pyricoxib: A novel 125 I-labeled cyclooxygenase-2 (COX-2) inhibitors  Academic Article
• Design of Novel Rho Kinase Inhibitors Using Energy Based Pharmacophore Modeling, Shape-Based Screening, in Silico Virtual Screening, and Biological Evaluation  Academic Article
• Design, Synthesis, and Dopamine Receptor Modulating Activity of Spiro Bicyclic Peptidomimetics of l-Prolyl-l-leucyl-glycinamide  Academic Article
• Development of a specific assay for cardiac glycoside-like compounds based on cross-resistance of human cell mutants  Academic Article
• Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents  Academic Article
• Dimensions of the ion channel in neuronal nicotinic acetylcholine receptor as estimated from analysis of conformation-activity relationships of open-channel blocking drugs  Academic Article
• Dimerization of the P-glycoprotein in membranes  Academic Article
• Dinucleotide Junction Cleavage Versatility of 8-17 Deoxyribozyme  Academic Article
• Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.  Academic Article
• Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma  Academic Article
• Discovery of a Novel Series of Tricyclic Oxadiazine 4a-Methyl Esters Based on Indoxacarb as Potential Sodium Channel Blocker/Modulator Insecticides  Academic Article
• Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1)  Academic Article
• Discovery of a novel class of aldol-derived 1,2,3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase)  Academic Article
• Discovery of potent antiviral (HSV-1) quinazolinones and initial structure-activity relationship studies  Academic Article
• Divergent structural requirements exist for calcitonin receptor binding specificity and adenylate cyclase activation.  Academic Article
• Dopamine receptor modulation by Pro-Leu-Gly-NH2 analogs possessing cyclic amino acid residues at the C-terminal position  Academic Article
• Dopamine receptor modulation by conformationally constrained analogs of Pro-Leu-Gly-NH2  Academic Article
• Down-regulation of haloperidol-induced striatal dopamine receptor supersensitivity by active analogues of L-prolyl-L-leucyl-glycinamide (PLG)  Academic Article
• Drug evaluation: AP-23573--an mTOR inhibitor for the treatment of cancer.  Academic Article
• Drug evaluation: E-5564.  Academic Article
• EFFECTS OF TETRANDRINE AND CLOSELY RELATED BIS-BENZYLISOQUINOLINE DERIVATIVES ON CYTOSOLIC Ca²⁺IN HUMAN LEUKAEMIC HL-60 CELLS: A STRUCTURE-ACTIVITY RELATIONSHIP STUDY  Academic Article
• Effect of Lipid Structure on the Capacity of Myelin Basic Protein to Alter Vesicle Properties: Potent Effects of Aliphatic Aldehydes in Promoting Basic Protein-Induced Vesicle Aggregation  Academic Article
• Effect of magainin, class L, and class A amphipathic peptides on fatty acid spin labels in lipid bilayers  Academic Article
• Effect of microheterogeneity on the structure and function of the myelin basic protein  Academic Article
• Effect of specific trinitrophenylation of the lysine epsilon amino group of glucagon on receptor binding and adenylate cyclase activation  Academic Article
• Effects of heparin, its low molecular weight fractions and other glycosaminoglycans on thrombus growth  Academic Article
• Effects of lipid structure on peptide-lipid interactions complexes of salmon calcitonin with phosphatidylglycerol and with phosphatidic acid  Academic Article
• Effects of some isoprostanes on the human umbilical arteryin vitro  Academic Article
• Elastase-mediated fibrinogenolysis by chemoattractant-stimulated neutrophils occurs in the presence of physiologic concentrations of antiproteinases.  Academic Article
• Electrostatic Control of Phospholipid Polymorphism  Academic Article
• Enantioselective Synthesis of Planar Chiral Ferrocifens that Show Chiral Discrimination in Antiproliferative Activity on Breast Cancer Cells  Academic Article
• Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase  Academic Article
• Evaluation of peroxisome proliferator-activated receptor agonists on interleukin-5-induced eosinophil differentiation  Academic Article
• Evaluation of synthetic coumarins for antiausterity cytotoxicity against pancreatic cancers  Academic Article
• Evidence for Allosteric Linkage between Exosites 1 and 2 of Thrombin  Academic Article
• Excitatory and inhibitory actions of isoprostanes in human and canine airway smooth muscle.  Academic Article
