Structure-Activity Relationship
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.beta.-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22 Academic Article
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1,4-Dihydropyridine Scaffold in Medicinal Chemistry, The Story so Far And Perspectives (Part 1): Action in Ion Channels and GPCRs Academic Article
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2 Mechanisms of action of low molecular weight heparins and heparinoids Academic Article
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2-[125I]Iodomelatonin binding sites in the quail heart: Characteristics, distribution and modulation by guanine nucleotides and cations Academic Article
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3D organization and function of the cell: Golgi budding and vesicle biogenesis to docking at the porosome complex Academic Article
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4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction Academic Article
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A 2.13 Å Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region Academic Article
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A 23bp Insertion in the Endothelial Protein C Receptor (EPCR) Gene Impairs EPCR Function Academic Article
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A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using 99mTc- and 177Lu-Labeled Tetrazines Academic Article
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A Highly Dynamic Loop of the Pseudomonas aeruginosa PA14 Type IV Pilin Is Essential for Pilus Assembly Academic Article
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A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor Academic Article
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A Refined Model for the Somatostatin Pharmacophore: Conformational Analysis of Lanthionine−Sandostatin Analogs Academic Article
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A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome Academic Article
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A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection Academic Article
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A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase Academic Article
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A comprehensive study of genic variation in natural populations of Drosophila melanogaster. V. Structural–functional constraints on protein molecules and enzymes and the levels and patterns of variation among genes Academic Article
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A densitometric study of the effects of free fatty acids on the phase transition of dimyristoylphosphatidylcholine bilayers Academic Article
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A fast and sensitive method for the analysis of modified nucleosides in tRNA Academic Article
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A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both α- and β-ketone reduction during chain growth Academic Article
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A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function Academic Article
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A proposal: That the heterogeneity of glycoprotein N-glycans is a feature of their biosynthesis and may be of functional significance Academic Article
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A recurrent de novo HSPD1 variant is associated with hypomyelinating leukodystrophy Academic Article
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Action of insulin in rat adipocytes and membrane properties Academic Article
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Aliphatic aldehydes promote myelin basic protein-induced fusion of phospholipid vesicles Academic Article
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Allosteric Modulation of the Dopamine D2 Receptor by Pro-Leu-Gly-NH2 Peptidomimetics Constrained in Either a Polyproline II Helix or a Type II β-Turn Conformation Academic Article
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Altering Heparin Cofactor II at VAL439 (P6) either Impairs Inhibition of Thrombin or Confers Elastase Resistance Academic Article
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Amino acid substitutions of the P2 residue of human antithrombin that either enhance or impair function Academic Article
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Aminorifamycins and Sporalactams Produced in Culture by a Micromonospora sp. Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics Academic Article
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An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria Academic Article
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Antagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues Academic Article
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Antibiotics as probes of biological complexity Academic Article
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Antibodies to Catecholamines Academic Article
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Antibodies to Indolealkylamines; Serotonin and Melatonin Academic Article
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Antimitotic activity of structurally simplified biaryl analogs of the anticancer agents colchicine and combretastatin A4 Academic Article
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Antineoplastic Agents 491.1 Synthetic Conversion of Aaptamine to Isoaaptamine, 9-Demethylaaptamine, and 4-Methylaaptamine Academic Article
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Aortic smooth muscle and endothelial plasma membrane Ca2+pump isoforms are inhibited differently by the extracellular inhibitor caloxin 1b1 Academic Article
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Application of Combinatorial Libraries and Protein Engineering to the Discovery of Novel Anti-Thrombotic Drugs Conference Paper
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Architecture of the Neuronal Nicotinic Acetylcholine Receptor Ion Channel at the Binding Site of bis-Ammonium Blockers Academic Article
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Are the pharmacological effects of L-prolyl-L-leucylglycinamide (PLG) mediated through specific receptor mechanisms? Academic Article
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Arginine Methylation Regulates Telomere Length and Stability Academic Article
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Arginine-lysine positional swap of the LL-37 peptides reveals evolutional advantages of the native sequence and leads to bacterial probes Academic Article
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Bacterial Membranes as Predictors of Antimicrobial Potency Academic Article
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Basis for Selectivity of Cationic Antimicrobial Peptides for Bacterial Versus Mammalian Membranes Academic Article
