Journal article
Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity
Abstract
Candida species are among the most prevalent causes of systemic fungal infections, which account for ∼1.5 million annual fatalities. Here, we build on a compound screen that identified the molecule N-pyrimidinyl-β-thiophenylacrylamide (NP-BTA), which strongly inhibits Candida albicans growth. NP-BTA was hypothesized to target C. albicans glutaminyl-tRNA synthetase, Gln4. Here, we confirmed through in vitro amino-acylation assays NP-BTA is a …
Authors
Puumala E; Sychantha D; Lach E; Reeves S; Nabeela S; Fogal M; Nigam A; Johnson JW; Aspuru-Guzik A; Shapiro RS
Journal
Cell Chemical Biology, Vol. 31, No. 4, pp. 760–775.e17
Publisher
Elsevier
Publication Date
4 2024
DOI
10.1016/j.chembiol.2024.01.010
ISSN
2451-9456