Role of aromatic substituents on the antiproliferative effects of diphenyl ferrocenyl butene compounds Journal Articles uri icon

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  • We have been exploring the cytotoxic effects of conjugated phenylferrocene systems on breast cancer cells. Complexes with p-OH, p-NH(2), and p-NHC(O)CH(3) substitution show particularly high activity, with IC(50) values in the low or sub micromolar range for both the hormone-dependent MCF-7 and hormone-independent MDA-MB-231 breast cancer cell lines. We now present the synthesis, X-ray crystal structures and biochemical studies of analogous halogen or pseudo-halogen para-substituted compounds with R = Cl, (Z)-7a; Br, (Z)-7b; CF(3), (E)-7c; and CN, (E)-7d and (Z)-7d. Lacking hydrogen bonding groups, the compounds have low, but non-zero, relative binding affinity values for the oestrogen receptor alpha (RBA


  • Zekri, Ouardia
  • Hillard, Elizabeth A
  • Top, Siden
  • Vessières, Anne
  • Pigeon, Pascal
  • Plamont, Marie-Aude
  • Huché, Michel
  • Boutamine, Sultana
  • Mcglinchey, Michael James
  • Müller-Bunz, Helge
  • Jaouen, Gérard

publication date

  • 2009

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