Journal article
Structure and Mechanism of the Lincosamide Antibiotic Adenylyltransferase LinB
Abstract
Lincosamides make up an important class of antibiotics used against a wide range of pathogens, including methicillin-resistant Staphylococcus aureus. Predictably, lincosamide-resistant microorganisms have emerged with antibiotic modification as one of their major resistance strategies. Inactivating enzymes LinB/A catalyze adenylylation of the drug; however, little is known about their mechanistic and structural properties. We determined two …
Authors
Morar M; Bhullar K; Hughes DW; Junop M; Wright GD
Journal
Structure, Vol. 17, No. 12, pp. 1649–1659
Publisher
Elsevier
Publication Date
12 2009
DOI
10.1016/j.str.2009.10.013
ISSN
0969-2126