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Bicyclic thiazolidine lactam peptidomimetics of the dopamine receptor modulating peptide Pro-Leu-Gly-NH2 Academic Article
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Bimolecular Hydrogen Abstraction from Phenols by Aromatic Ketone Triplets† Academic Article
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Bioactive paper dipstick sensors for acetylcholinesterase inhibitors based on sol–gel/enzyme/gold nanoparticle composites Academic Article
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Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window” Academic Article
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Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor Academic Article
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Biological activity of metabolites of PGD2 on canine proximal colon Academic Article
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Biologically active calcitonin analogs which have minimal interactions with phospholipids Academic Article
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Biologically potent analogues of salmon calcitonin which do not contain an N-terminal disulfide-bridged ring structure Academic Article
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Biosynthesis of Vitamin B6. Incorporation of Terminally Labelled Glucose Academic Article
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Biosynthetic utilization of photoreactive fatty acids by rat liver microsomes Academic Article
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Broad and Differential Animal Angiotensin-Converting Enzyme 2 Receptor Usage by SARS-CoV-2 Academic Article
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Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes Academic Article
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Ca2+-dependent Antifreeze Proteins Academic Article
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Capping DNA with DNA Academic Article
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Carbapenems and Lipid Bilayers: Localization, Partitioning, and Energetics Academic Article
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Cationic Liposomes for Direct Gene Transfer in Therapy of Cancer and Other Diseases Academic Article
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Cephalosporin-induced hypoprothrombinemia: is the N-methylthiotetrazole side chain the culprit? Academic Article
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Ceragenins (Cationic Steroid Compounds), a novel class of antimicrobial agents Academic Article
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Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73 Academic Article
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Characterization and Biologic Activities of Recombinant Rat Soluble Interleukin-6 Receptor Academic Article
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Characterization of a Distinctive Motif of the Low Molecular Weight Neurotrophin Receptor that Modulates NGF-mediated Neurite Growth Academic Article
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Characterization of the putative fusogenic domain in vesicular stomatitis virus glycoprotein G Academic Article
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Chloride Channels of Glycine and GABA Receptors with Blockers: Monte Carlo Minimization and Structure-Activity Relationships Academic Article
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Circular dichroism (CD) studies of antagonists derived from parathyroid hormone-related protein Academic Article
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Cold Stress Makes Escherichia coli Susceptible to Glycopeptide Antibiotics by Altering Outer Membrane Integrity Academic Article
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Comparative biochemistry of cytochrome c oxidase in animals Academic Article
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Comparison of Heparin- and Dermatan Sulfate-mediated Catalysis of Thrombin Inactivation by Heparin Cofactor II Academic Article
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Conformation of a synthetic hexapeptide substrate of collagen lysyl hydroxylase Academic Article
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Conformational Analysis of the Ca2+-Bound Opioid Peptides: Implications for Ligand-Receptor Interaction Academic Article
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Conformational and biological properties of glucagon fragments containing residues 1-17 and 19-29 Academic Article
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Conformational determinants in receptor recognition of peptide hormones: interaction of parathyroid hormone with the glucagon receptor Academic Article
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Conformational studies on analogs of recombinant parathyroid hormone and Academic Article
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Cooperativity of papain-substrate interaction energies in the S2 to S2' subsites Academic Article
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Cross-chimeric analysis of selectivity of secretin and VPAC(1) receptor activation. Academic Article
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Crystal Structure of a Ca2+-discharged Photoprotein Academic Article
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Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases Academic Article
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Cytochrome P450 3A4 Inhibitory Activity Studies within the Lycorine series of Alkaloids Academic Article
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Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape Academic Article
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Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA Academic Article
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Deletion sequences of salmon calcitonin that retain the essential biological and conformational features of the intact molecule Academic Article
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Design and Characterization of a Broad -Spectrum Bactericidal Acyl-lysyl Oligomer Academic Article
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Design and Synthesis of Photoaffinity-Labeling Ligands of the l-Prolyl-l-leucylglycinamide Binding Site Involved in the Allosteric Modulation of the Dopamine Receptor Academic Article
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Design and synthesis of [ 125 I]Pyricoxib: A novel 125 I-labeled cyclooxygenase-2 (COX-2) inhibitors Academic Article
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Design of Novel Rho Kinase Inhibitors Using Energy Based Pharmacophore Modeling, Shape-Based Screening, in Silico Virtual Screening, and Biological Evaluation Academic Article
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Design, Synthesis, and Dopamine Receptor Modulating Activity of Spiro Bicyclic Peptidomimetics of l-Prolyl-l-leucyl-glycinamide Academic Article
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Development of a specific assay for cardiac glycoside-like compounds based on cross-resistance of human cell mutants Academic Article
