Dimerization of the P-glycoprotein in membranes Journal Articles uri icon

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  • Plasma membranes from a CHO cell line, CHRC5, which exhibits multidrug resistance was studied using radiation inactivation analysis. The P-glycoprotein content of the membrane was determined by Western blots. Irradiation resulted in the loss of P-glycoprotein. The dependence of this loss on radiation dose corresponded to a target size of 250 kDa which is the molecular mass of a dimer of the P-glycoprotein. This is strong evidence to indicate that the P-glycoprotein self associates in the membrane.


  • Boscoboinik, Daniel
  • Debanne, Maria Theresa
  • Stafford, Alan R
  • Jung, Chan Y
  • Gupta, Radhey Shyam
  • Epand, Richard M

publication date

  • September 1990