Structure-Activity Relationship

subject area of

.beta.-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22 Journal Articles
1,4-Dihydropyridine Scaffold in Medicinal Chemistry, The Story so Far And Perspectives (Part 1): Action in Ion Channels and GPCRs Journal Articles
2 Mechanisms of action of low molecular weight heparins and heparinoids Journal Articles
2-[125I]Iodomelatonin binding sites in the quail heart: Characteristics, distribution and modulation by guanine nucleotides and cations Journal Articles
3D organization and function of the cell: Golgi budding and vesicle biogenesis to docking at the porosome complex Journal Articles
4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction Journal Articles
A 2.13 Å Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region Journal Articles
A 23bp Insertion in the Endothelial Protein C Receptor (EPCR) Gene Impairs EPCR Function Journal Articles
A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using ^99mTc- and ¹⁷⁷Lu-Labeled Tetrazines Journal Articles
A Highly Dynamic Loop of the Pseudomonas aeruginosa PA14 Type IV Pilin Is Essential for Pilus Assembly Journal Articles
A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor Journal Articles
A New Strategy To Improve the Metabolic Stability of Lactone: Discovery of (20S,21S)-21-Fluorocamptothecins as Novel, Hydrolytically Stable Topoisomerase I Inhibitors Journal Articles
A Refined Model for the Somatostatin Pharmacophore: Conformational Analysis of Lanthionine−Sandostatin Analogs Journal Articles
A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome Journal Articles
A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection Journal Articles
A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase Journal Articles
A comprehensive study of genic variation in natural populations of Drosophila melanogaster. V. Structural–functional constraints on protein molecules and enzymes and the levels and patterns of variation among genes Journal Articles
A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both α- and β-ketone reduction during chain growth Journal Articles
A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function Journal Articles
A proposal: That the heterogeneity of glycoprotein N-glycans is a feature of their biosynthesis and may be of functional significance Journal Articles
A recurrent de novo HSPD1 variant is associated with hypomyelinating leukodystrophy Journal Articles
Acyclic model peptides with ionophoretic activity. Pr3+ transport by N-tBoc-Pro-Xxx-Ala-NHCH3. Journal Articles
Allosteric Modulation of the Dopamine D₂ Receptor by Pro-Leu-Gly-NH₂ Peptidomimetics Constrained in Either a Polyproline II Helix or a Type II β-Turn Conformation Journal Articles
Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity Journal Articles
Altering Heparin Cofactor II at VAL439 (P6) either Impairs Inhibition of Thrombin or Confers Elastase Resistance Journal Articles
Amino acid substitutions of the P2 residue of human antithrombin that either enhance or impair function Journal Articles
Aminorifamycins and Sporalactams Produced in Culture by a Micromonospora sp. Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics Journal Articles
An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria Journal Articles
Antagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues Journal Articles
Antibiotics as probes of biological complexity Journal Articles
Antibodies to Catecholamines Journal Articles
Antibodies to Indolealkylamines; Serotonin and Melatonin Journal Articles
Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311 Journal Articles
Antimitotic activity of structurally simplified biaryl analogs of the anticancer agents colchicine and combretastatin A4 Journal Articles
Antineoplastic Agents 491.¹ Synthetic Conversion of Aaptamine to Isoaaptamine, 9-Demethylaaptamine, and 4-Methylaaptamine Journal Articles
Antitussive, expectorant and anti-inflammatory alkaloids from Bulbus Fritillariae Cirrhosae. Journal Articles
Aortic smooth muscle and endothelial plasma membrane Ca²⁺ pump isoforms are inhibited differently by the extracellular inhibitor caloxin 1b1 Journal Articles
Architecture of the Neuronal Nicotinic Acetylcholine Receptor Ion Channel at the Binding Site of bis-Ammonium Blockers Journal Articles
Are the pharmacological effects of L-prolyl-L-leucylglycinamide (PLG) mediated through specific receptor mechanisms? Journal Articles
Arginine Methylation Regulates Telomere Length and Stability Journal Articles
Basis for Selectivity of Cationic Antimicrobial Peptides for Bacterial Versus Mammalian Membranes Journal Articles