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Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents Academic Article
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Dimensions of the ion channel in neuronal nicotinic acetylcholine receptor as estimated from analysis of conformation-activity relationships of open-channel blocking drugs Academic Article
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Dimerization of the P-glycoprotein in membranes Academic Article
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Dinucleotide Junction Cleavage Versatility of 8-17 Deoxyribozyme Academic Article
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Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein. Academic Article
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Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma Academic Article
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Discovery of a Novel Series of Tricyclic Oxadiazine 4a-Methyl Esters Based on Indoxacarb as Potential Sodium Channel Blocker/Modulator Insecticides Academic Article
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Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1) Academic Article
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Discovery of a novel class of aldol-derived 1,2,3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase) Academic Article
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Discovery of potent antiviral (HSV-1) quinazolinones and initial structure-activity relationship studies Academic Article
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Divergent structural requirements exist for calcitonin receptor binding specificity and adenylate cyclase activation. Academic Article
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Dopamine receptor modulation by Pro-Leu-Gly-NH2 analogs possessing cyclic amino acid residues at the C-terminal position Academic Article
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Dopamine receptor modulation by conformationally constrained analogs of Pro-Leu-Gly-NH2 Academic Article
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Down-regulation of haloperidol-induced striatal dopamine receptor supersensitivity by active analogues of L-prolyl-L-leucyl-glycinamide (PLG) Academic Article
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Drug evaluation: AP-23573--an mTOR inhibitor for the treatment of cancer. Academic Article
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Drug evaluation: E-5564. Academic Article
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EFFECTS OF TETRANDRINE AND CLOSELY RELATED BIS-BENZYLISOQUINOLINE DERIVATIVES ON CYTOSOLIC Ca2+IN HUMAN LEUKAEMIC HL-60 CELLS: A STRUCTURE-ACTIVITY RELATIONSHIP STUDY Academic Article
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Effect of Lipid Structure on the Capacity of Myelin Basic Protein to Alter Vesicle Properties: Potent Effects of Aliphatic Aldehydes in Promoting Basic Protein-Induced Vesicle Aggregation Academic Article
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Effect of magainin, class L, and class A amphipathic peptides on fatty acid spin labels in lipid bilayers Academic Article
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Effect of microheterogeneity on the structure and function of the myelin basic protein Academic Article
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Effect of specific trinitrophenylation of the lysine epsilon amino group of glucagon on receptor binding and adenylate cyclase activation Academic Article
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Effects of heparin, its low molecular weight fractions and other glycosaminoglycans on thrombus growth Academic Article
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Effects of lipid structure on peptide-lipid interactions complexes of salmon calcitonin with phosphatidylglycerol and with phosphatidic acid Academic Article
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Effects of some isoprostanes on the human umbilical arteryin vitro Academic Article
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Elastase-mediated fibrinogenolysis by chemoattractant-stimulated neutrophils occurs in the presence of physiologic concentrations of antiproteinases. Academic Article
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Electrostatic Control of Phospholipid Polymorphism Academic Article
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Enantioselective Synthesis of Planar Chiral Ferrocifens that Show Chiral Discrimination in Antiproliferative Activity on Breast Cancer Cells Academic Article
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Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase Academic Article
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Evaluation of peroxisome proliferator-activated receptor agonists on interleukin-5-induced eosinophil differentiation Academic Article
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Evaluation of synthetic coumarins for antiausterity cytotoxicity against pancreatic cancers Academic Article
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Evidence for Allosteric Linkage between Exosites 1 and 2 of Thrombin Academic Article
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Excitatory and inhibitory actions of isoprostanes in human and canine airway smooth muscle. Academic Article
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Factors Promoting Tamoxifen Resistance in Breast Cancer via Stimulating Breast Cancer Stem Cell Expansion Academic Article
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Fluorescent probes of membrane surface properties Academic Article
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Formation of a new stable phase of phosphatidylglycerols Academic Article
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Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia Academic Article
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From Bench to Bedside Academic Article
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Functional Analysis of Disulfide Linkages Clustered within the Amino Terminus of Human Apolipoprotein B Academic Article
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Functional Mapping of the Surface Residues of Human Thrombin Academic Article
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Fundamentals of Endotoxin Structure and Function Academic Article
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General method for the determination of precursor configuration in biosynthetic precursor-product relations. Derivation of pipecolic acid from D-lysine, and of piperidine alkaloids from L-lysine Academic Article
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Genetic and biochemical studies with mutants of mammalian cells affected in microtubule-related proteins other than tubulin: mitochondrial localization of a microtubule-related protein Academic Article
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Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model Academic Article