• Factors Promoting Tamoxifen Resistance in Breast Cancer via Stimulating Breast Cancer Stem Cell Expansion  Academic Article
• Fluorescent probes of membrane surface properties  Academic Article
• Formation of a new stable phase of phosphatidylglycerols  Academic Article
• Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia  Academic Article
• From Bench to Bedside  Academic Article
• Functional Analysis of Disulfide Linkages Clustered within the Amino Terminus of Human Apolipoprotein B  Academic Article
• Functional Mapping of the Surface Residues of Human Thrombin  Academic Article
• Fundamentals of Endotoxin Structure and Function  Academic Article
• General method for the determination of precursor configuration in biosynthetic precursor-product relations. Derivation of pipecolic acid from D-lysine, and of piperidine alkaloids from L-lysine  Academic Article
• Genetic and biochemical studies with mutants of mammalian cells affected in microtubule-related proteins other than tubulin: mitochondrial localization of a microtubule-related protein  Academic Article
• Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model  Academic Article
• Genome duplication events have led to a diversification in the CPT I gene family in fish  Academic Article
• Green tea catechins evoke a phasic contraction in rat aorta via H2O2-mediated multiple-signalling pathways  Academic Article
• HPLC-purified 2-[125I]iodomelatonin labels multiple binding sites in hamster brain  Academic Article
• Heparin-induced thrombocytopenia.  Academic Article
• Histamine potentiation by hydroxylamines: structure-activity relations; inhibition of diamine oxidase  Academic Article
• Homocysteine-dependent Alterations in Mitochondrial Gene Expression, Function and Structure  Academic Article
• Homology Models of μ-Opioid Receptor with Organic and Inorganic Cations at Conserved Aspartates in the Second and Third Transmembrane Domains  Academic Article
• Homology Requirements for Ligation and Strand Exchange by the FLP Recombinase  Academic Article
• Host Defense Peptide LL-37, in Synergy with Inflammatory Mediator IL-1β, Augments Immune Responses by Multiple Pathways  Academic Article
• Human cell mutants affected in the interaction of the 12β-OH group of cardiac glycosides with the digitalis receptor  Academic Article
• Identification of 2-benzimidazolyl urea as a new antimitotic compound based on cross resistance studies with nocodazole resistant mutants of cho cells  Academic Article
• Identification of a Domain (155–183) on CD36 Implicated in the Phagocytosis of Apoptotic Neutrophils  Academic Article
• Identification of a GroES (CPN10)-related sequence motif in the GroEL (CPN60) chaperonins.  Academic Article
• Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity  Academic Article
• Identification of the Binding Site of Brucella VirB8 Interaction Inhibitors  Academic Article
• Identification of the Factor VIIa Binding Site on Tissue Factor by Homologous Loop Swap and Alanine Scanning Mutagenesis  Academic Article
• Impacts of Structural Photomodification on the Toxicity of Environmental Contaminants: Anthracene Photooxidation Products  Academic Article
• In vivo Effects of Low Molecular Weight Heparins on Experimental Thrombosis and Bleeding  Academic Article
• Incorporation of cell-adhesion peptides into collagen scaffolds promotes corneal epithelial stratification  Academic Article
• Increased sulphation improves the anticoagulant activities of heparan sulphate and dermatan sulphate  Academic Article
• Indolealkylamines and prolactin secretion a structure-activity study in the central nervous system of the rat  Academic Article
• Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition  Academic Article
• Influence of Cleavage Site on Global Folding of an RNA-Cleaving DNAzyme  Academic Article
• Inhibition by glucagon of the calcium pump in liver plasma membranes.  Academic Article
• Inhibition of adenosine kinase by phosphonate and bisphosphonate derivatives  Academic Article
• Inhibition of leucine aminopeptidase by amino acid hydroxamates.  Academic Article
• Inhibition of protein kinase C by cationic amphiphiles  Academic Article
• Interaction of the BK_Cachannel gating ring with dendrotoxins  Academic Article
• Interactions of corneal epithelial cells and surfaces modified with cell adhesion peptide combinations  Academic Article
