Journal article
Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes
Abstract
Plazomicin is a next-generation, semisynthetic aminoglycoside antibiotic currently under development for the treatment of infections due to multidrug-resistant Enterobacteriaceae. The compound was designed by chemical modification of the natural product sisomicin to provide protection from common aminoglycoside modifying enzymes that chemically alter these drugs via N-acetylation, O-adenylylation, or O-phosphorylation. In this study, plazomicin …
Authors
Cox G; Ejim L; Stogios PJ; Koteva K; Bordeleau E; Evdokimova E; Sieron AO; Savchenko A; Serio AW; Krause KM
Journal
ACS Infectious Diseases, Vol. 4, No. 6, pp. 980–987
Publisher
American Chemical Society (ACS)
Publication Date
June 8, 2018
DOI
10.1021/acsinfecdis.8b00001
ISSN
2373-8227