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Genome duplication events have led to a diversification in the CPT I gene family in fish Academic Article
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Green tea catechins evoke a phasic contraction in rat aorta via H2O2-mediated multiple-signalling pathways Academic Article
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HPLC-purified 2-[125I]iodomelatonin labels multiple binding sites in hamster brain Academic Article
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Heparin-induced thrombocytopenia. Academic Article
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Histamine potentiation by hydroxylamines: structure-activity relations; inhibition of diamine oxidase Academic Article
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Homocysteine-dependent Alterations in Mitochondrial Gene Expression, Function and Structure Academic Article
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Homology Models of μ-Opioid Receptor with Organic and Inorganic Cations at Conserved Aspartates in the Second and Third Transmembrane Domains Academic Article
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Homology Requirements for Ligation and Strand Exchange by the FLP Recombinase Academic Article
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Host Defense Peptide LL-37, in Synergy with Inflammatory Mediator IL-1β, Augments Immune Responses by Multiple Pathways Academic Article
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Human cell mutants affected in the interaction of the 12β-OH group of cardiac glycosides with the digitalis receptor Academic Article
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Identification of 2-benzimidazolyl urea as a new antimitotic compound based on cross resistance studies with nocodazole resistant mutants of cho cells Academic Article
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Identification of a Domain (155–183) on CD36 Implicated in the Phagocytosis of Apoptotic Neutrophils Academic Article
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Identification of a GroES (CPN10)-related sequence motif in the GroEL (CPN60) chaperonins. Academic Article
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Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity Academic Article
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Identification of the Binding Site of Brucella VirB8 Interaction Inhibitors Academic Article
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Identification of the Factor VIIa Binding Site on Tissue Factor by Homologous Loop Swap and Alanine Scanning Mutagenesis Academic Article
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Impacts of Structural Photomodification on the Toxicity of Environmental Contaminants: Anthracene Photooxidation Products Academic Article
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In vivo Effects of Low Molecular Weight Heparins on Experimental Thrombosis and Bleeding Academic Article
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Incorporation of cell-adhesion peptides into collagen scaffolds promotes corneal epithelial stratification Academic Article
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Increased sulphation improves the anticoagulant activities of heparan sulphate and dermatan sulphate Academic Article
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Indolealkylamines and prolactin secretion a structure-activity study in the central nervous system of the rat Academic Article
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Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition Academic Article
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Influence of Cleavage Site on Global Folding of an RNA-Cleaving DNAzyme Academic Article
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Inhibition by glucagon of the calcium pump in liver plasma membranes. Academic Article
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Inhibition of adenosine kinase by phosphonate and bisphosphonate derivatives Academic Article
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Inhibition of leucine aminopeptidase by amino acid hydroxamates. Academic Article
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Inhibition of protein kinase C by cationic amphiphiles Academic Article
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Interaction of the BKCachannel gating ring with dendrotoxins Academic Article
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Interactions of corneal epithelial cells and surfaces modified with cell adhesion peptide combinations Academic Article
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Interactions of drugs and toxins with permeant ions in potassium, sodium, and calcium channels. Academic Article
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Intermolecular crosslinking of fatty acyl chains in phospholipids: use of photoactivable carbene precursors. Academic Article
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Interspecies exchange mutagenesis of the first epidermal growth factor‐like domain of human factor VII Academic Article
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Investigating serpin–enzyme complex formation and stability via single and multiple residue reactive centre loop substitutions in heparin cofactor II Academic Article
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Investigation of aryl halides as ketone bioisosteres: Refinement of potent and selective inhibitors of human cytochrome P450 19A1 (aromatase) Academic Article
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Ion occupancy of the channel pore is critical for triggering excitation-transcription (ET) coupling Academic Article
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Isolation and characterization of insertion mutants in E1A of adenovirus type 5 Academic Article
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KvAP-Based Model of the Pore Region of Shaker Potassium Channel Is Consistent with Cadmium- and Ligand-Binding Experiments Academic Article
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L-Leucinthiol — A potent inhibitor of leucine aminopeptidase Academic Article
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Lanthionine−Somatostatin Analogs: Synthesis, Characterization, Biological Activity, and Enzymatic Stability Studies Academic Article
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Ligand action on sodium, potassium, and calcium channels: role of permeant ions Academic Article
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Ligand interactions at the active site of aspartate transcarbamoylase from Escherichia coli Academic Article
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Lipolytic and adenyl-cyclase-stimulating activity of glucagon1–6: comparison with glucagon derivatives chemically modified in the 7–29 sequence Academic Article
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Liver fibrosis attributed to lipid lowering medications: two cases Academic Article