• Interactions of drugs and toxins with permeant ions in potassium, sodium, and calcium channels.  Academic Article
• Intermolecular crosslinking of fatty acyl chains in phospholipids: use of photoactivable carbene precursors.  Academic Article
• Interspecies exchange mutagenesis of the first epidermal growth factor‐like domain of human factor VII  Academic Article
• Investigating serpin–enzyme complex formation and stability via single and multiple residue reactive centre loop substitutions in heparin cofactor II  Academic Article
• Investigation of aryl halides as ketone bioisosteres: Refinement of potent and selective inhibitors of human cytochrome P450 19A1 (aromatase)  Academic Article
• Ion occupancy of the channel pore is critical for triggering excitation-transcription (ET) coupling  Academic Article
• Isolation and characterization of insertion mutants in E1A of adenovirus type 5  Academic Article
• KvAP-Based Model of the Pore Region of Shaker Potassium Channel Is Consistent with Cadmium- and Ligand-Binding Experiments  Academic Article
• L-Leucinthiol — A potent inhibitor of leucine aminopeptidase  Academic Article
• Lanthionine−Somatostatin Analogs:  Synthesis, Characterization, Biological Activity, and Enzymatic Stability Studies  Academic Article
• Ligand action on sodium, potassium, and calcium channels: role of permeant ions  Academic Article
• Ligand interactions at the active site of aspartate transcarbamoylase from Escherichia coli  Academic Article
• Lipolytic and adenyl-cyclase-stimulating activity of glucagon1–6: comparison with glucagon derivatives chemically modified in the 7–29 sequence  Academic Article
• Liver fibrosis attributed to lipid lowering medications: two cases  Academic Article
• Membrane anchoring domain of herpes simplex virus glycoprotein gB is sufficient for nuclear envelope localization  Academic Article
• Metal-Induced Isomerization Yields an Intracellular Chelator that Disrupts Bacterial Iron Homeostasis  Academic Article
• Modularity of protein function: Chimeric interleukin 1.beta.s containing specific protease inhibitor loops retain function of both molecules  Academic Article
• Molecular Mapping of the Thrombin-Heparin Cofactor II Complex  Academic Article
• Molecular structural analysis of a novel and de-novo mutation in theSERPINC1gene associated with type 1 antithrombin deficiency  Academic Article
• Multiple sites and synergism in the binding of inhibitors to microsomal aminopeptidase  Academic Article
• Mutagenic reaction products of aqueous chlorination of catechol  Academic Article
• Mutants of CHO cells resistant to the protein synthesis inhibitors, cryptopleurine and tylocrebrine: genetic and biochemical evidence for common site of action of emetine, cryptopleurine, tylocrebrine, and tubulosine  Academic Article
• Mutants of HeLa cells resistant to ouabain and cassaine: Genetic evidence for the common site of action of cardiac glycosides and erythrophleum alkaloids  Academic Article
• Mutational analysis of Salmonella translocated effector members SifA and SopD2 reveals domains implicated in translocation, subcellular localization and function  Academic Article
• Mutational analysis of the vesicular stomatitis virus glycoprotein G for membrane fusion domains  Academic Article
• NMR Structures Reveal How Oxidation Inactivates Thrombomodulin  Academic Article
• Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis  Academic Article
• Nature’s Selection of Geranyl Group as a tRNA Modification: The Effects of Chain Length on Base-Pairing Specificity  Academic Article
• Non-sterol structural probes of the lanosterol 14α-demethylase from Saccharomyces cerevisiae  Academic Article
• Nonenzymatic Breakdown of the Tetrahedral (α-Carboxyketal Phosphate) Intermediates of MurA and AroA, Two Carboxyvinyl Transferases. Protonation of Different Functional Groups Controls the Rate and Fate of Breakdown  Academic Article
• Novel HldE-K Inhibitors Leading to Attenuated Gram Negative Bacterial Virulence  Academic Article
• One-pot, multicomponent synthesis of 2,3-disubstituted quinazolin-ones with potent and selective activity against Toxoplasma gondii  Academic Article
• Ordered surface carbons distinguish antifreeze proteins and their ice-binding regions  Academic Article
• Organometallic Antitumor Compounds: Ferrocifens as Precursors to Quinone Methides  Academic Article