Bicyclic thiazolidine lactam peptidomimetics of the dopamine receptor modulating peptide Pro-Leu-Gly-NH2 Journal Articles
Binding of secretory component to protein 511, a pIgA mouse protein lacking 36 amino acid residues of the Cα3 domain Journal Articles
Bioactive paper dipstick sensors for acetylcholinesterase inhibitors based on sol–gel/enzyme/gold nanoparticle composites Journal Articles
Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window” Journal Articles
Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor Journal Articles
Biological activity of metabolites of PGD2 on canine proximal colon Journal Articles
Biological effects of nitrofurans Journal Articles
Biosynthesis of Vitamin B₆. Incorporation of Terminally Labelled Glucose Journal Articles
Biosynthetic utilization of photoreactive fatty acids by rat liver microsomes Journal Articles
Bone recognition mechanism of porcine osteocalcin from crystal structure Journal Articles
Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes Journal Articles
Ca2+-dependent Antifreeze Proteins Journal Articles
Capping DNA with DNA Journal Articles
Carbapenems and Lipid Bilayers: Localization, Partitioning, and Energetics Journal Articles
Cephalosporin-induced hypoprothrombinemia: is the N-methylthiotetrazole side chain the culprit? Journal Articles
Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73 Journal Articles
Characterization and Biologic Activities of Recombinant Rat Soluble Interleukin-6 Receptor Journal Articles
Characterization of a Distinctive Motif of the Low Molecular Weight Neurotrophin Receptor that Modulates NGF‐mediated Neurite Growth Journal Articles
Chloramphenicol damages bacterial DNA Journal Articles
Chloride Channels of Glycine and GABA Receptors with Blockers: Monte Carlo Minimization and Structure-Activity Relationships Journal Articles
Circular dichroism of type 13 beta -turn in linear tripeptides containing L-proline and D-alanine. Journal Articles
Cold Stress Makes Escherichia coli Susceptible to Glycopeptide Antibiotics by Altering Outer Membrane Integrity Journal Articles
Comparative biochemistry of cytochrome c oxidase in animals Journal Articles
Comparison of Heparin- and Dermatan Sulfate-mediated Catalysis of Thrombin Inactivation by Heparin Cofactor II Journal Articles
Conformation of a synthetic hexapeptide substrate of collagen lysyl hydroxylase Journal Articles
Conformational Analysis of the Ca²⁺-Bound Opioid Peptides: Implications for Ligand-Receptor Interaction Journal Articles
Conformational implications of enzymatic proline hydroxylation in collagen. Journal Articles
Cooperativity of papain-substrate interaction energies in the S2 to S2' subsites Journal Articles
Cross-chimeric analysis of selectivity of secretin and VPAC(1) receptor activation. Journal Articles
Crystal Structure of a Ca2+-discharged Photoprotein Journal Articles
Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases Journal Articles
Cytochrome P450 3A4 Inhibitory Activity Studies within the Lycorine series of Alkaloids Journal Articles
Cytotoxicity and DNA damage to mammalian cells by nitrofurans Journal Articles
Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape Journal Articles
Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA Journal Articles
Design and Synthesis of Photoaffinity-Labeling Ligands of thel-Prolyl-l-leucylglycinamide Binding Site Involved in the Allosteric Modulation of the Dopamine Receptor Journal Articles
Design and synthesis of [ 125 I]Pyricoxib: A novel 125 I-labeled cyclooxygenase-2 (COX-2) inhibitors Journal Articles
Design, Synthesis, and Dopamine Receptor Modulating Activity of Spiro Bicyclic Peptidomimetics ofl-Prolyl-l-leucyl-glycinamide Journal Articles
Design, synthesis and biological activity of piperlongumine derivatives as selective anticancer agents Journal Articles
Development of a specific assay for cardiac glycoside-like compounds based on cross-resistance of human cell mutants Journal Articles
Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents Journal Articles
Dimensions of the ion channel in neuronal nicotinic acetylcholine receptor as estimated from analysis of conformation-activity relationships of open-channel blocking drugs Journal Articles
Dimerization of the P-glycoprotein in membranes Journal Articles
Dinucleotide Junction Cleavage Versatility of 8-17 Deoxyribozyme Journal Articles
Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein. Journal Articles
Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma Journal Articles
Discovery of a Novel Series of Tricyclic Oxadiazine 4a-Methyl Esters Based on Indoxacarb as Potential Sodium Channel Blocker/Modulator Insecticides Journal Articles
Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1) Journal Articles
Discovery of a novel class of aldol-derived 1,2,3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase) Journal Articles
Discovery of potent antiviral (HSV-1) quinazolinones and initial structure-activity relationship studies Journal Articles
Dopamine receptor modulation by Pro-Leu-Gly-NH2 analogs possessing cyclic amino acid residues at the C-terminal position Journal Articles
Dopamine receptor modulation by conformationally constrained analogs of Pro-Leu-Gly-NH2 Journal Articles
Down-regulation of haloperidol-induced striatal dopamine receptor supersensitivity by active analogues of L-prolyl-L-leucyl-glycinamide (PLG) Journal Articles
Drug evaluation: AP-23573--an mTOR inhibitor for the treatment of cancer. Journal Articles
Drug evaluation: E-5564. Journal Articles
EFFECTS OF TETRANDRINE AND CLOSELY RELATED BIS‐BENZYLISOQUINOLINE DERIVATIVES ON CYTOSOLIC Ca²⁺ IN HUMAN LEUKAEMIC HL‐60 CELLS: A STRUCTURE‐ACTIVITY RELATIONSHIP STUDY Journal Articles
Effects of heparin, its low molecular weight fractions and other glycosaminoglycans on thrombus growth Journal Articles
Effects of some isoprostanes on the human umbilical artery in vitro Journal Articles
Elastase-mediated fibrinogenolysis by chemoattractant-stimulated neutrophils occurs in the presence of physiologic concentrations of antiproteinases. Journal Articles
Electrostatic Control of Phospholipid Polymorphism Journal Articles
Enantioselective Synthesis of Planar Chiral Ferrocifens that Show Chiral Discrimination in Antiproliferative Activity on Breast Cancer Cells Journal Articles
Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase Journal Articles
Evaluation of peroxisome proliferator‐activated receptor agonists on interleukin‐5‐induced eosinophil differentiation Journal Articles
Evaluation of synthetic coumarins for antiausterity cytotoxicity against pancreatic cancers Journal Articles
Evidence for Allosteric Linkage between Exosites 1 and 2 of Thrombin Journal Articles
Excitatory and inhibitory actions of isoprostanes in human and canine airway smooth muscle. Journal Articles
Facile Construction of Structurally Diverse Thiazolidinedione-Derived Compounds via Divergent Stereoselective Cascade Organocatalysis and Their Biological Exploratory Studies Journal Articles
Factors Promoting Tamoxifen Resistance in Breast Cancer via Stimulating Breast Cancer Stem Cell Expansion Journal Articles
Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia Journal Articles
From Bench to Bedside Journal Articles
Functional Analysis of Disulfide Linkages Clustered within the Amino Terminus of Human Apolipoprotein B Journal Articles
Fundamentals of Endotoxin Structure and Function Journal Articles
General method for the determination of precursor configuration in biosynthetic precursor-product relations. Derivation of pipecolic acid from D-lysine, and of piperidine alkaloids from L-lysine Journal Articles
Genetic and biochemical studies with mutants of mammalian cells affected in microtubule-related proteins other than tubulin: mitochondrial localization of a microtubule-related protein Journal Articles
Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model Journal Articles
Genome duplication events have led to a diversification in the CPT I gene family in fish Journal Articles
Green tea catechins evoke a phasic contraction in rat aorta via H₂O₂‐mediated multiple‐signalling pathways Journal Articles
HPLC-purified 2-[125I]iodomelatonin labels multiple binding sites in hamster brain Journal Articles
Heparin-induced thrombocytopenia. Journal Articles
Histamine potentiation by hydroxylamines: structure-activity relations; inhibition of diamine oxidase Journal Articles
Homocysteine-dependent Alterations in Mitochondrial Gene Expression, Function and Structure Journal Articles
Homology Models of μ-Opioid Receptor with Organic and Inorganic Cations at Conserved Aspartates in the Second and Third Transmembrane Domains Journal Articles
Homology Requirements for Ligation and Strand Exchange by the FLP Recombinase Journal Articles
Host Defense Peptide LL-37, in Synergy with Inflammatory Mediator IL-1β, Augments Immune Responses by Multiple Pathways Journal Articles
Human cell mutants affected in the interaction of the 12β-OH group of cardiac glycosides with the digitalis receptor Journal Articles
INVIVO EFFECTS OF LOW-MOLECULAR-WEIGHT HEPARINS ON EXPERIMENTAL THROMBOSIS AND BLEEDING Journal Articles
Identification of 2-benzimidazolyl urea as a new antimitotic compound based on cross resistance studies with nocodazole resistant mutants of cho cells Journal Articles