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Membrane anchoring domain of herpes simplex virus glycoprotein gB is sufficient for nuclear envelope localization Academic Article
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Metal-Induced Isomerization Yields an Intracellular Chelator that Disrupts Bacterial Iron Homeostasis Academic Article
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Modularity of protein function: Chimeric interleukin 1.beta.s containing specific protease inhibitor loops retain function of both molecules Academic Article
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Molecular Mapping of the Thrombin-Heparin Cofactor II Complex Academic Article
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Molecular structural analysis of a novel and de-novo mutation in theSERPINC1gene associated with type 1 antithrombin deficiency Academic Article
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Multiple sites and synergism in the binding of inhibitors to microsomal aminopeptidase Academic Article
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Mutagenic reaction products of aqueous chlorination of catechol Academic Article
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Mutants of CHO cells resistant to the protein synthesis inhibitors, cryptopleurine and tylocrebrine: genetic and biochemical evidence for common site of action of emetine, cryptopleurine, tylocrebrine, and tubulosine Academic Article
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Mutants of HeLa cells resistant to ouabain and cassaine: Genetic evidence for the common site of action of cardiac glycosides and erythrophleum alkaloids Academic Article
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Mutational analysis of Salmonella translocated effector members SifA and SopD2 reveals domains implicated in translocation, subcellular localization and function Academic Article
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Mutational analysis of the vesicular stomatitis virus glycoprotein G for membrane fusion domains Academic Article
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NMR Structures Reveal How Oxidation Inactivates Thrombomodulin Academic Article
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Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis Academic Article
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Nature’s Selection of Geranyl Group as a tRNA Modification: The Effects of Chain Length on Base-Pairing Specificity Academic Article
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Non-sterol structural probes of the lanosterol 14α-demethylase from Saccharomyces cerevisiae Academic Article
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Nonenzymatic Breakdown of the Tetrahedral (α-Carboxyketal Phosphate) Intermediates of MurA and AroA, Two Carboxyvinyl Transferases. Protonation of Different Functional Groups Controls the Rate and Fate of Breakdown Academic Article
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Novel HldE-K Inhibitors Leading to Attenuated Gram Negative Bacterial Virulence Academic Article
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One-pot, multicomponent synthesis of 2,3-disubstituted quinazolin-ones with potent and selective activity against Toxoplasma gondii Academic Article
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Ordered surface carbons distinguish antifreeze proteins and their ice-binding regions Academic Article
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Organometallic Antitumor Compounds: Ferrocifens as Precursors to Quinone Methides Academic Article
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Overlapping Binding Sites of Structurally Different Antiarrhythmics Flecainide and Propafenone in the Subunit Interface of Potassium Channel Kv2.1* Academic Article
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Palmitoyl-dl-Carnitine is a Multitarget Inhibitor of Pseudomonas aeruginosa Biofilm Development Academic Article
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Penicillamine does not chelate gold (I). Academic Article
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Penicillin's catalytic mechanism revealed by inelastic neutrons and quantum chemical theory Academic Article
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Pharmacology of L-prolyl-L-leucyl-glycinamide (PLG): a review. Academic Article
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Phenylalkylamines in calcium channels: computational analysis of experimental structures Academic Article
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Phospholipid structure determines the effects of peptides on membranes. Differential scanning calorimetry studies with pentagastrin-related peptides Academic Article
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Phospholipid vesicle aggregation induced by human myelin basic protein Academic Article
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Phosphorus-containing inhibitors of aspartate transcarbamoylase fromEscherichia coli Academic Article
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Phosphorylated Derivatives That Activate or Inhibit Mammalian Adenosine Kinase Provide Insights into the Role of Pentavalent Ions in AK Catalysis Academic Article
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Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes Academic Article
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Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross-resistance studies with various microtubule inhibitors and podophyllotoxin analogues. Academic Article
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Position-Dependent Hydrophobicity of the Antimicrobial Magainin Peptide Affects the Mode of Peptide−Lipid Interactions and Selective Toxicity Academic Article
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Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs Academic Article
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Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives Academic Article
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Preclinical differentiation of low molecular weight heparins. Academic Article
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Predicting the reactivity of ambidentate nucleophiles and electrophiles using a single, general-purpose, reactivity indicator Academic Article
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Preparation and Evaluation of Carborane Analogues of Tamoxifen Academic Article
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Preparation and characterization of alkylated poly(vinyl alcohol) hydrogels using alkyl halides Academic Article
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Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors Academic Article
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Presence of an amphipathic helical segment and its relationship to biological potency of calcitonin analogs Academic Article
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Primary structure-based function characterization of BRCT domain replicates in BRCA1 Academic Article
