Journal article
EFFECTS OF TETRANDRINE AND CLOSELY RELATED BIS‐BENZYLISOQUINOLINE DERIVATIVES ON CYTOSOLIC Ca2+ IN HUMAN LEUKAEMIC HL‐60 CELLS: A STRUCTURE‐ACTIVITY RELATIONSHIP STUDY
Abstract
1. Previously it has been shown that tetrandrine (TET), a bis-benzylisoquinoline alkaloid, isolated from a Chinese herb Stephania tetrandra, can block non-voltage-operated Ca2+ entry activated by intracellular Ca2+ store depletion induced by thapsigargin (TSG) and can release intracellular Ca2+ in HL-60 cells. The present study attempted to identify the chemical group(s) of the TET molecule responsible for these dual effects. The effects of TET …
Authors
Leung Y; Berdik M; Kwan C; Loh T
Journal
Clinical and Experimental Pharmacology and Physiology, Vol. 23, No. 8, pp. 653–659
Publisher
Wiley
Publication Date
August 1996
DOI
10.1111/j.1440-1681.1996.tb01752.x
ISSN
0305-1870