Identification of Regions in HIV-1 Nef Required for Efficient Downregulation of Cell Surface CD4 Journal Articles
Identification of a GroES (CPN10)-related sequence motif in the GroEL (CPN60) chaperonins. Journal Articles
Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity Journal Articles
Identification of the Binding Site of Brucella VirB8 Interaction Inhibitors Journal Articles
Impacts of Structural Photomodification on the Toxicity of Environmental Contaminants: Anthracene Photooxidation Products Journal Articles
In vivo Effects of Low Molecular Weight Heparins on Experimental Thrombosis and Bleeding Journal Articles
Incorporation of cell-adhesion peptides into collagen scaffolds promotes corneal epithelial stratification Journal Articles
Increased sulphation improves the anticoagulant activities of heparan sulphate and dermatan sulphate Journal Articles
Indolealkylamines and prolactin secretion a structure-activity study in the central nervous system of the rat Journal Articles
Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition Journal Articles
Influence of Cleavage Site on Global Folding of an RNA‐Cleaving DNAzyme Journal Articles
Inhibition of adenosine kinase by phosphonate and bisphosphonate derivatives Journal Articles
Inhibition of leucine aminopeptidase by amino acid hydroxamates. Journal Articles
Insertion of a Structural Domain of Interleukin (IL)-1β Confers Agonist Activity to the IL-1 Receptor Antagonist Journal Articles
Interaction of the BK_Cachannel gating ring with dendrotoxins Journal Articles
Interactions of corneal epithelial cells and surfaces modified with cell adhesion peptide combinations Journal Articles
Interactions of drugs and toxins with permeant ions in potassium, sodium, and calcium channels. Journal Articles
Intermolecular crosslinking of fatty acyl chains in phospholipids: use of photoactivable carbene precursors. Journal Articles
Investigating serpin–enzyme complex formation and stability via single and multiple residue reactive centre loop substitutions in heparin cofactor II Journal Articles
Investigation of aryl halides as ketone bioisosteres: Refinement of potent and selective inhibitors of human cytochrome P450 19A1 (aromatase) Journal Articles
Ion occupancy of the channel pore is critical for triggering excitation-transcription (ET) coupling Journal Articles
Isolation and characterization of insertion mutants in E1A of adenovirus type 5 Journal Articles
KvAP-Based Model of the Pore Region of Shaker Potassium Channel Is Consistent with Cadmium- and Ligand-Binding Experiments Journal Articles
L-Leucinthiol — A potent inhibitor of leucine aminopeptidase Journal Articles
Lanthionine−Somatostatin Analogs: Synthesis, Characterization, Biological Activity, and Enzymatic Stability Studies Journal Articles
Ligand action on sodium, potassium, and calcium channels: role of permeant ions Journal Articles
Ligand interactions at the active site of aspartate transcarbamoylase from Escherichia coli Journal Articles
Liver fibrosis attributed to lipid lowering medications: two cases Journal Articles
Metal-Induced Isomerization Yields an Intracellular Chelator that Disrupts Bacterial Iron Homeostasis Journal Articles
Modularity of protein function: Chimeric interleukin 1.beta.s containing specific protease inhibitor loops retain function of both molecules Journal Articles
Molecular structural analysis of a novel and de‐novo mutation in the SERPINC1 gene associated with type 1 antithrombin deficiency Journal Articles
Multiple sites and synergism in the binding of inhibitors to microsomal aminopeptidase Journal Articles
Mutagenic reaction products of aqueous chlorination of catechol Journal Articles
Mutagenicity of nitrofuran derivatives: Review Journal Articles
Mutants of CHO cells resistant to the protein synthesis inhibitors, cryptopleurine and tylocrebrine: genetic and biochemical evidence for common site of action of emetine, cryptopleurine, tylocrebrine, and tubulosine Journal Articles
Mutants of HeLa cells resistant to ouabain and cassaine: Genetic evidence for the common site of action of cardiac glycosides and erythrophleum alkaloids Journal Articles
Mutational analysis of Salmonella translocated effector members SifA and SopD2 reveals domains implicated in translocation, subcellular localization and function Journal Articles
NMR Structures Reveal How Oxidation Inactivates Thrombomodulin Journal Articles
Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis Journal Articles
Non-sterol structural probes of the lanosterol 14α-demethylase from Saccharomyces cerevisiae Journal Articles