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Probing the "active site" of diamine oxidase: structure-activity relations for histamine potentiation by O-alkylhydroxylamines on colonic epithelium. Academic Article
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Processing of the Papain Precursor Academic Article
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Promotion of hexagonal phase formation and lipid mixing by fatty acids with varying degrees of unsaturation Academic Article
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Protein adsorption to polyethylene glycol modified liposomes from fibrinogen solution and from plasma Academic Article
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Quantification of liver capillary permeability using a macromolecular contrast agent for magnetic resonance imaging Academic Article
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Rationale Behind the Development of Low Molecular Weight Heparin Derivatives Academic Article
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Receptors and signaling pathway underlying relaxations to isoprostanes in canine and porcine airway smooth muscle Academic Article
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Recognition of Anionic Porphyrins by DNA Aptamers Academic Article
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Regulation of CTP: Phosphocholine Cytidylyltransferase Activity by the Physical Properties of Lipid Membranes: An Important Role for Stored Curvature Strain Energy Academic Article
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Regulation of HCN Ion Channels by Non-canonical Cyclic Nucleotides Book
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Repellent Signaling by Slit Requires the Leucine-Rich Repeats Academic Article
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Requirement of Lysine Residues Outside of the Proposed Pentasaccharide Binding Region for High Affinity Heparin Binding and Activation of Human Antithrombin III Academic Article
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Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr Academic Article
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Role of Membrane Defects in the Regulation of the Activity of Protein Kinase C Academic Article
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Role of aromatic substituents on the antiproliferative effects of diphenyl ferrocenyl butene compounds Academic Article
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Role of peptide structure in lipid-peptide interactions: a fluorescence study of the binding of pentagastrin-related pentapeptides to phospholipid vesicles Academic Article
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Role of peptide structure in lipid-peptide interactions: high-sensitivity differential scanning calorimetry and electron spin resonance studies of the structural properties of dimyristoylphosphatidylcholine membranes interacting with pentagastrin-related pentapeptides Academic Article
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Role of the position of unsaturation on the phase behavior and intrinsic curvature of phosphatidylethanolamines Academic Article
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Selective suppression of rapid eye movement sleep (REMS) in cats by typical and atypical antidepressants. Academic Article
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Sendai virus N-terminal fusion peptide consists of two similar repeats, both of which contribute to membrane fusion Academic Article
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Sequence-function relationships provide new insight into the cleavage site selectivity of the 8-17 RNA-cleaving deoxyribozyme Academic Article
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Shortened cytoplasmic domain affects intracellular transport but not nuclear localization of a viral glycoprotein. Academic Article
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Signal Transduction within G-protein Coupled Receptors via an Ion Tunnel: A Hypothesis Academic Article
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Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor Academic Article
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Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling Academic Article
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Small-Molecule Modulators of Listeria monocytogenes Biofilm Development Academic Article
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Specificity of Membrane Binding of the Neuronal Protein NAP-22 Academic Article
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Strategies for development of novel antithrombotics: modulating thrombin's procoagulant and anticoagulant properties Academic Article
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Streptogramins, Oxazolidinones, and Other Inhibitors of Bacterial Protein Synthesis Academic Article
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Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria Academic Article
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Structural Model for Dihydropyridine Binding to L-type Calcium Channels Academic Article
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Structural Model for Phenylalkylamine Binding to L-type Calcium Channels Academic Article
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Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4 Academic Article
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Structural and Functional Properties of an Unusual Internal Fusion Peptide in a Nonenveloped Virus Membrane Fusion Protein Academic Article
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Structural and Kinetic Characterization of the LPS Biosynthetic Enzyme d-α,β-d-Heptose-1,7-bisphosphate Phosphatase (GmhB) from Escherichia coli, Academic Article
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Structural determinants of the interactions of catechins with Aβ oligomers and lipid membranes Academic Article
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Structural determinants responsible for the biological activity of (-)-emetine, (-)-cryptopleurine, and (-)-tylocrebrine: structure-activity relationship among related compounds. Academic Article
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Structural requirements for glucagon receptor binding and activation of adenylate cyclase in liver. Study of chemically modified forms of the hormone, including N alpha-trinitrophenyl glucagon, an antagonist. Academic Article
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Structural requirements for specific inhibition of microsomal aminopeptidase by mercaptoamines Academic Article
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Structural–Functional Studies of Burkholderia cenocepacia d-Glycero-β-d-manno-heptose 7-Phosphate Kinase (HldA) and Characterization of Inhibitors with Antibiotic Adjuvant and Antivirulence Properties Academic Article
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Structure Academic Article
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Structure Activity Studies on the Crinane Alkaloid Apoptosis-inducing Pharmacophore Academic Article
