Journal article
Enantioselective Synthesis of Planar Chiral Ferrocifens that Show Chiral Discrimination in Antiproliferative Activity on Breast Cancer Cells
Abstract
The design and first enantioselective synthesis of a series of chiral ferrocifens and ferrociphenols was realised by enantioselective palladium-catalysed intramolecular direct C-H bond activation followed by McMurry coupling. Biological evaluation revealed moderate anticancer activities on breast cancer cells and evidence of chiral discrimination between enantiomers. Treatment of the novel ferrocifens with Ag2 O revealed that these systems are …
Authors
Cunningham L; Wang Y; Nottingham C; Pagsulingan J; Jaouen G; McGlinchey MJ; Guiry PJ
Journal
ChemBioChem, Vol. 21, No. 20, pp. 2974–2981
Publisher
Wiley
Publication Date
October 15, 2020
DOI
10.1002/cbic.202000311
ISSN
1439-4227