Nonenzymatic Breakdown of the Tetrahedral (α-Carboxyketal Phosphate) Intermediates of MurA and AroA, Two Carboxyvinyl Transferases. Protonation of Different Functional Groups Controls the Rate and Fate of Breakdown Journal Articles
One-pot, multicomponent synthesis of 2,3-disubstituted quinazolin-ones with potent and selective activity against Toxoplasma gondii Journal Articles
Ordered surface carbons distinguish antifreeze proteins and their ice-binding regions Journal Articles
Organometallic Antitumor Compounds: Ferrocifens as Precursors to Quinone Methides Journal Articles
Overlapping Binding Sites of Structurally Different Antiarrhythmics Flecainide and Propafenone in the Subunit Interface of Potassium Channel Kv2.1* Journal Articles
Palmitoyl‐dl‐Carnitine is a Multitarget Inhibitor of Pseudomonas aeruginosa Biofilm Development Journal Articles
Penicillin's catalytic mechanism revealed by inelastic neutrons and quantum chemical theory Journal Articles
Pharmacology of L-prolyl-L-leucyl-glycinamide (PLG): a review. Journal Articles
Phenylalkylamines in calcium channels: computational analysis of experimental structures Journal Articles
Phosphorus‐containing inhibitors of aspartate transcarbamoylase from Escherichia coli Journal Articles
Phosphorylated Derivatives That Activate or Inhibit Mammalian Adenosine Kinase Provide Insights into the Role of Pentavalent Ions in AK Catalysis Journal Articles
Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes Journal Articles
Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross-resistance studies with various microtubule inhibitors and podophyllotoxin analogues. Journal Articles
Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs Journal Articles
Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives Journal Articles
Preclinical differentiation of low molecular weight heparins. Journal Articles
Predicting the reactivity of ambidentate nucleophiles and electrophiles using a single, general-purpose, reactivity indicator Journal Articles
Preparation and Evaluation of Carborane Analogues of Tamoxifen Journal Articles
Preparation and characterization of alkylated poly(vinyl alcohol) hydrogels using alkyl halides Journal Articles
Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors Journal Articles
Probing the "active site" of diamine oxidase: structure-activity relations for histamine potentiation by O-alkylhydroxylamines on colonic epithelium. Journal Articles
Processing of the Papain Precursor Journal Articles
Protein adsorption to polyethylene glycol modified liposomes from fibrinogen solution and from plasma Journal Articles
Rapid Systematic Screening of Bispecific Antibody Surrogate Geometries for T-Cell Engagement Using DNA Nanotechnology. Journal Articles
Rationale Behind the Development of Low Molecular Weight Heparin Derivatives Journal Articles
Receptors and signaling pathway underlying relaxations to isoprostanes in canine and porcine airway smooth muscle Journal Articles
Recognition of Anionic Porphyrins by DNA Aptamers Journal Articles
Regulation of HCN Ion Channels by Non-canonical Cyclic Nucleotides Books
Repellent Signaling by Slit Requires the Leucine-Rich Repeats Journal Articles
Requirement of Lysine Residues Outside of the Proposed Pentasaccharide Binding Region for High Affinity Heparin Binding and Activation of Human Antithrombin III Journal Articles
Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr Journal Articles
Role of aromatic substituents on the antiproliferative effects of diphenyl ferrocenyl butene compounds Journal Articles
Selective suppression of rapid eye movement sleep (REMS) in cats by typical and atypical antidepressants. Journal Articles
Sequence-function relationships provide new insight into the cleavage site selectivity of the 8-17 RNA-cleaving deoxyribozyme Journal Articles
Signal Transduction within G-protein Coupled Receptors via an Ion Tunnel: A Hypothesis Journal Articles
Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor Journal Articles
Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling Journal Articles
Small-Molecule Modulators of Listeria monocytogenes Biofilm Development Journal Articles
Streptogramins, Oxazolidinones, and Other Inhibitors of Bacterial Protein Synthesis Journal Articles
Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria Journal Articles
Structural Model for Dihydropyridine Binding to L-type Calcium Channels Journal Articles
Structural Model for Phenylalkylamine Binding to L-type Calcium Channels Journal Articles
Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4 Journal Articles
Structural and Kinetic Characterization of the LPS Biosynthetic Enzyme d-α,β-d-Heptose-1,7-bisphosphate Phosphatase (GmhB) from Escherichia coli, Journal Articles