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Structure and Composition of the Fusion Pore Academic Article
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Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme Academic Article
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Structure and Mechanism of the Lincosamide Antibiotic Adenylyltransferase LinB Academic Article
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Structure and function of aspartate transcarbamoylase studied using chymotrypsin as a probe Academic Article
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Structure-Activity Studies on Mammalian Adenosine Kinase Academic Article
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Structure-Function Relationship in a Winter Flounder Antifreeze Polypeptide Academic Article
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Structure-Function Relationships in a Winter Flounder Antifreeze Polypeptide Academic Article
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Structure-activity studies on N -Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation Academic Article
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Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells Academic Article
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Structure-activity study and design of multidrug-resistant reversal compounds by a computer automated structure evaluation methodology. Academic Article
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Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance Academic Article
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Structures of shorthorn sculpin antifreeze polypeptides Academic Article
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Structure–Function Relationships of Human Milk Oligosaccharides on the Intestinal Epithelial Transcriptome in Caco‐2 Cells and a Murine Model of Necrotizing Enterocolitis Academic Article
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Structure–activity studies of echinomycin antibiotics against drug-resistant and biofilm-forming Staphylococcus aureus and Enterococcus faecalis Academic Article
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Structure–activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids Academic Article
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Structure–activity studies on seco-pancratistatin analogs: Potent inhibitors of human cytochrome P450 3A4 Academic Article
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Structure–function studies on Hsp47: pH-dependent inhibition of collagen fibril formation in vitro Academic Article
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Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore Academic Article
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Studies on chemically modified forms of the myelin basic protein: Requirements for encephalitogenicity Academic Article
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Synergistic effect of purine derivatives on the toxicity of pyrazofurin and 6-azauridine towards cultured mammalian cells Academic Article
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Synthesis and Dopamine Receptor Modulating Activity of 3-Substituted γ-Lactam Peptidomimetics of l-Prolyl-l-leucyl-glycinamide Academic Article
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Synthesis and Dopamine Receptor Modulating Activity of Substituted Bicyclic Thiazolidine Lactam Peptidomimetics of l-Prolyl-l-leucyl-glycinamide Academic Article
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Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation Academic Article
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Synthesis and Properties of Carborane-Functionalized Aliphatic Polyester Dendrimers Academic Article
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Synthesis and Screening of Mono- and Di-Aryl Technetium and Rhenium Metallocarboranes. A New Class of Probes for the Estrogen Receptor Academic Article
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Synthesis and Screening of a Library of Re/Tc-Based Amyloid Probes Derived from β-Breaker Peptides Academic Article
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Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide Academic Article
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Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases Academic Article
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Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives Academic Article
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Synthesis and biological characterisation of a series of iberiotoxin analogues Academic Article
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Synthesis and biological evaluation of analogs of Pro-Leu-Gly-NH2 modified at the leucyl residue Academic Article
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Synthesis and dopamine receptor modulating activity of lactam conformationally constrained analogs of Pro-Leu-Gly-NH2 Academic Article
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Synthesis and evaluation of new salicylaldehyde-2-picolinylhydrazone Schiff base compounds of Ru(II), Rh(III) and Ir(III) as in vitro antitumor, antibacterial and fluorescence imaging agents Academic Article
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Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (β-Lactones) Academic Article
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Synthesis and structure-activity relationships among glycosidic derivatives of 4'-demethylepipodophyllotoxin and epipodophyllotoxin, showing VM26- and VP16-213-like activities. Academic Article
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Synthesis of Boroxifen, A Nido-Carborane Analogue of Tamoxifen Academic Article
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Synthesis of Pro-Leu-Gly-NH2 analogs modified at the prolyl residue and evaluation of their effects on the receptor binding activity of the central dopamine receptor agonist, ADTN Academic Article
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Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies Academic Article
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Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii Academic Article
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Synthesis of α-methylstilbenes using an aqueous Wittig methodology and application toward the development of potent human aromatase inhibitors Academic Article
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The 5' flanking sequence negatively modulates the in vivo expression and in vitro transcription of a human tRNA gene Academic Article
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The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory
clpP
Gene as a Novel Antibiotic Resistance Factor Academic Article
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The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents Academic Article
