Journal article
Human cell mutants affected in the interaction of the 12β-OH group of cardiac glycosides with the digitalis receptor
Abstract
The cross-resistance patterns of two different types of mutants of HeLa cells selected for resistance to the digoxin analog SC4453 (SCR mutants) in which the Na+/K+-ATPase is affected [A. Chopra and R. S. Gupta, J. biol. Chem. 261, 2034 (1986)], and towards numerous cardiac glycosides (CGs) and genins, were examined. One type of SCR mutant (designated as group C) was highly resistant to all CGs and genins investigated. In contrast, the other …
Authors
Gupta RS; Chopra A
Journal
Biochemical Pharmacology, Vol. 36, No. 22, pp. 3829–3833
Publisher
Elsevier
Publication Date
November 1987
DOI
10.1016/0006-2952(87)90445-x
ISSN
0006-2952