Aminorifamycins and Sporalactams Produced in Culture by a Micromonospora sp. Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics Academic Article uri icon

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abstract

  • The new ansa macrolide antibiotics 1 to 4 have been isolated from cultures of a Micromonospora sp. obtained from a marine sediment. Rifamycins 1 and 2 are the first natural ansa macrolides to have a 3-amino substituent. Sporalactams A (3) and B (4) are comprised of a heterocylic core 5 and a 14-membered ansa bridge that are both unprecedented. Sporalactam B (4) shows selective and potent inhibition of Mycobacterium tuberculosis.

authors

  • Williams, David E
  • Dalisay, Doralyn S
  • Chen, Jessie
  • Polishchuck, Elena A
  • Patrick, Brian O
  • Narula, Gagandeep
  • Ko, Mary
  • Av-Gay, Yossef
  • Li, Haoxin
  • Magarvey, Nathan
  • Andersen, Raymond J

publication date

  • February 17, 2017