Journal article
Thiopeptides: antibiotics with unique chemical structures and diverse biological activities
Abstract
Thiopeptides are a class of natural product antibiotics with diverse structures and functions. Their complex structures and biosynthesis have intrigued researchers since their discovery in 1948, but not a single thiopeptide has been approved for human use. This is mainly due to their poor solubility, challenging synthesis, and low bioavailability. This review summarizes the current research on the biosynthesis and biological activity of …
Authors
Chan DCK; Burrows LL
Journal
The Journal of Antibiotics, Vol. 74, No. 3, pp. 161–175
Publisher
Springer Nature
Publication Date
March 2021
DOI
10.1038/s41429-020-00387-x
ISSN
0021-8820