Cephalosporin-induced hypoprothrombinemia: is the N-methylthiotetrazole side chain the culprit? Journal Articles uri icon

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  • The reported high incidence of vitamin-K-reversible hypoprothrombinemia associated with the new beta-lactamase-stable cephalosporins prompted us to evaluate the effect on hemostasis of three cephalosporins (cefamandole, ceftriaxone, and ceftazidime) in 30 patients with serious infections. Cefamandole and ceftriaxone, both containing a sulfhydryl group, induced a significant and similar prolongation of prothrombin time and decrease in factor VII activity. Ceftazidime, in contrast, had no effect on these two parameters.


  • Agnelli, G
  • Del Favero, A
  • Parise, P
  • Guerciolini, R
  • Pasticci, B
  • Nenci, GG
  • Ofosu, Frederick A

publication date

  • June 1986