• Overlapping Binding Sites of Structurally Different Antiarrhythmics Flecainide and Propafenone in the Subunit Interface of Potassium Channel Kv2.1*  Academic Article
• Palmitoyl-dl-Carnitine is a Multitarget Inhibitor of Pseudomonas aeruginosa Biofilm Development  Academic Article
• Penicillamine does not chelate gold (I).  Academic Article
• Penicillin's catalytic mechanism revealed by inelastic neutrons and quantum chemical theory  Academic Article
• Pharmacology of L-prolyl-L-leucyl-glycinamide (PLG): a review.  Academic Article
• Phenylalkylamines in calcium channels: computational analysis of experimental structures  Academic Article
• Phospholipid structure determines the effects of peptides on membranes. Differential scanning calorimetry studies with pentagastrin-related peptides  Academic Article
• Phospholipid vesicle aggregation induced by human myelin basic protein  Academic Article
• Phosphorus-containing inhibitors of aspartate transcarbamoylase fromEscherichia coli  Academic Article
• Phosphorylated Derivatives That Activate or Inhibit Mammalian Adenosine Kinase Provide Insights into the Role of Pentavalent Ions in AK Catalysis  Academic Article
• Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes  Academic Article
• Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross-resistance studies with various microtubule inhibitors and podophyllotoxin analogues.  Academic Article
• Position-Dependent Hydrophobicity of the Antimicrobial Magainin Peptide Affects the Mode of Peptide−Lipid Interactions and Selective Toxicity  Academic Article
• Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs  Academic Article
• Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives  Academic Article
• Preclinical differentiation of low molecular weight heparins.  Academic Article
• Predicting the reactivity of ambidentate nucleophiles and electrophiles using a single, general-purpose, reactivity indicator  Academic Article
• Preparation and Evaluation of Carborane Analogues of Tamoxifen  Academic Article
• Preparation and characterization of alkylated poly(vinyl alcohol) hydrogels using alkyl halides  Academic Article
• Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors  Academic Article
• Presence of an amphipathic helical segment and its relationship to biological potency of calcitonin analogs  Academic Article
• Primary structure-based function characterization of BRCT domain replicates in BRCA1  Academic Article
• Probing the "active site" of diamine oxidase: structure-activity relations for histamine potentiation by O-alkylhydroxylamines on colonic epithelium.  Academic Article
• Processing of the Papain Precursor  Academic Article
• Promotion of hexagonal phase formation and lipid mixing by fatty acids with varying degrees of unsaturation  Academic Article
• Protein adsorption to polyethylene glycol modified liposomes from fibrinogen solution and from plasma  Academic Article
• Quantification of liver capillary permeability using a macromolecular contrast agent for magnetic resonance imaging  Academic Article
• Rationale Behind the Development of Low Molecular Weight Heparin Derivatives  Academic Article
• Receptors and signaling pathway underlying relaxations to isoprostanes in canine and porcine airway smooth muscle  Academic Article
• Recognition of Anionic Porphyrins by DNA Aptamers  Academic Article
• Regulation of CTP:  Phosphocholine Cytidylyltransferase Activity by the Physical Properties of Lipid Membranes:  An Important Role for Stored Curvature Strain Energy  Academic Article
• Regulation of HCN Ion Channels by Non-canonical Cyclic Nucleotides  Book
• Repellent Signaling by Slit Requires the Leucine-Rich Repeats  Academic Article
• Requirement of Lysine Residues Outside of the Proposed Pentasaccharide Binding Region for High Affinity Heparin Binding and Activation of Human Antithrombin III  Academic Article
• Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr  Academic Article
• Role of Membrane Defects in the Regulation of the Activity of Protein Kinase C  Academic Article
• Role of aromatic substituents on the antiproliferative effects of diphenyl ferrocenyl butene compounds  Academic Article
• Role of peptide structure in lipid-peptide interactions: a fluorescence study of the binding of pentagastrin-related pentapeptides to phospholipid vesicles  Academic Article