Structural determinants of the interactions of catechins with Aβ oligomers and lipid membranes Journal Articles
Structural determinants responsible for the biological activity of (-)-emetine, (-)-cryptopleurine, and (-)-tylocrebrine: structure-activity relationship among related compounds. Journal Articles
Structural requirements for specific inhibition of microsomal aminopeptidase by mercaptoamines Journal Articles
Structural–Functional Studies of Burkholderia cenocepacia d-Glycero-β-d-manno-heptose 7-Phosphate Kinase (HldA) and Characterization of Inhibitors with Antibiotic Adjuvant and Antivirulence Properties Journal Articles
Structure Journal Articles
Structure Activity Studies on the Crinane Alkaloid Apoptosis-inducing Pharmacophore Journal Articles
Structure and Composition of the Fusion Pore Journal Articles
Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme Journal Articles
Structure and Mechanism of the Lincosamide Antibiotic Adenylyltransferase LinB Journal Articles
Structure and function of aspartate transcarbamoylase studied using chymotrypsin as a probe Journal Articles
Structure-Activity Studies on Mammalian Adenosine Kinase Journal Articles
Structure-Function Relationship in a Winter Flounder Antifreeze Polypeptide Journal Articles
Structure-Function Relationships in a Winter Flounder Antifreeze Polypeptide Journal Articles
Structure-activity studies on N -Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation Journal Articles
Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells Journal Articles
Structure-activity-relationships of the Stability of Six Pentathiepins Towards Glutathione: Possible Correlations with Biological Activities. Journal Articles
Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance Journal Articles
Structures of shorthorn sculpin antifreeze polypeptides Journal Articles
Structure–Function Relationships of Human Milk Oligosaccharides on the Intestinal Epithelial Transcriptome in Caco‐2 Cells and a Murine Model of Necrotizing Enterocolitis Journal Articles
Structure–activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids Journal Articles
Structure–activity studies on seco-pancratistatin analogs: Potent inhibitors of human cytochrome P450 3A4 Journal Articles
Structure–function studies on Hsp47: pH-dependent inhibition of collagen fibril formation in vitro Journal Articles
Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore Journal Articles
Studies on the Mutagenicity of Mild Gasification Products of Coal and Their Subfractions by theSalmonella/Microsomal Assay Journal Articles
Synergistic effect of purine derivatives on the toxicity of pyrazofurin and 6‐azauridine towards cultured mammalian cells Journal Articles
Synthesis and Dopamine Receptor Modulating Activity of 3-Substituted γ-Lactam Peptidomimetics of l-Prolyl-l-leucyl-glycinamide Journal Articles
Synthesis and Dopamine Receptor Modulating Activity of Substituted Bicyclic Thiazolidine Lactam Peptidomimetics of l-Prolyl-l-leucyl-glycinamide Journal Articles
Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation Journal Articles
Synthesis and Preclinical Evaluation of [¹⁸F]SiFA-PSMA Inhibitors in a Prostate Cancer Model Journal Articles
Synthesis and Properties of Carborane-Functionalized Aliphatic Polyester Dendrimers Journal Articles
Synthesis and Screening of Mono- and Di-Aryl Technetium and Rhenium Metallocarboranes. A New Class of Probes for the Estrogen Receptor Journal Articles
Synthesis and Screening of a Library of Re/Tc-Based Amyloid Probes Derived from β-Breaker Peptides Journal Articles
Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide Journal Articles
Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases Journal Articles
Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives Journal Articles
Synthesis and biological characterisation of a series of iberiotoxin analogues Journal Articles
Synthesis and biological evaluation of analogs of Pro-Leu-Gly-NH2 modified at the leucyl residue Journal Articles
Synthesis and dopamine receptor modulating activity of lactam conformationally constrained analogs of Pro-Leu-Gly-NH2 Journal Articles
Synthesis and evaluation of new salicylaldehyde-2-picolinylhydrazone Schiff base compounds of Ru(II), Rh(III) and Ir(III) as in vitro antitumor, antibacterial and fluorescence imaging agents Journal Articles
Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (β-Lactones) Journal Articles
Synthesis and structure-activity relationships among glycosidic derivatives of 4'-demethylepipodophyllotoxin and epipodophyllotoxin, showing VM26- and VP16-213-like activities. Journal Articles