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The Auto-Inhibitory Role of the EPAC Hinge Helix as Mapped by NMR Academic Article
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The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2 Academic Article
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The Large Cytoplasmic Domain Is Not Required for Concentration of N-CAM at Cell-Cell Contacts in Transfected Mouse Neuroblastoma Cells Academic Article
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The M358R variant of α 1 -proteinase inhibitor inhibits coagulation factor VIIa Academic Article
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The Pattern of Amino Acid Replacements in α/β-Barrels Academic Article
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The Polar Region Consecutive to the HIV Fusion Peptide Participates in Membrane Fusion Academic Article
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The Reduction of Hydroxypyruvate by Human Serum Academic Article
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The Solution Conformational Features of Two Highly Homologous Antigenic Peptides of Foot-and-mouth Disease Virus Serotype A, Variants A and USA, Correlate with their Serological Properties Academic Article
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The Structural Diversity of Deoxyribozymes Academic Article
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The Structural Integrity of Anion Binding Exosite I of Thrombin Is Required and Sufficient for Timely Cleavage and Activation of Factor V and Factor VIII Academic Article
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The Transferable Tail: Fusion of the N-Terminal Acidic Extension of Heparin Cofactor II to α1-Proteinase Inhibitor M358R Specifically Increases the Rate of Thrombin Inhibition Academic Article
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The antimicrobial peptide trichogin and its interaction with phospholipid membranes Academic Article
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The dependence of the lipolytic activity of Rhizopus arrhizus lipase on surfactant concentration in Aerosol-OT/isooctane reverse micelles and its relationship to enzyme structure Academic Article
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The effect of cholesterol on the interaction of glucagon with the gel state of dimyristoylphosphatidylcholine Academic Article
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The effect of free fatty acids on the thermotropic phase transition of dimyristoyl glycerophosphocholine Academic Article
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The effects of low molecular weight and standard heparin on calcium loss from fetal rat calvaria Academic Article
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The effects of membrane physical properties on the fusion of Sendai virus with human erythrocyte ghosts and liposomes. Analysis of kinetics and extent of fusion. Academic Article
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The essential role of the imidazole group of glucagon in its biological function Academic Article
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The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells Academic Article
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The p56 -interacting Protein p62 Stimulates Transcription via the SV40 Enhancer Academic Article
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The relevance of the structure of lysine bound to Sepharose for the affinity of rabbit plasminogen Academic Article
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The role of hydroxyproline in collagen folding: Conformational energy calculations on oligopeptides containing proline and hydroxyproline Academic Article
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The role of nonspecific hydrophobic interactions in the biological activity of N epsilon-acyl derivatives of glucagon. Studies of conformation, receptor binding, and adenylate cyclase activation. Academic Article
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Theoretical study of interaction of winter flounder antifreeze protein with ice Academic Article
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Thiopeptides: antibiotics with unique chemical structures and diverse biological activities Academic Article
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Thrombin Inhibition by Hirudin: How Hirudin Inhibits Thrombin Academic Article
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Thrombin structure and function Academic Article
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Total Synthesis and Activity of the Metallo-β-lactamase Inhibitor Aspergillomarasmine A Academic Article
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Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure-Activity Relationships Academic Article
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Towards a structure-function analysis of bovine lactoferricin and related tryptophan- and arginine-containing peptides Conference Paper
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Transformation of Pro-Leu-Gly-NH2 Peptidomimetic Positive Allosteric Modulators of the Dopamine D2 Receptor into Negative Modulators Academic Article
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Trichogin: a paradigm for lipopeptaibols Academic Article
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Virus replication inhibitory peptide inhibits the conversion of phospholipid bilayers to the hexagonal phase Academic Article
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[Conformation of 1,3-bis(p-chlorobenzylidene amino)guanidine (chimcoccide) and its interaction with calcium ions]. Academic Article
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[Distance between the ammonium groups of polymethylene bistrimethyl-ammonium compounds based on theoretical conformational analysis data]. Academic Article
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[Molecular physiology of adrenoreceptors]. Academic Article
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[Predisposition of the optimal conformations of adrenergic compounds to the formation of polydentate complexes with metal ions]. Academic Article
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[Simulation of DNA conformation possibilities by means of nonbonded interaction energy calculations of complementary dinucleoside phosphate complexes]. Academic Article
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[Use of theoretical conformational analysis for solving the problem of the relationship between structure and action of cholinergic blockaders (difasil and amizil)]. Academic Article
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d-penicillamine: Chemistry and clinical use in rheumatic disease Academic Article
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iso-Lactam and reduced amide analogues of the peptidomimetic dopamine receptor modulator 3(R)-[(2(S)-Pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide Academic Article
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von Willebrand Factor: Form for Function Academic Article