Journal article
Interaction of the BKCa channel gating ring with dendrotoxins
Abstract
Two classes of small homologous basic proteins, mamba snake dendrotoxins (DTX) and bovine pancreatic trypsin inhibitor (BPTI), block the large conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1) by production of discrete subconductance events when added to the intracellular side of the membrane. This toxin-channel interaction is unlikely to be pharmacologically relevant to the action of mamba venom, but as a fortuitous ligand-protein …
Authors
Takacs Z; Imredy JP; Bingham J-P; Zhorov BS; Moczydlowski EG
Journal
Channels, Vol. 8, No. 5, pp. 421–432
Publisher
Taylor & Francis
Publication Date
September 3, 2014
DOI
10.4161/19336950.2014.949186
ISSN
1933-6950