Synthesis of Boroxifen, A Nido-Carborane Analogue of Tamoxifen Journal Articles
Synthesis of Pro-Leu-Gly-NH2 analogs modified at the prolyl residue and evaluation of their effects on the receptor binding activity of the central dopamine receptor agonist, ADTN Journal Articles
Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies Journal Articles
Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii Journal Articles
Synthesis of α-methylstilbenes using an aqueous Wittig methodology and application toward the development of potent human aromatase inhibitors Journal Articles
The 5' flanking sequence negatively modulates the in vivo expression and in vitro transcription of a human tRNA gene Journal Articles
The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor Journal Articles
The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents Journal Articles
The Auto-Inhibitory Role of the EPAC Hinge Helix as Mapped by NMR Journal Articles
The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2 Journal Articles
The M358R variant of α 1 -proteinase inhibitor inhibits coagulation factor VIIa Journal Articles
The Pattern of Amino Acid Replacements in α/β-Barrels Journal Articles
The Reduction of Hydroxypyruvate by Human Serum Journal Articles
The Solution Conformational Features of Two Highly Homologous Antigenic Peptides of Foot‐and‐mouth Disease Virus Serotype A, Variants A and USA, Correlate with their Serological Properties Journal Articles
The Structural Diversity of Deoxyribozymes Journal Articles
The Structural Integrity of Anion Binding Exosite I of Thrombin Is Required and Sufficient for Timely Cleavage and Activation of Factor V and Factor VIII Journal Articles
The Transferable Tail: Fusion of the N-Terminal Acidic Extension of Heparin Cofactor II to α₁-Proteinase Inhibitor M358R Specifically Increases the Rate of Thrombin Inhibition Journal Articles
The dependence of the lipolytic activity of Rhizopus arrhizus lipase on surfactant concentration in Aerosol-OT/isooctane reverse micelles and its relationship to enzyme structure Journal Articles
The effects of low molecular weight and standard heparin on calcium loss from fetal rat calvaria Journal Articles
The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells Journal Articles
The influence of local DNA sequence and DNA repair background on the mutational specificity of 1-nitroso-8-nitropyrene in Escherichia coli: inferences for mutagenic mechanisms. Journal Articles
The p56 -interacting Protein p62 Stimulates Transcription via the SV40 Enhancer Journal Articles
The relevance of the structure of lysine bound to Sepharose for the affinity of rabbit plasminogen Journal Articles
The role of hydroxyproline in collagen folding: Conformational energy calculations on oligopeptides containing proline and hydroxyproline Journal Articles
Theoretical study of interaction of winter flounder antifreeze protein with ice Journal Articles
Thiopeptides: antibiotics with unique chemical structures and diverse biological activities Journal Articles
Thrombin Inhibition by Hirudin: How Hirudin Inhibits Thrombin Journal Articles
Thrombin structure and function Journal Articles
Total Synthesis and Activity of the Metallo‐β‐lactamase Inhibitor Aspergillomarasmine A Journal Articles
Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure–Activity Relationships Journal Articles
Transformation of Pro-Leu-Gly-NH₂ Peptidomimetic Positive Allosteric Modulators of the Dopamine D₂ Receptor into Negative Modulators Journal Articles
[Conformation of 1,3-bis(p-chlorobenzylidene amino)guanidine (chimcoccide) and its interaction with calcium ions]. Journal Articles
[Distance between the ammonium groups of polymethylene bistrimethyl-ammonium compounds based on theoretical conformational analysis data]. Journal Articles
[Molecular physiology of adrenoreceptors]. Journal Articles
[Predisposition of the optimal conformations of adrenergic compounds to the formation of polydentate complexes with metal ions]. Journal Articles
[Simulation of DNA conformation possibilities by means of nonbonded interaction energy calculations of complementary dinucleoside phosphate complexes]. Journal Articles
[Use of theoretical conformational analysis for solving the problem of the relationship between structure and action of cholinergic blockaders (difasil and amizil)]. Journal Articles
iso-Lactam and reduced amide analogues of the peptidomimetic dopamine receptor modulator 3(R)-[(2(S)-Pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide Journal Articles
von Willebrand Factor: Form for Function Journal Articles

Structure-Activity Relationship Concept

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