• Role of peptide structure in lipid-peptide interactions: high-sensitivity differential scanning calorimetry and electron spin resonance studies of the structural properties of dimyristoylphosphatidylcholine membranes interacting with pentagastrin-related pentapeptides  Academic Article
• Role of the position of unsaturation on the phase behavior and intrinsic curvature of phosphatidylethanolamines  Academic Article
• Selective suppression of rapid eye movement sleep (REMS) in cats by typical and atypical antidepressants.  Academic Article
• Sendai virus N-terminal fusion peptide consists of two similar repeats, both of which contribute to membrane fusion  Academic Article
• Sequence-function relationships provide new insight into the cleavage site selectivity of the 8-17 RNA-cleaving deoxyribozyme  Academic Article
• Shortened cytoplasmic domain affects intracellular transport but not nuclear localization of a viral glycoprotein.  Academic Article
• Signal Transduction within G-protein Coupled Receptors via an Ion Tunnel: A Hypothesis  Academic Article
• Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor  Academic Article
• Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling  Academic Article
• Small-Molecule Modulators of Listeria monocytogenes Biofilm Development  Academic Article
• Specificity of Membrane Binding of the Neuronal Protein NAP-22  Academic Article
• Strategies for development of novel antithrombotics: modulating thrombin's procoagulant and anticoagulant properties  Academic Article
• Streptogramins, Oxazolidinones, and Other Inhibitors of Bacterial Protein Synthesis  Academic Article
• Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria  Academic Article
• Structural Model for Dihydropyridine Binding to L-type Calcium Channels  Academic Article
• Structural Model for Phenylalkylamine Binding to L-type Calcium Channels  Academic Article
• Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4  Academic Article
• Structural and Functional Properties of an Unusual Internal Fusion Peptide in a Nonenveloped Virus Membrane Fusion Protein  Academic Article
• Structural and Kinetic Characterization of the LPS Biosynthetic Enzyme d-α,β-d-Heptose-1,7-bisphosphate Phosphatase (GmhB) from Escherichia coli,  Academic Article
• Structural determinants of the interactions of catechins with Aβ oligomers and lipid membranes  Academic Article
• Structural determinants responsible for the biological activity of (-)-emetine, (-)-cryptopleurine, and (-)-tylocrebrine: structure-activity relationship among related compounds.  Academic Article
• Structural requirements for glucagon receptor binding and activation of adenylate cyclase in liver. Study of chemically modified forms of the hormone, including N alpha-trinitrophenyl glucagon, an antagonist.  Academic Article
• Structural requirements for specific inhibition of microsomal aminopeptidase by mercaptoamines  Academic Article
• Structural–Functional Studies of Burkholderia cenocepacia d-Glycero-β-d-manno-heptose 7-Phosphate Kinase (HldA) and Characterization of Inhibitors with Antibiotic Adjuvant and Antivirulence Properties  Academic Article
• Structure  Academic Article
• Structure Activity Studies on the Crinane Alkaloid Apoptosis-inducing Pharmacophore  Academic Article
• Structure and Composition of the Fusion Pore  Academic Article
• Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme  Academic Article
• Structure and Mechanism of the Lincosamide Antibiotic Adenylyltransferase LinB  Academic Article
• Structure and function of aspartate transcarbamoylase studied using chymotrypsin as a probe  Academic Article
• Structure-Activity Studies on Mammalian Adenosine Kinase  Academic Article
• Structure-Function Relationship in a Winter Flounder Antifreeze Polypeptide  Academic Article
• Structure-Function Relationships in a Winter Flounder Antifreeze Polypeptide  Academic Article
• Structure-activity studies on N -Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation  Academic Article
• Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells  Academic Article
• Structure-activity study and design of multidrug-resistant reversal compounds by a computer automated structure evaluation methodology.  Academic Article
• Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance  Academic Article
• Structures of shorthorn sculpin antifreeze polypeptides  Academic Article
• Structure–Function Relationships of Human Milk Oligosaccharides on the Intestinal Epithelial Transcriptome in Caco‐2 Cells and a Murine Model of Necrotizing Enterocolitis  Academic Article
