Journal article
Dimerization of the P-glycoprotein in membranes
Abstract
Plasma membranes from a CHO cell line, CHRC5, which exhibits multidrug resistance was studied using radiation inactivation analysis. The P-glycoprotein content of the membrane was determined by Western blots. Irradiation resulted in the loss of P-glycoprotein. The dependence of this loss on radiation dose corresponded to a target size of 250 kDa which is the molecular mass of a dimer of the P-glycoprotein. This is strong evidence to indicate …
Authors
Boscoboinik D; Debanne MT; Stafford AR; Jung CY; Gupta RS; Epand RM
Journal
Biochimica et Biophysica Acta, Vol. 1027, No. 3, pp. 225–228
Publisher
Elsevier
Publication Date
September 1990
DOI
10.1016/0005-2736(90)90311-b
ISSN
0006-3002