Journal article
Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation
Abstract
Inspired by nature: Angelmarin is an anticancer natural product with potent antiausterity activity, that is, selective cytotoxicity towards nutrient-deprived, resistant cancer cells. Through structure-activity relationship studies, three analogues were identified as lead compounds for the develpoment of molecular probes for the investigation of the mode of action and biological targets of the antiausterity compounds.
Authors
Magolan J; Adams NBP; Onozuka H; Hungerford NL; Esumi H; Coster MJ
Journal
ChemMedChem, Vol. 7, No. 5, pp. 766–770
Publisher
Wiley
Publication Date
May 2012
DOI
10.1002/cmdc.201100564
ISSN
1860-7179