• Structure–activity studies of echinomycin antibiotics against drug-resistant and biofilm-forming Staphylococcus aureus and Enterococcus faecalis  Academic Article
• Structure–activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids  Academic Article
• Structure–activity studies on seco-pancratistatin analogs: Potent inhibitors of human cytochrome P450 3A4  Academic Article
• Structure–function studies on Hsp47: pH-dependent inhibition of collagen fibril formation in vitro  Academic Article
• Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore  Academic Article
• Studies on chemically modified forms of the myelin basic protein: Requirements for encephalitogenicity  Academic Article
• Synergistic effect of purine derivatives on the toxicity of pyrazofurin and 6-azauridine towards cultured mammalian cells  Academic Article
• Synthesis and Dopamine Receptor Modulating Activity of 3-Substituted γ-Lactam Peptidomimetics of l-Prolyl-l-leucyl-glycinamide  Academic Article
• Synthesis and Dopamine Receptor Modulating Activity of Substituted Bicyclic Thiazolidine Lactam Peptidomimetics of l-Prolyl-l-leucyl-glycinamide  Academic Article
• Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation  Academic Article
• Synthesis and Properties of Carborane-Functionalized Aliphatic Polyester Dendrimers  Academic Article
• Synthesis and Screening of Mono- and Di-Aryl Technetium and Rhenium Metallocarboranes. A New Class of Probes for the Estrogen Receptor  Academic Article
• Synthesis and Screening of a Library of Re/Tc-Based Amyloid Probes Derived from β-Breaker Peptides  Academic Article
• Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide  Academic Article
• Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases  Academic Article
• Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives  Academic Article
• Synthesis and biological characterisation of a series of iberiotoxin analogues  Academic Article
• Synthesis and biological evaluation of analogs of Pro-Leu-Gly-NH2 modified at the leucyl residue  Academic Article
• Synthesis and dopamine receptor modulating activity of lactam conformationally constrained analogs of Pro-Leu-Gly-NH2  Academic Article
• Synthesis and evaluation of new salicylaldehyde-2-picolinylhydrazone Schiff base compounds of Ru(II), Rh(III) and Ir(III) as in vitro antitumor, antibacterial and fluorescence imaging agents  Academic Article
• Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (β-Lactones)  Academic Article
• Synthesis and structure-activity relationships among glycosidic derivatives of 4'-demethylepipodophyllotoxin and epipodophyllotoxin, showing VM26- and VP16-213-like activities.  Academic Article
• Synthesis of Boroxifen, A Nido-Carborane Analogue of Tamoxifen  Academic Article
• Synthesis of Pro-Leu-Gly-NH2 analogs modified at the prolyl residue and evaluation of their effects on the receptor binding activity of the central dopamine receptor agonist, ADTN  Academic Article
• Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies  Academic Article
• Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii  Academic Article
• Synthesis of α-methylstilbenes using an aqueous Wittig methodology and application toward the development of potent human aromatase inhibitors  Academic Article
• The 5' flanking sequence negatively modulates the in vivo expression and in vitro transcription of a human tRNA gene  Academic Article
• The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor  Academic Article
• The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents  Academic Article
• The Auto-Inhibitory Role of the EPAC Hinge Helix as Mapped by NMR  Academic Article
• The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2  Academic Article
• The Large Cytoplasmic Domain Is Not Required for Concentration of N-CAM at Cell-Cell Contacts in Transfected Mouse Neuroblastoma Cells  Academic Article
• The M358R variant of α 1 -proteinase inhibitor inhibits coagulation factor VIIa  Academic Article
• The Pattern of Amino Acid Replacements in α/β-Barrels  Academic Article
• The Polar Region Consecutive to the HIV Fusion Peptide Participates in Membrane Fusion  Academic Article
• The Reduction of Hydroxypyruvate by Human Serum  Academic Article
