Molecular physiology of adrenoreceptors.

The paper reviews some problems of theoretical investigation of the spatial of adrenergic drugs and their receptors, citing results recently obtained by the authors. It includes the chapters as follows: Introduction; Conformation - activity relationships of ligands; Theoretical conformational analysis; Noradrenaline; Classification and some models of adrenergic receptors; Problems of ligands productive conformation selection and the description of receptor topography; Principles of choice of ligands; Criteria for productive conformation selection; Productive conformations of beta 2-adrenergic agonists and beta 2-receptor topography; Productive conformations of alpha 1-adrenergic receptor ligands and alpha 1-receptor topography; Structure-activity relationships of some ligands in the light of adrenergic beta 2- and alpha 1-receptors topography; Possible role of calcium ion in the interaction of adrenergic agonists with receptors.