• The Solution Conformational Features of Two Highly Homologous Antigenic Peptides of Foot-and-mouth Disease Virus Serotype A, Variants A and USA, Correlate with their Serological Properties  Academic Article
• The Structural Diversity of Deoxyribozymes  Academic Article
• The Structural Integrity of Anion Binding Exosite I of Thrombin Is Required and Sufficient for Timely Cleavage and Activation of Factor V and Factor VIII  Academic Article
• The Transferable Tail:  Fusion of the N-Terminal Acidic Extension of Heparin Cofactor II to α₁-Proteinase Inhibitor M358R Specifically Increases the Rate of Thrombin Inhibition  Academic Article
• The antimicrobial peptide trichogin and its interaction with phospholipid membranes  Academic Article
• The dependence of the lipolytic activity of Rhizopus arrhizus lipase on surfactant concentration in Aerosol-OT/isooctane reverse micelles and its relationship to enzyme structure  Academic Article
• The effect of cholesterol on the interaction of glucagon with the gel state of dimyristoylphosphatidylcholine  Academic Article
• The effect of free fatty acids on the thermotropic phase transition of dimyristoyl glycerophosphocholine  Academic Article
• The effects of low molecular weight and standard heparin on calcium loss from fetal rat calvaria  Academic Article
• The effects of membrane physical properties on the fusion of Sendai virus with human erythrocyte ghosts and liposomes. Analysis of kinetics and extent of fusion.  Academic Article
• The essential role of the imidazole group of glucagon in its biological function  Academic Article
• The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells  Academic Article
• The p56 -interacting Protein p62 Stimulates Transcription via the SV40 Enhancer  Academic Article
• The relevance of the structure of lysine bound to Sepharose for the affinity of rabbit plasminogen  Academic Article
• The role of hydroxyproline in collagen folding: Conformational energy calculations on oligopeptides containing proline and hydroxyproline  Academic Article
• The role of nonspecific hydrophobic interactions in the biological activity of N epsilon-acyl derivatives of glucagon. Studies of conformation, receptor binding, and adenylate cyclase activation.  Academic Article
• Theoretical study of interaction of winter flounder antifreeze protein with ice  Academic Article
• Thiopeptides: antibiotics with unique chemical structures and diverse biological activities  Academic Article
• Thrombin Inhibition by Hirudin: How Hirudin Inhibits Thrombin  Academic Article
• Thrombin structure and function  Academic Article
• Total Synthesis and Activity of the Metallo-β-lactamase Inhibitor Aspergillomarasmine A  Academic Article
• Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure-Activity Relationships  Academic Article
• Towards a structure-function analysis of bovine lactoferricin and related tryptophan- and arginine-containing peptides  Conference Paper
• Transformation of Pro-Leu-Gly-NH₂ Peptidomimetic Positive Allosteric Modulators of the Dopamine D₂ Receptor into Negative Modulators  Academic Article
• Trichogin: a paradigm for lipopeptaibols  Academic Article
• Virus replication inhibitory peptide inhibits the conversion of phospholipid bilayers to the hexagonal phase  Academic Article
• [Conformation of 1,3-bis(p-chlorobenzylidene amino)guanidine (chimcoccide) and its interaction with calcium ions].  Academic Article
• [Distance between the ammonium groups of polymethylene bistrimethyl-ammonium compounds based on theoretical conformational analysis data].  Academic Article
• [Molecular physiology of adrenoreceptors].  Academic Article
• [Predisposition of the optimal conformations of adrenergic compounds to the formation of polydentate complexes with metal ions].  Academic Article
• [Simulation of DNA conformation possibilities by means of nonbonded interaction energy calculations of complementary dinucleoside phosphate complexes].  Academic Article
• [Use of theoretical conformational analysis for solving the problem of the relationship between structure and action of cholinergic blockaders (difasil and amizil)].  Academic Article
• d-penicillamine: Chemistry and clinical use in rheumatic disease  Academic Article
• iso-Lactam and reduced amide analogues of the peptidomimetic dopamine receptor modulator 3(R)-[(2(S)-Pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide  Academic Article
• von Willebrand Factor: Form for Function  Academic Article